Ligand 4-methyl-5-(2-hydroxyethyl)-thiazole

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Basic Ligand Information

Molecular Structure
Picture of 4-methyl-5-(2-hydroxyethyl)-thiazole (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H9NOS
4-methyl-5-(2-hydroxyethyl)-thiazole
BKAWJIRCKVUVED-UHFFFAOYSA-N
Synonyms:
4-methyl-5-(2'-hydroxyethyl)-thiazole, 4-methyl-5-(2-hydroxyethyl)thiazole, 4-methyl-5-(beta-hydroxyethyl)-thiazole, 5-(2-hydroxyethyl)-4-methylthiazole

Show all pahtways known for Show all BRENDA pathways known for 4-methyl-5-(2-hydroxyethyl)-thiazole

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
thiamine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (65 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Product in Enzyme-catalyzed Reactions (33 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
reactivation at 10 mM
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Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.1 mM, 12.3% inhibition

3D Structure of Enzyme-Ligand-Complex (PDB) (26 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
2.28
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pH 7.5, 37°C

KM Value (2 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for 4-methyl-5-(2-hydroxyethyl)-thiazole

ChEBI
PubChem
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PubChem