Ligand Pantoate

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Basic Ligand Information

Molecular Structure
Picture of Pantoate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H12O4
Pantoate
OTOIIPJYVQJATP-UHFFFAOYSA-N
Synonyms:
2,4-dihydroxy-3,3-dimethylbutanoate, 2,4-dihydroxy-3,3-dimethylbutanoic acid, 2,4-dihydroxy-3,3-dimethylbutyric acid, 3,3-dimethyl-2,4-dihydroxybutanoate, pantoic acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
ATP + pantoate = ADP + 4-phosphopantoate
-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
ketopantoate + NADPH = pantoate + NADP+

Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE

Product in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
-
show the reaction diagram
pantothenate + H2O = 2,4-dihydroxy-3,3-dimethylbutyric acid + beta-alanine
-

Inhibitor in Enzyme-catalyzed Reactions (3 results)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE
noncompetitive versus ketopantoate and NADPH
0.05 mM or above
-
substrate inhibition
-

3D Structure of Enzyme-Ligand-Complex (PDB) (11 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

COMMENTARY
EC NUMBER
LITERATURE
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
42°C
1.56
-
pH 7.5, 42°C
2.82
-

KM Value (3 results)

COMMENTARY
EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
LITERATURE
+/-0.04
0.26
-
42°C
1.2
-
pH 7.5, 42°C
2.92
-

Ki Value (1 result)

COMMENTARY
EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
LITERATURE
pH 7.5, 42°C
9.75
-

References & Links

Links to other databases for Pantoate

ChEBI
PubChem
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PubChem