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Ligand Pantoate Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C6 H1 2 O4
Pantoate
OTOIIPJYVQJATP-UHFFFAOYSA-N
2,4-dihydroxy-3,3-dimethylbutanoate, 2,4-dihydroxy-3,3-dimethylbutanoic acid, 2,4-dihydroxy-3,3-dimethylbutyric acid, 3,3-dimethyl-2,4-dihydroxybutanoate, pantoic acid
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + pantoate = ADP + 4-phosphopantoate
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ketopantoate + NADPH = pantoate + NADP+
Substrate in Enzyme-catalyzed Reactions (4 results)
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ATP + pantoate = ADP + 4-phosphopantoate
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CTP + pantoate = CDP + 4-phosphopantoate
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GTP + pantoate = GDP + 4-phosphopantoate
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UTP + pantoate = UDP + 4-phosphopantoate
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Product in Enzyme-catalyzed Reactions (10 results)
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ketopantoate + NADPH = pantoate + NADP+
ketopantoic acid + NADH = pantoic acid + NAD+
ketopantoic acid + NADPH = pantoic acid + NADP+
2-oxo-3,3-dimethyl-4-hydroxybutanoate + reduced benzyl viologen = 3,3-dimethyl-2,4-dihydroxybutanoate + oxidized benzyl viologen
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2-oxo-3,3-dimethyl-4-hydroxybutanoate + reduced methyl viologen = 3,3-dimethyl-2,4-dihydroxybutanoate + oxidized methyl viologen
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alpha-hydroxy-beta,beta-dimethyl-gamma-butyrolactone + H2O = 2,4-dihydroxy-3,3-dimethylbutanoate
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pantoyl lactone + H2O = 2,4-dihydroxy-3,3-dimethylbutanoic acid
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DL-pantoyl lactone + H2O = pantoic acid
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DL-pantoyllactone + H2O = pantoic acid
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pantothenate + H2O = 2,4-dihydroxy-3,3-dimethylbutyric acid + beta-alanine
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Inhibitor in Enzyme-catalyzed Reactions (3 results)
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noncompetitive versus ketopantoate and NADPH
3D Structure of Enzyme-Ligand-Complex (PDB) (11 results)
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (2 results)
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KM Value (3 results)
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Ki Value (1 result)
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References & Links Literature References (9)
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Separation and preliminary studies on 2-ketopantoyl lactone and 2-ketopantoic acid reductases of yeast
1972
King, H.L.; Wilken, D.R.
J. Biol. Chem.
247
4096-4098
Ketopantoic acid and ketopantoyl lactone reductases. Stereospecificity of transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate
1975
Wilken, D.R.; King, H.L.; Dyar, R.E.
J. Biol. Chem.
250
2311-2314
ApbA, the ketopantoate reductase enzyme of Salmonella typhimurium is required for the synthesis of thiamine via the alternative pyrimidine biosynthetic pathway
1998
Frodyma, M.E.; Downs, D.
J. Biol. Chem.
273
5572-5576
Kinetic and mechanistic analysis of the E. coli panE-encoded ketopantoate reductase
2000
Zheng, R.; Blanchard, J.S.
Biochemistry
39
3708-3717
Crystal structure of Escherichia coli ketopantoate reductase at 1.7 A resolution and insight into the enzyme mechanism
2001
Matak-Vinkovic, D.; Vinkovic, M.; Saldanha, S.A.; Ashurst, J.L.; von Delft, F.; Inoue, T.; Miguel, R.N.; Smith, A.G.; Blundell, T.L.; Abell, C.
Biochemistry
40
14493-14500
Ketopantoate hydroxymethyltransferase. II. Physical, catalytic, and regulatory properties
1976
Powers, S.G.; Snell, E.E.
J. Biol. Chem.
251
3786-3793
Purification and properties of ketopantoate hydroxymethyltransferase
1979
Powers, S.G.; Snell, E.E.
Methods Enzymol.
62
204-209
Pantoate kinase and phosphopantothenate synthetase, two novel enzymes necessary for CoA biosynthesis in the archaea
2009
Yokooji, Y.; Tomita, H.; Atomi, H.; Imanaka, T.
J. Biol. Chem.
284
28137-28145
Biochemical characterization of pantoate kinase, a novel enzyme necessary for coenzyme A biosynthesis in the Archaea
2012
Tomita, H.; Yokooji, Y.; Ishibashi, T.; Imanaka, T.; Atomi, H.
J. Bacteriol.
194
5434-5443
Links to other databases for Pantoate
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