Ligand leukotriene B4

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Basic Ligand Information

Molecular Structure
Picture of leukotriene B4 (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C20H32O4
leukotriene B4
VNYSSYRCGWBHLG-GEWAPNICSA-N
Synonyms:
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyeicosa-6,8,10,14-tetraenoate, (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate, 5(S),12R-dihydroxy-6,10-trans-8,14-ciseicosatetraenoic acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2 = 20-hydroxyleukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
-
leukotriene B4 + NADPH = ?
show the reaction diagram
-
UDP-glucuronate + leukotriene B4 = UDP + leukotriene B4 beta-D-glucuronoside
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitively inhibits leukotriene E4 omega-oxidation
-
substrate prostaglandin A1
-

Enzyme Kinetic Parameters

KM Value (16 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.01
-
recombinant enzyme

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.08
-
-
0.043
-
substrate prostaglandin A1

References & Links

Links to other databases for leukotriene B4

ChEBI
PubChem
ChEBI
PubChem