Ligand diacetyl-lysyl-tRNALys
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Basic Ligand Information
Molecular Structure
C38H53N13O24P3R
diacetyl-lysyl-tRNALys
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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diacetyl-lysyl-tRNALys + H2O = diacetyl-lysine + tRNALys
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Substrate in Enzyme-catalyzed Reactions (2 results)
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diacetyl-lysyl-tRNALys + H2O = diacetyl-lysine + tRNALys
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diacetyl-lysyl-tRNALys = diacetyl-Lys + tRNALys
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (14 results)
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0.002
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pH 7.5, 50°C, mutant enzyme D86A/K18A
0.002
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pH 7.5, 50°C, mutant enzyme K18A
0.0025
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pH 7.5, 50°C, mutant enzyme D86A
0.02
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pH 7.5, 50°C, mutant enzyme T90A
0.06
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pH 7.5, 50°C, mutant enzyme Q22A
0.06
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pH 7.5, 50°C, mutant enzyme T98A
0.07
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pH 7.5, 50°C, mutant enzyme K56A
0.1
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pH 7.5, 50°C, mutant enzyme H25A
0.27
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pH 7.5, 50°C, mutant enzyme Q54A
0.86
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dephosphorylated substrate, pH 7.5, 50°C, recombinant enzyme
1.8
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pH 7.5, 50°C, recombinant enzyme
1.8
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pH 7.5, 50°C, wild-type enzyme
2.2
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pH 7.5, 50°C, mutant enzyme K118A
KM Value (14 results)
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0.0000028
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dephosphorylated substrate, pH 7.5, 50°C, recombinant enzyme
0.000011
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pH 7.5, 50°C, recombinant enzyme
0.9
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pH 7.5, 50°C, mutant enzyme T98A
1.6
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pH 7.5, 50°C, mutant enzyme Q22A
2.9
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pH 7.5, 50°C, mutant enzyme Q54A
3.2
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pH 7.5, 50°C, mutant enzyme K56A
4.4
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pH 7.5, 50°C, mutant enzyme H25A
5.3
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pH 7.5, 50°C, mutant enzyme K18A
5.4
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pH 7.5, 50°C, mutant enzyme D86A
6.7
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pH 7.5, 50°C, mutant enzyme D86A/K18A
7.2
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pH 7.5, 50°C, mutant enzyme T90A
9.1
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pH 7.5, 50°C, wild-type enzyme
12.8
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pH 7.5, 50°C, mutant enzyme K118A
References & Links
Literature References (4)
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Peptidyl-tRNA hydrolase from Sulfolobus solfataricus
2003
Fromant, M.; Ferri-Fioni, M.L.; Plateau, P.; Blanquet, S.
Nucleic Acids Res.
31
3227-3235
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Crystal structure at 1.8 A resolution and identification of active site residues of Sulfolobus solfataricus peptidyl-tRNA hydrolase
2005
Fromant, M.; Scvhmitt, E.; Mechulam, Y.; Lazennec, C.; Plateau, P.; Blanquet, S.
Biochemistry
44
4292-4301
Characterization of peptidyl-tRNA hydrolase encoded by open reading frame Rv1014c of Mycobacterium tuberculosis H37Rv
2007
Bal, N.C.; Agrawal, H.; Meher, A.K.; Arora, A.
Biol. Chem.
388
467-479
NMR-based substrate analog docking to Escherichia coli peptidyl-tRNA hydrolase
2011
Giorgi, L.; Plateau, P.; O'Mahony, G.; Aubard, C.; Fromant, M.; Thureau, A.; Grotli, M.; Blanquet, S.; Bontems, F.
J. Mol. Biol.
412
619-633
Links to other databases for diacetyl-lysyl-tRNALys
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