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Ligand GDP-4-amino-4,6-dideoxy-alpha-D-mannose

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for GDP-4-amino-4,6-dideoxy-alpha-D-mannose

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Natural Substrate (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.2.14

10-formyltetrahydrofolate + GDP-alpha-D-perosamine = tetrahydrofolate + GDP-N-formyl-alpha-D-perosamine

760585, 762368

-

2.3.1.227

acetyl-CoA + GDP-4-amino-4,6-dideoxy-alpha-D-mannose = CoA + GDP-4-acetamido-4,6-dideoxy-alpha-D-mannose

722259

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In Vivo Product in Enzyme-catalyzed Reactions (3 results)

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Show Natural Product (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.6.1.102

GDP-4-dehydro-6-deoxy-alpha-D-mannose + L-glutamate = GDP-4-amino-4,6-dideoxy-alpha-D-mannose + 2-oxoglutarate

0

-

2.6.1.102

GDP-4-dehydro-6-deoxy-D-mannose + L-glutamate = GDP-alpha-D-perosamine + 2-oxoglutarate

0

-

2.6.1.102

GDP-4-dehydro-6-deoxy-D-mannose + L-glutamate = GDP-D-perosamine + 2-oxoglutarate

0

-

2.6.1.102

3 entries

Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.2.14

10-formyltetrahydrofolate + GDP-alpha-D-perosamine = tetrahydrofolate + GDP-N-formyl-alpha-D-perosamine

760585, 762368

-

2.3.1.227

acetyl-CoA + GDP-4-amino-4,6-dideoxy-alpha-D-mannose = CoA + GDP-4-acetamido-4,6-dideoxy-alpha-D-mannose

722259

-

4.2.1.168

GDP-D-perosamine + L-glutamate = GDP-4-dehydro-3,6-dideoxymannose + 2-oxoglutarate + ammonia

738573

-

Product in Enzyme-catalyzed Reactions (3 results)

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Show Product (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.6.1.102

GDP-4-dehydro-6-deoxy-alpha-D-mannose + L-glutamate = GDP-4-amino-4,6-dideoxy-alpha-D-mannose + 2-oxoglutarate

0

-

2.6.1.102

GDP-4-dehydro-6-deoxy-D-mannose + L-glutamate = GDP-alpha-D-perosamine + 2-oxoglutarate

0

-

2.6.1.102

GDP-4-dehydro-6-deoxy-D-mannose + L-glutamate = GDP-D-perosamine + 2-oxoglutarate

0

-

2.6.1.102

3 entries

Inhibitor in Enzyme-catalyzed Reactions (1 result)

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Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.1.2.14

substrate inhibition by GDP-alpha-D-perosamine is evident above 0.25 mM

760585

-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (1 entry)

EC NUMBER

ENZYME 3D STRUCTURE

4.2.1.47

5vyu, 3D-view

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.1.2.14

0.54

-

mutant enzyme D78A/F142A, at pH 8.0, temperature not specified in the publication

760585

K_M Value (2 results)

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Show KM Value (2 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.1.2.14

0.46

-

mutant enzyme D78A/F142A, at pH 8.0, temperature not specified in the publication

760585

2.3.1.227

0.32

-

pH 8.0, 37°C

722259

References & Links

Literature References (4)

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Show Reference (4 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

722259

18201574

Identification of the GDP-N-acetyl-d-perosamine producing enzymes from Escherichia coli O157:H7

2008

Albermann, C.; Beuttler, H.

FEBS Lett.

582

479-484

738573

18045869

GDP-4-keto-6-deoxy-D-mannose 3-dehydratase, accommodating a sugar substrate in the active site

2008

Cook, P.; Holden, H.

J. Biol. Chem.

283

4295-4303

760585

28636341

Biochemical Characterization of WbkC, an N-Formyltransferase from Brucella melitensis

2017

Riegert, A.S.; Chantigian, D.P.; Thoden, J.B.; Tipton, P.A.; Holden, H.M.

Biochemistry

56

3657-3668

762368

11081580

Genetic organisation of the lipopolysaccharide O-antigen biosynthesis region of Brucella melitensis 16M (wbk)

2000

Godfroid, F.; Cloeckaert, A.; Taminiau, B.; Danese, I.; Tibor, A.; De Bolle, X.; Mertens, P.; Letesson, J.

Res. Microbiol.

151

655-668

Links to other databases for GDP-4-amino-4,6-dideoxy-alpha-D-mannose

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Show Links (1 entry)

ChEBI

PubChem