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inhibition of isozyme A and isozyme B, mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-triphosphate
-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
-
hypericin-mediated inhibition of glutamate release appears to involve the suppression of mitogen-activated protein kinase pathway
-
inhibitor of autotaxin beta; new inhibitor of autotaxin beta
-
inhibitor of autotaxin beta; new inhibitor of autotaxin beta; new inhibitor of autotaxin beta
-
inhibits DNA relaxation activity, potent antagonist of cleavage complex stabilization by chemotherapeutics etoposide and amsacrine
-
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0.049
-
isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4)
0.198
-
isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4)
0.00017
-
IP3K-A, maximal inhibition 100%
0.00017
-
IP3K-C, maximal inhibition 100%
0.0016
-
tested on murine autotaxin alpha
0.0025
-
tested on human autotaxin gamma
0.0026
-
tested on murine autotaxin gamma
0.0028
-
tested on murine autotaxin beta
0.0029
-
tested on human autotaxin beta
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Catalytic inhibition of human DNA topoisomerase IIalpha by hypericin, a naphthodianthrone from St. John's wort (Hypericum perforatum)
2001
Peebles, K.A.; Baker, R.K.; Kurz, E.U.; Schneider, B.J.; Kroll, D.J.
Biochem. Pharmacol.
62
1059-1070
Antiproliferative plant and synthetic polyphenolics are specific inhibitors of vertebrate inositol-1,4,5-trisphosphate 3-kinases and inositol polyphosphate multikinase
2005
Mayr, G.W.; Windhorst, S.; Hillemeier, K.
J. Biol. Chem.
280
13229-13240
Characterization of the interaction of hypericin with protein kinase C in U-87 MG human glioma cells
2006
Kocanova, S.; Hornakova, T.; Hritz, J.; Jancura, D.; Chorvat, D.; Mateasik, A.; Ulicny, J.; Refregiers, M.; Maurizot, J.C.; Miskovsky, P.
Photochem. Photobiol.
82
720-728
Murine and human autotaxin alpha, beta, gamma isoforms: Gene organization, tissue distribution and biochemical characterization
2008
Giganti, A.; Rodriguez, M.; Fould, B.; Moulharat, N.; Coge, F.; Chomarat, P.; Galizzi, J.P.; Valet, P.; Saulnier-Blache, J.S.; Boutin, J.A.; Ferry, G.
J. Biol. Chem.
283
7776-7789
-
Antiproliferative plant and synthetic polyphenolics are specific inhibitors of vertebrate inositol-1,4,5-trisphosphate 3-kinases and inositol polyphosphate multikinase. [Erratum to document cited in CA143:003106]
2007
Mayr, G.W.; Windhorst, S.; Hillemeier, K.
J. Biol. Chem.
282
35424
Hypericin, the active component of St. Johns wort, inhibits glutamate release in the rat cerebrocortical synaptosomes via a mitogen-activated protein kinase-dependent pathway
2010
Chang, Y.; Wang, S.J.
Eur. J. Pharmacol.
634
53-61
Hypericins and thioredoxin reductase: Biochemical and docking studies disclose the molecular basis for effective inhibition by naphthodianthrones
2011
Sorrentino, F.; Karioti, A.; Gratteri, P.; Rigobello, M.P.; Scutari, G.; Messori, L.; Bindoli, A.; Chioccioli, M.; Gabbiani, C.; Bergonzi, M.C.; Bilia, A.R.
Bioorg. Med. Chem.
19
631-641
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