Ligand hypericin

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Basic Ligand Information

Molecular Structure
Picture of hypericin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C30H16O8
hypericin
YDOIFHVUBCIUHF-UHFFFAOYSA-N
Pathway Source
Pathways

Roles as Enzyme Ligand

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competes with 12-O-tetradecanoylphorbol 13-acetate for binding to the regulatory domain of PKC, localization of PKC isozymes alpha, delta, and gamma, high affinty binding and interaction witht he C1B domain of PKC, molecular modeling
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Inhibitor in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
hypericin-mediated inhibition of glutamate release appears to involve the suppression of mitogen-activated protein kinase pathway
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inhibits DNA relaxation activity, potent antagonist of cleavage complex stabilization by chemotherapeutics etoposide and amsacrine
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Enzyme Kinetic Parameters

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

IC50 Value (11 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE

References & Links

Links to other databases for hypericin

ChEBI
PubChem
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PubChem