Ligand cephalosporin G

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Basic Ligand Information

Molecular Structure
Picture of cephalosporin G (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C16H16N2O4S
cephalosporin G
CIPQGGYPCPIDBB-UHFFFAOYSA-N

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
cephalosporin G + 2-oxoglutarate + O2 = deacetylcephalosporin G + succinate + CO2
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Inhibitor in Enzyme-catalyzed Reactions (1 result)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE
79% inhibition; 79% inhibition at 1 mM
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (6 results)

COMMENTARY
EC NUMBER
LITERATURE
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
pH 7.5, 25°C, recombinant mutant T90A/P72L/A311V
0.122
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pH 7.5, 25°C, recombinant mutant T90A/P72L/A311V/A40V/M229I/T273A
0.326
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pH 7.5, 25°C, recombinant mutant T90A/P72L/A311V/A40V/M229I/T273A/V171L/R182W/F267L
pH 7.5, 25°C, recombinant mutant T90A/P72L/A311V/A40V/M229I/T273A/V171L/R182W/F267L/G108D
1.899
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pH 7.5, 25°C, recombinant wild-type enzyme
0.055
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KM Value (6 results)

COMMENTARY
EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
LITERATURE
pH 7.5, 25°C, recombinant mutant T90A/P72L/A311V
2.58
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pH 7.5, 25°C, recombinant mutant T90A/P72L/A311V/A40V/M229I/T273A
4.64
-
pH 7.5, 25°C, recombinant mutant T90A/P72L/A311V/A40V/M229I/T273A/V171L/R182W/F267L
pH 7.5, 25°C, recombinant mutant T90A/P72L/A311V/A40V/M229I/T273A/V171L/R182W/F267L/G108D
4.41
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pH 7.5, 25°C, recombinant wild-type enzyme
2.58
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References & Links

Links to other databases for cephalosporin G

ChEBI
PubChem
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PubChem