Ligand hesperidin

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Basic Ligand Information

Molecular Structure
Picture of hesperidin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C28H34O15
hesperidin
QUQPHWDTPGMPEX-QJBIFVCTSA-N
Synonyms:
hesperetin 7-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside]
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
UDP-L-rhamnose + hesperetin 7-O-beta-D-glucoside = UDP + hesperetin 7-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside]
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (20 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
starch + hesperidin = glycosyl hesperidin
show the reaction diagram
-
hesperidin + H2O = ?
show the reaction diagram
-
hesperidin + H2O = hesperetin + rutinose
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
UDP-L-rhamnose + hesperetin 7-O-beta-D-glucoside = UDP + hesperetin 7-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside]
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibitory effect on tyrosinase diphenolase, from citrus peel crude extracts
-
the enzyme activity is reduced by about 87% in the presence of hesperidin
-
slight inhibition
-
inhibits the efflux of the P-gp substrate rhodamine 123 in a concentration-dependent manner. Good candidates for the development of novel P-gp/MDR1 reversal agents which may enhance the accumulation and efficacy of chemotherapy agents
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (4 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
32.4
-
pH 5.0, 60°C
68.4
-
pH 5.5, 95°C

KM Value (10 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.6
-
pH 5.5, 95°C

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
9.16
-
-

IC50 Value (6 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
16.08
-
-
0.02042
-
pH 7.0 and 37°C
0.1103
-
at pH 7.4 and 37°C
0.0688
-
at pH 7.4 and 37°C

References & Links

Links to other databases for hesperidin

ChEBI
PubChem
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PubChem