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BRENDA support

Ligand phenylmercury acetate

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Basic Ligand Information

Molecular Structure
Picture of phenylmercury acetate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C8H9HgO2
phenylmercury acetate
XEBWQGVWTUSTLN-UHFFFAOYSA-M
Synonyms:
acetyloxy(phenyl)mercury, Mercuriphenylacetate, phenyl-mercuric acetate, Phenylmercuriacetate, phenyl mercuri acetate, phenylmercuric acetate, phenyl mercuric acetate, Phenyl mercury acetate


Show all pahtways known for Show all BRENDA pathways known for phenylmercury acetate

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (55 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
70% loss of activity after 24 h
-
Cu,Zn-SOD
-
mutant enzyme: no effect, wild type enzyme: inhibition
-
0.1 mM, 85% inhibition
-
73% inhibition at 0.5 mM
-
stabilizes enzyme in one of two possible conformations
-
0.1 mM, 96% inhibition
-
1 mM, 80% inhibition
-
1 mM, 20% residual activity
-
0.01 mM, no resiudal activity
-
95% inhibition at 0.025 mM
-
phenyl mercuric acetate
-
80% inhibition at 1 mM, 10 mM dithiothreitol protects
-
1 mM, 98% inhibition
-
1 mM, 98% inhibition
-
0.05 mM, complete inhibition
-
0.1 mM, 2% remaining activity
-
0.1 mM, 80% inhibition, 1 mM, complete inhibition, activity is restored by addition of 10 mM beta-mercaptoethanol
-
0.0005 mM, 4.3% of maximal activity
-
strong inhibition
-
reversible by 0.02-10 mM 2-mercaptoethanol, and by 10 mM Cys
-
enzyme activity increases until 40% of SH-groups are titrated, complete inhibition when all SH-groups are titrated
-

Enzyme Kinetic Parameters

KM Value (2 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.001
0.002
depending on enzyme solubilization
0.0007
-
-

References & Links

Links to other databases for phenylmercury acetate

ChEBI
PubChem
ChEBI
PubChem