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Ligand 5-L-glutamyl-Gly-Gly

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.17.3

gamma-Glu-Gly-Gly + ascorbate + O2 = gamma-Glu-Gly-NH2 + glyoxylate + dehydroascorbate + H2O

657649

-

2.3.2.2

5-L-glutamyglycylglycine + acceptor = glycylglycine + 5-L-glutamyl-acceptor

487943

-

6.3.1.8

gamma-Glu-Gly-Gly + spermidine + ATP = N1-(gamma-Glu-Gly-Gly)-spermidine + ADP + phosphate

966

-

Product in Enzyme-catalyzed Reactions (41 results)

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Show Product (41 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.2.2

5-L-glutamyl 4-nitroanilide + Gly-Gly = 4-nitroaniline + 5-L-glutamyl-Gly-Gly

0

-

2.3.2.2

5-L-glutamyl-4-nitroanilide + Gly-Gly = 4-nitroaniline + 5-L-glutamyl-Gly-Gly

0

-

2.3.2.2

5-L-glutamyl-L-His + Gly-Gly = L-His + 5-L-glutamyl-Gly-Gly

0

-

2.3.2.2

5-L-glutamyl-L-Met + Gly-Gly = L-Met + 5-L-glutamyl-Gly-Gly

0

-

2.3.2.2

5-L-glutamyl-L-Phe + Gly-Gly = L-Phe + 5-L-glutamyl-Gly-Gly

0

-

2.3.2.2

5-L-glutamyl-L-Trp + Gly-Gly = L-Trp + 5-L-glutamyl-Gly-Gly

0

-

2.3.2.2

5-L-glutamyl-L-Tyr + Gly-Gly = L-Tyr + 5-L-glutamyl-Gly-Gly

0

-

2.3.2.2

5-L-glutamyl-L-Val + Gly-Gly = L-Val + 5-L-glutamyl-Gly-Gly

0

-

2.3.2.2

gamma-Glu-Cys + Gly-Gly = Cys + 5-L-glutamyl-Gly-Gly

0

-

2.3.2.2

glutathione + Gly-Gly = L-cysteinylglycine + 5-L-glutamyl-Gly-Gly

0

-

2.3.2.2

L-Gln + Gly-Gly = NH3 + 5-L-glutamyl-Gly-Gly

0

-

2.3.2.2

5-L-glutamyl-4-nitroanilide + glycyl-glycine = 4-nitroaniline + 5-L-glutamyl-glycyl-glycine

0

-

2.3.2.2

L-gamma-glutamyl-4-nitroanilide + glycylglycine = 4-nitroaniline + 5-L-glutamyl-glycyl-glycine

0

-

2.3.2.2

5-L-glutamyl 3-carboxy-4-nitroanilide + glycylglycine = 5-L-glutamyl-glycylglycine + 3-carboxy-4-nitroaniline

0

-

2.3.2.2

5-L-glutamyl-(3-carboxyl)-4-nitroanilide + glycylglycine = 3-carboxyl-4-nitroaniline + 5-L-glutamyl-glycylglycine

0

-

2.3.2.2

5-L-glutamyl-2-naphthylamide + glycylglycine = 5-L-glutamyl-glycylglycine + 2-naphthylamine

0

-

2.3.2.2

5-L-glutamyl-3-carboxy-4-nitroanilide + glycylglycine = 5-L-glutamyl-glycylglycine + 3-carboxy-4-nitroaniline

0, 487933, 487934

-

2.3.2.2

5-L-glutamyl-4-methoxy-2-naphthylamide + glycylglycine = 5-L-glutamyl-glycylglycine + 4-methoxy-2-naphthylamine

0

-

2.3.2.2

5-L-glutamyl-4-nitroanilide + glycylglycine = 4-nitroaniline + 5-L-glutamyl-glycylglycine

0

-

2.3.2.2

5-L-glutamyl-4-nitroanilide + glycylglycine = 5-L-glutamyl-glycylglycine + 4-nitroaniline

0

-

2.3.2.2

5-L-glutamyl-7-amido-4-methylcoumarin + glycylglycine = 7-amino-4-methylcoumarin + 5-L-glutamyl-glycylglycine

0

-

2.3.2.2

5-L-glutamyl-L-leucine + glycylglycine = L-Leu + 5-L-glutamyl-glycylglycine

0

-

2.3.2.2

gamma-L-glutamyl-L-cysteinyl-glycine + glycylglycine = L-cysteinyl-glycine + 5-L-glutamyl-glycylglycine

0

-

2.3.2.2

glutamyl-(3-carboxyl)-4-nitroanilide + glycylglycine = 3-carboxyl-4-nitroaniline + 5-L-glutamyl-glycylglycine

0

-

2.3.2.2

glutathione disulfide + glycylglycine = L-Cys-Gly + 5-L-glutamyl-glycylglycine

0

-

2.3.2.2

GSH + glycylglycine = L-Cys-Gly + 5-L-glutamyl-glycylglycine

0

-

2.3.2.2

GSSG + glycylglycine = L-Cys-Gly + 5-L-glutamyl-glycylglycine

0

-

2.3.2.2

L-gamma-glutamyl-4-nitroanilide + glycylglycine = 4-nitroaniline + 5-L-glutamyl-glycylglycine

0

-

2.3.2.2

L-glutamine + glycylglycine = NH3 + 5-L-glutamyl-glycylglycine

0

-

2.3.2.2

leukotriene C4 + glycylglycine = leukotriene D4 + 5-L-glutamyl-glycylglycine

0

-

2.3.2.2

5-L-glutamyl 3-carboxy-4-nitronailide + glycylglycine = 5-amino-2-nitrobenzoic acid + 5-L-glutamylglycylglycine

0, 487934

-

2.3.2.2

5-L-glutamyl-4-nitroanilide + glycylglycine = 4-nitroaniline + 5-L-glutamylglycylglycine

487931, 0, 487922, 487935, 487937, 487949, 487956, 487961, 487963, 487934, 487924, 487972, 487966, 487932, 487923

-

2.3.2.2

(gamma-L-glutamyl)-4-nitroanilide + glycylglycine = 4-nitroaniline + gamma-glutamylglycylglycine

0

-

2.3.2.2

gamma-L-glutamyl-4-nitroanilide + Gly-Gly = 4-nitroaniline + gamma-L-glutamyl-Gly-Gly

0

-

2.3.2.2

S-nitroso-glutathione + glycyl-glycine = S-nitroso-cysteinylglycine + gamma-L-glutamyl-glycyl-glycine

0

-

3.4.19.14

glutathione sulfonic acid + H2O + glycylglycine = ? + gamma-glutamyl-glycylglycine

0

-

3.4.19.14

oxidized glutathione + H2O + glycylglycine = ? + gamma-glutamyl-glycylglycine

0

-

3.4.19.14

reduced glutathione + H2O + glycylglycine = ? + gamma-glutamyl-glycylglycine

0

-

3.4.19.14

S-(4-nitro-benzyl)glutathione + H2O + glycylglycine = ? + gamma-glutamyl-glycylglycine

0

-

3.4.19.14

S-methylglutathione + H2O + glycylglycine = ? + gamma-glutamyl-glycylglycine

0

-

2.3.2.2

35 entries

3.4.19.14

5 entries

6.3.2.3

ATP + L-gamma-Glu-Gly + Gly = ADP + phosphate + L-gamma-Glu-Gly-Gly

0

-

Enzyme Kinetic Parameters

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.14.17.3

2.1

-

pH 6.0, 37°C

657649

References & Links

Literature References (18)

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Show Reference (18 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

966

9041518

Characterization of the peptide substrate specificity of glutathionylspermidine synthetase from Crithidia fasciculata

1997

De Craecker, S.; Verbruggen, C.; Rajan, P.; Smith, K.; Haemers, A.; Fairlamb, A.H.

Mol. Biochem. Parasitol.

84

25-32

487922

36916

Identification, partial purification and biochemical characterization of gamma-glutamyltranspeptidase present as a membrane component in skimmed milk and milk fat-globule membranes, and in mammary-tumour virus from the milk of infected mice

1979

Franþois, C.; Calberg-Bacq, C.M.; Gosselin, L.; Kozma, S.; Osterrieth, P.M.

Biochim. Biophys. Acta

567

106-115

487923

32176

Purification and enzymatic properties of gamma-glutamyltransferase from bovine colostrum

1978

Yasumoto, K.; Iwami, K.; Fushiki, T.; Mitsuda, H.

J. Biochem.

84

1227-1236

487924

6135696

Purification and properties of bovine liver gamma-glutamyltransferase

1983

Furukawa, M.; Higashi, T.; Tateishi, N.; Ochi, K.; Sakamoto, Y.

J. Biochem.

93

839-846

487931

2868390

gamma-Glutamyl transpeptidase from kidney

1985

Tate, S.S.; Meister, A.

Methods Enzymol.

113

400-419

487932

-

gamma-Glutamyltransferase. (gamma-Glutamyl)-peptide:amino acid gamma-glutamyltransferase, EC 2.3.2.2. 1. General

1983

Shaw, L.M.

Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )

3

349-352

487933

-

gamma-Glutamyltransferase. (gamma-Glutamyl)-peptide:amino acid gamma-glutamyltransferase, EC 2.3.2.2. 2. Routine method

1983

Wahlefeld, A.W.; Bergmeyer, H.U.

Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )

3

352-356

487934

-

gamma-Glutamyltransferase. (gamma-Glutamyl)-peptide:amino acid gamma-glutamyltransferase, EC 2.3.2.2. 3. IFCC reference method (provisional)

1983

Shaw, L.M.; Stromme, J.H.

Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )

3

357-364

487935

6112969

gamma-Glutamyl transpeptidase from WI-38 fibroblasts: purification and active site modification studies

1981

Takahashi, S.; Zukin, R.S.; Steinman, H.M.

Arch. Biochem. Biophys.

207

87-95

487937

4442

Studies of human kidney gamma-glutamyl transpeptidase. Purification and structural, kinetic and immunological properties

1976

Miller, S.P.; Awasthi, Y.C.; Srivastava, S.K.

J. Biol. Chem.

251

2271-2278

487943

1371053

Purification and properties of gamma-glutamyltranspeptidase from Bacillus subtilis (natto)

1991

Ogawa, Y.; Hosoyama, H.; Hamano, M.; Motai, H.

Agric. Biol. Chem.

55

2971-2977

487949

35101

Isolation of anthglutin, an inhibitor of gamma-glutamyl transpeptidase from Penicillum oxalicum

1979

Minato, S.

Arch. Biochem. Biophys.

192

235-240

487956

8095866

Characterization of g-glutamyltranspeptidase from human hepatocellular carcinoma, compared with enzymes from normal liver and cirrhotic liver

1993

Ohta, H.; Sawabu, N.; Kawakami, H.; Watanabe, H.; Ozaki, K.; Toya, D.; Hattori, N.

Clin. Chim. Acta

214

83-92

487961

7816801

Expression of an active glycosylated human gamma-glutamyl transpeptidase mutant that lacks a membrane anchor domain

1995

Ikeda, Y.; Fujii, J.; Taniguchi, N.; Meister, A.

Proc. Natl. Acad. Sci. USA

92

126-130

487963

8827453

Effects of substitutions of the conserved histidine residues in human gamma-glutamyl transpeptidase

1996

Ikeda, Y.; Fujii, J.; Taniguchi, N.

J. Biochem.

119

1166-1170

487966

9882013

gamma-Glutamyl transpeptidase-dependent mutagenicity and cytotoxicity of gamma-glutamyl derivatives: a model for biochemical targeting of chemotherapeutic agents

1998

Keren, R.; Stark, A.A.

Environ. Mol. Mutagen.

32

377-386

487972

11891265

gamma-Glutamyl transpeptidase in transgenic tobacco plants. Cellular localization, processing, and biochemical properties

2002

Storozhenko, S.; Belles-Boix, E.; Babiychuk, E.; Herouart, D.; Davey, M.W.; Slooten, L.; Van Montagu, M.; Inze, D.; Kushnir, S.

Plant Physiol.

128

1109-1119

657649

12646261

Glutathione, S-substituted glutathiones, and leukotriene C4 as substrates for peptidylglycine alpha-amidating monooxygenase

2003

Miller, L.A.; Baumgart, L.E.; Chew, G.H.; deLong, M.A.; Galloway, L.C.; Jung, K.W.; Merkler, K.A.; Nagle, A.S.; Poore, D.D.; Yoon, C.H.; Merkler, D.J.

Arch. Biochem. Biophys.

412

3-12

Links to other databases for 5-L-glutamyl-Gly-Gly

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ChEBI

PubChem

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