Ligand L-4-hydroxythreonine

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Basic Ligand Information

Molecular Structure
Picture of L-4-hydroxythreonine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H9NO4
L-4-hydroxythreonine
JBNUARFQOCGDRK-GBXIJSLDSA-N
Synonyms:
4-hydroxy-L-threonine, 4-hydroxyl-L-threonine, L-threo-3-hydroxyhomoserine
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE
-
show the reaction diagram
glycine + glycolaldehyde = L-4-hydroxythreonine
-

Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
ATP + 4-hydroxy-L-threonine = ADP + 4-phospho-L-threonine
-
show the reaction diagram
ATP + 4-hydroxy-L-threonine = ADP + 4-phospho-L-threonine
-
show the reaction diagram
L-4-hydroxythreonine = glycine + glycolaldehyde
-

Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
-
show the reaction diagram
L-threonine + glycolaldehyde = acetaldehyde + 4-hydroxyl-L-threonine
-
-
show the reaction diagram
glycine + glycolaldehyde = L-4-hydroxythreonine
-

Inhibitor in Enzyme-catalyzed Reactions (2 results)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE
Ki: 0.006 mM
-
marked inhibition at 5 mM, abolished by 60 mM Mg2+
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (4 results)

COMMENTARY
EC NUMBER
LITERATURE
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
pH 8.0, 25°C

KM Value (4 results)

COMMENTARY
EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
LITERATURE
pH 8.0, 25°C

Ki Value (1 result)

COMMENTARY
EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
LITERATURE
-
0.006
-

References & Links

Links to other databases for L-4-hydroxythreonine

ChEBI
PubChem
-
PubChem