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Ligand Normetanephrine

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (4 results)

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Show Substrate (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.3.38

normetanephrine + O2 = ?

10665

-

2.1.1.28

normetanephrine + S-adenosyl-L-methionine = metanephrine + S-adenosyl-L-homocysteine

639430, 639431, 639439

-

2.3.1.5

acetyl-CoA + normetanephrine = CoA + N-acetylnormetanephrine

487628

-

2.8.2.1

3'-phosphoadenylylsulfate + normetanephrine = adenosine 3',5'-bisphosphate + ?

645680

-

Product in Enzyme-catalyzed Reactions (3 results)

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Show Product (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.336

2 S-adenosyl-L-methionine + (-)-norepinephrine = 2 S-adenosyl-L-homocysteine + 4-O-methylnorepinephrine + 3-O-methylnorepinephrine

0

-

2.1.1.6

norepinephrine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + normetanephrine

441540, 0

-

2.1.1.6

S-adenosyl-L-methionine + norepinephrine = S-adenosyl-L-homocysteine + normetanephrine

0

-

2.1.1.6

2 entries

Inhibitor in Enzyme-catalyzed Reactions (1 result)

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Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.6.1.5

-

640109

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

1.1.3.38

0.7

-

-

10665

K_M Value (3 results)

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Show KM Value (3 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.1.3.38

1.4

-

-

10665

2.1.1.28

0.05

-

-

639430

2.1.1.28

0.366

-

-

639439

2.1.1.28

2 entries

References & Links

Literature References (8)

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Show Reference (8 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

10665

8529652

Substrate specificity of flavin-dependent vanillyl-alcohol oxidase from Penicillium simplicissimum. Evidence for the production of 4-hydroxycinnamyl alcohols from 4-allylphenols

1995

Fraaije, M.W.; Veeger, C.; van Berkel, W.J.H.

Eur. J. Biochem.

234

271-277

441540

10516661

Catechol-O-methyltransferase activity in CHO cells expressing norepinephrine transporter

1999

Percy, E.; Kaye, D.M.; Lambert, G.W.; Gruskin, S.; Esler, M.D.; Du, X.J.

Br. J. Pharmacol.

128

774-780

487628

3625455

Multiple forms of arylalkylamine N-acetyltransferases in the rat pineal gland: purification of one molecular form

1987

Namboodiri, M.A.A.; Brownstein, M.J.; Weller, J.L.; Voisin, P.; Klein, D.C.

J. Pineal Res.

4

235-246

639430

13863458

Purification and properties of phenylethanolamine-N-methyltransferase

1962

Axelrod, J.

J. Biol. Chem.

237

1657-1660

639431

5412063

Purification and properties of bovine phenylethanolamine N-methyltransferase

1970

Connett, R.J.; Kirshner, N.

J. Biol. Chem.

245

329-334

639439

3298988

Norepinephrine N-methyltransferase from rabbit adrenal glands

1987

Fuller, R.W.

Methods Enzymol.

142

655-660

640109

14171223

Studies on the specificity of tyrosine-alpha-ketoglutarate transaminase

1964

Jacoby, G.A.; La Du, B.N.

J. Biol. Chem.

239

419-424

645680

11181495

Enzymatic characterization and interspecies difference of phenol sulfotransferases, ST1A forms

2001

Honma, W.; Kamiyama, Y.; Yoshinari, K.; Sasano, H.; Shimada, M.; Nagata, K.; Yamazoe, Y.

Drug Metab. Dispos.

29

274-281

Links to other databases for Normetanephrine

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Show Links (1 entry)

ChEBI

PubChem