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Ligand gentamicin X2

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.B120

S-adenosyl-L-methionine + gentamicin X2 = S-adenosyl-L-homocysteine + G418

757066

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Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Substrate (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.B120

S-adenosyl-L-methionine + gentamicin X2 = S-adenosyl-L-homocysteine + G418

757060, 757066

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Enzyme Kinetic Parameters

References & Links

Literature References (2)

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Show Reference (2 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

757060

23679096

GenK-catalyzed C-6' methylation in the biosynthesis of gentamicin isolation and characterization of a cobalamin-dependent radical SAM enzyme

2013

Kim, H.J.; McCarthy, R.M.; Ogasawara, Y.; Liu, Y.; Mansoorabadi, S.O.; LeVieux, J.; Liu, H.

J. Am. Chem. Soc.

135

8093-8096

757066

29091410

Reaction catalyzed by GenK, a cobalamin-dependent radical S-adenosyl-L-methionine methyltransferase in the biosynthetic pathway of gentamicin, proceeds with retention of configuration

2017

Kim, H.J.; Liu, Y.N.; McCarty, R.M.; Liu, H.W.

J. Am. Chem. Soc.

139

16084-16087

Links to other databases for gentamicin X2

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Show Links (1 entry)

ChEBI

PubChem

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