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Ligand gentamicin X2 Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C1 9 H3 8 N4 O1 0
gentamicin X2
HFLKNINDVFJPQT-ZFAMMYHGSA-N
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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S-adenosyl-L-methionine + gentamicin X2 = S-adenosyl-L-homocysteine + G418
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Substrate in Enzyme-catalyzed Reactions (1 result)
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S-adenosyl-L-methionine + gentamicin X2 = S-adenosyl-L-homocysteine + G418
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Enzyme Kinetic Parameters
References & Links Literature References (2)
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GenK-catalyzed C-6' methylation in the biosynthesis of gentamicin isolation and characterization of a cobalamin-dependent radical SAM enzyme
2013
Kim, H.J.; McCarthy, R.M.; Ogasawara, Y.; Liu, Y.; Mansoorabadi, S.O.; LeVieux, J.; Liu, H.
J. Am. Chem. Soc.
135
8093-8096
Reaction catalyzed by GenK, a cobalamin-dependent radical S-adenosyl-L-methionine methyltransferase in the biosynthetic pathway of gentamicin, proceeds with retention of configuration
2017
Kim, H.J.; Liu, Y.N.; McCarty, R.M.; Liu, H.W.
J. Am. Chem. Soc.
139
16084-16087
Links to other databases for gentamicin X2