Ligand chondroitin sulfate

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of chondroitin sulfate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C42H65N3O37S
chondroitin sulfate
TZSJZZCJWLPPDV-TWXILVSKSA-N
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
chondroitin sulfate + H2O = ?
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
UDP-D-glucuronate + chondroitin sulfate = ?
show the reaction diagram
-
3'-phosphoadenylyl sulfate + chondroitin sulfate = ?
show the reaction diagram
-
chondroitin sulfate + H2O = chondroitin + sulfate
show the reaction diagram
-
chondroitin sulfate + H2O = desulfated chondroitin sulfate + sulfate
show the reaction diagram
-
chondroitin sulfate + H2O = ?
show the reaction diagram
-
chondroitin sulfate = ?
show the reaction diagram
-
chondroitin sulfate = unsaturated sulfated chondroitin disaccharide
show the reaction diagram
-

Enzyme Cofactor/Cosubstrate (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
anticoagulant cofactor for APC
-

Activator in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
increases kininogen cleavage at above 1 mg/ml
-
activates hK6 in a concentration-dependent manner
-
non-essential activator in assays using low-molecular-mass substrates, 4fold stimulation of activity at 0.2 mM
-

Inhibitor in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
plasmalogen-specific PLA2
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
-999
-
after 14 h at pH 5.0 (fibrillar film formation) 20% activity (100% activity at pH 7.0, 0 h, with hyaluronic acid)

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.48
-
apparent KM, substrate calculated as disaccharide

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.000869
-
-

References & Links

Links to other databases for chondroitin sulfate

ChEBI
PubChem
-
PubChem