Ligand chloroacetaldehyde

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Basic Ligand Information

Molecular Structure
Picture of chloroacetaldehyde (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C2H3ClO
chloroacetaldehyde
QSKPIOLLBIHNAC-UHFFFAOYSA-N
Synonyms:
2-Chloroacetaldehyde, 2-chloroethanal, chloroethanal, Monochloroacetaldehyde

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
chloroacetaldehyde + NAD+ + H2O = chloroacetate + NADH + H+
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
chloroacetaldehyde + NADP+ + H2O = chloroacetate + NADPH + H+
show the reaction diagram
-
chloroacetaldehyde + NAD+ + H2O = chloroacetate + NADH + H+
show the reaction diagram
-
chloroacetaldehyde + NAD+ + H2O = chloroacetate + NADH + H+
show the reaction diagram
-
chloroacetaldehyde + H2O + O2 = chloroacetic acid + H2O2
show the reaction diagram
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L-threonine + chloroacetaldehyde = acetaldehyde + 4-chloro-L-threonine
show the reaction diagram
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D-ribulose 5-phosphate + chloroacetaldehyde = ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
86% residual activity at 1 mM chloroacetaldehyde at pH 9.5
-
0.25 mM, time-dependent inactivation
-
the enzyme is rapidly and irreversibly inactivated and loses 84.9% of its enzymatic activity in the presence of 200 mM chloroacetaldehyde
-
inactivates
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (5 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (13 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.043
-
-
0.0036
-
pH 7.5, 25°C

References & Links

Links to other databases for chloroacetaldehyde

ChEBI
PubChem
ChEBI
PubChem