Ligand 3-hydroxy-3-methylglutarate

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of 3-hydroxy-3-methylglutarate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H10O5
3-hydroxy-3-methylglutarate
NPOAOTPXWNWTSH-UHFFFAOYSA-N
Synonyms:
(S)-3-hydroxy-3-methylglutarate, 3-hydroxy-3-methyl glutarate, 3-methyl-3-hydroxyglutaric acid, Beta-hydroxy-beta-methylglutarate, Hydroxymethylglutarate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
succinyl-CoA + 3-hydroxy-3-methylglutarate = succinate + 3-hydroxy-3-methylglutaryl-CoA
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
hydroxymethylglutaryl-CoA + H2O = hydroxymethylglutarate + CoA
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Product in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
hydroxymethylglutaryl-CoA + H2O = hydroxymethylglutarate + CoA
show the reaction diagram
-
-
(S)-3-hydroxy-3-methylglutaryl-CoA + H2O = CoA + 3-hydroxy-3-methylglutarate
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

3D Structure of Enzyme-Ligand-Complex (PDB) (12 results)

Enzyme Kinetic Parameters

KM Value (7 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
4.5
-
standard conditions, inhibition by substrate analog

References & Links

Links to other databases for 3-hydroxy-3-methylglutarate

ChEBI
PubChem
-
PubChem