Ligand (+)-catechin

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Basic Ligand Information

Molecular Structure
Picture of (+)-catechin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C15H14O6
(+)-catechin
PFTAWBLQPZVEMU-DZGCQCFKSA-N
Synonyms:
(2R,3S)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol, (2R,3S)-catechin, (RS)-catechin, 2,3-trans-catechin, D-catechin, p-catechuic acid

Show all pahtways known for Show all pathways known for (+)-catechin

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(2R,3S)-catechin + NADP+ + H2O = 2,3-trans-3,4-cis-leucocyanidin + NADPH + H+
show the reaction diagram

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-catechin + O2 = ?
show the reaction diagram
-
(2R,3S)-catechin + NADP+ + H2O = 2,3-trans-3,4-cis-leucocyanidin + NADPH + H+
show the reaction diagram
(+)-catechin + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
sucrose + (+)-catechin = D-fructose + (+)-catechin-3'-O-alpha-D-glucopyranoside
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.5 mM, 50% inhibition
-
50% inhibition of overall enzyme reaction at 1.6 mM, 50% inhibition of ketoacyl reduction reaction at 7.4 mM
-
a coumaroflavan from Treculia africana, 26% total inhibition at 0.033 mM
-
IC50: 0.44 mM
-
IC50: about 1.6 mM
-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

KM Value (9 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

IC50 Value (10 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.00122
-
pH 7.0, 23°C
0.0045
-
pH 7.5, 22°C
0.44
-
IC50: 0.44 mM
1.6
-
IC50: about 1.6 mM
0.046
-
-

References & Links

Links to other databases for (+)-catechin

ChEBI
PubChem
ChEBI
PubChem