Ligand (R)-2-hydroxyisocaproate

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Basic Ligand Information

Molecular Structure
Picture of (R)-2-hydroxyisocaproate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H12O3
(R)-2-hydroxyisocaproate
LVRFTAZAXQPQHI-RXMQYKEDSA-N
Synonyms:
(2R)-2-hydroxy-4-methylpentanoate, (2R)-hydroxy-4-methylpentanoate, (R)-2-hydroxy-4-methylpentanoate, 2-D-hydroxyisocaproate, D-2 -hydroxyisocaproate, D-2-hydroxy-4-methylvalerate


Show all pahtways known for Show all BRENDA pathways known for (R)-2-hydroxyisocaproate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-2 -hydroxyisocaproate + O2 = 2-oxoisocaproate + H2O2
show the reaction diagram
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4-methylpentanoyl-CoA + (R)-2-hydroxy-4-methylpentanoate = 4-methylpentanoate + (R)-2-hydroxy-4-methylpentanoyl-CoA
show the reaction diagram
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4-methylpent-2-enoyl-CoA + (R)-2-hydroxy-4-methylpentanoate = 4-methylpent-2-enoate + (R)-2-hydroxy-4-methylpentanoyl-CoA
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(R)-2-hydroxy-4-methylpentanoate + NAD+ = 4-methyl-2-oxopentanoate + NADH + H+
show the reaction diagram
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D-2 -hydroxyisocaproate + O2 = 2-oxoisocaproate + H2O2
show the reaction diagram
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(2R)-hydroxy-4-methylpentanoate + 2-oxo-butyrate = 2-oxo-4-methylpentanoate + (2R)-hydroxybutyrate
show the reaction diagram
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4-methylpentanoyl-CoA + (R)-2-hydroxy-4-methylpentanoate = 4-methylpentanoate + (R)-2-hydroxy-4-methylpentanoyl-CoA
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
4-methyl-2-oxopentanoate + NADH + H+ = (R)-2-hydroxy-4-methylpentanoate + NAD+
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
43
-
pH 7.0, temperature not specified in the publication

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
2.3
-
pH 7.0, temperature not specified in the publication

References & Links

Links to other databases for (R)-2-hydroxyisocaproate

ChEBI
PubChem
ChEBI
PubChem