Ligand fenthion

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of fenthion (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H15O3PS2
fenthion
PNVJTZOFSHSLTO-UHFFFAOYSA-N
Synonyms:
MPP

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
fenthion + NADPH + O2 = fenthion sulfoxide + NADP+ + H2O
-

Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE

Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
MPP precursor + H2O = MPP
-

Activator in Enzyme-catalyzed Reactions (1 result)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (1 result)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

KM Value (27 results)

COMMENTARY
EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
LITERATURE
wild-type enzyme, FMO3
0.145
-
wild-type enzyme, FMO1
0.34
-
mutant enzyme R502X, FMO1
0.3
-
mutant enzyme K158L/D132H, FMO3
0.22
-
mutant enzyme K158L, FMO3
0.2
-
mutant enzyme I303V, FMO1
0.351
-
mutant enzyme I303T, FMO1
0.24
-
mutant enzyme H97Q, FMO1
0.32
-
mutant enzyme D132H, FMO3
0.15
-
CYP3A4, sulfoxidation to fenthion-sulfoxide
0.131
-
sulfoxidation to fenthion-sulfoxide
desulfuration by recombinant human CYPs to fenthion-oxon
CYP1A1, at pH 7.4 and 37°C
0.008
-
CYP3A4, desulfuration by recombinant human CYPs to fenthion-oxon
0.089
-
CYP3A4, at pH 7.4 and 37°C
CYP2C9, sulfoxidation to fenthion-sulfoxide
0.006
-
CYP2C9, desulfuration by recombinant human CYPs to fenthion-oxon
0.012
-
CYP2C9, at pH 7.4 and 37°C
CYP2C19, sulfoxidation to fenthion-sulfoxide
0.0044
-
CYP2C19, desulfuration by recombinant human CYPs to fenthion-oxon
0.0024
-
CYP2C19, at pH 7.4 and 37°C
CYP1A1, sulfoxidation to fenthion-sulfoxide
0.008
-

Ki Value (2 results)

COMMENTARY
EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
LITERATURE
pH 7.5, 25°C, recombinant enzyme

IC50 Value (2 results)

COMMENTARY
EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
LITERATURE
pH 7.5, 25°C, recombinant enzyme

References & Links

Links to other databases for fenthion

ChEBI
PubChem
-
PubChem