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BRENDA support

Ligand tetrahydropteroylhexaglutamate

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Basic Ligand Information

Molecular Structure
Picture of tetrahydropteroylhexaglutamate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C44H58N12O21
tetrahydropteroylhexaglutamate
CSMSDHCIDKPAHS-DUJSLOSMSA-N
Synonyms:
5,6,7,8-tetrahydropteroyl-gamma-Glu6, 5,6,7,8-tetrahydropteroyl-Glu6, Tetrahydropteroylhexa-gamma-glutamate

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
10-formyltetrahydropteroylhexaglutamate + NADP+ + H2O = tetrahydropteroylhexaglutamate + CO2 + NADPH
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (1 result)

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EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
tetrahydropteroylhexaglutamate + 2-dehydropantoate = 5,10-methylenetetrahydropteroylhexaglutamate + 3-methyl-2-oxobutanoate + H2O
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (3 results)

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EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
10-formyltetrahydropteroylhexaglutamate + NADP+ + H2O = tetrahydropteroylhexaglutamate + CO2 + NADPH
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (1 result)

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EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
1 mol per mol of tetrameric protein, potent product inhibitor: 0.0003 mM, 90% inhibition
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Enzyme Kinetic Parameters

KM Value (1 result)

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EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.17
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References & Links

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Links to other databases for tetrahydropteroylhexaglutamate

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ChEBI
PubChem
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PubChem