print visible entries

print all entries

Ligand a [pre-mRNA]-containing guanosine-adenosine

Basic Ligand Information

close all tables

open all tables

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

top print hide

Show Natural Substrate (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

4.6.1.25

a [pre-mRNA]-containing guanosine-adenosine + H2O = a 5' hydroxy-guanosine-[pre-mRNA fragment] + a [pre-mRNA fragment]-3'-adenosine-3'-phosphate

758282, 756744

-

4.6.1.25

a [pre-mRNA]-containing guanosine-adenosine + H2O = a 5'-hydroxy-guanosine-[premRNA fragment] + a [pre-mRNA fragment]-3'-adenosine-3'-phosphate

754415, 754920, 754077

-

4.6.1.25

2 entries

Substrate in Enzyme-catalyzed Reactions (2 results)

top print hide

Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

4.6.1.25

a [pre-mRNA]-containing guanosine-adenosine + H2O = a 5' hydroxy-guanosine-[pre-mRNA fragment] + a [pre-mRNA fragment]-3'-adenosine-3'-phosphate

758282, 756744

-

4.6.1.25

a [pre-mRNA]-containing guanosine-adenosine + H2O = a 5'-hydroxy-guanosine-[premRNA fragment] + a [pre-mRNA fragment]-3'-adenosine-3'-phosphate

754415, 754920, 754077

-

4.6.1.25

2 entries

Enzyme Kinetic Parameters

References & Links

Literature References (9)

top print hide

Show Reference (9 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

754077

17046813

Structural and functional studies of RegB, a new member of a family of sequence-specific ribonucleases involved in mRNA inactivation on the ribosome

2007

Odaert, B.; Saida, F.; Aliprandi, P.; Durand, S.; Crechet, J.B.; Guerois, R.; Laalami, S.; Uzan, M.; Bontems, F.

J. Biol. Chem.

282

2019-2028

754415

10764573

Endoribonuclease RegB from bacteriophage T4 is necessary for the degradation of early but not middle or late mRNAs

2000

Sanson, B.; Hu, R.M.; Troitskayadagger, E.; Mathy, N.; Uzan, M.

J. Mol. Biol.

297

1063-1074

754415

10764573

Endoribonuclease RegB from bacteriophage T4 is necessary for the degradation of early but not middle or late mRNAs

2000

Sanson, B.; Hu, R.M.; Troitskayadagger, E.; Mathy, N.; Uzan, M.

J. Mol. Biol.

297

1063-1074

754920

12771201

The phage T4 restriction endoribonuclease RegB a cyclizing enzyme that requires two histidines to be fully active

2003

Saida, F.; Uzan, M.; Bontems, F.

Nucleic Acids Res.

31

2751-2758

754920

12771201

The phage T4 restriction endoribonuclease RegB a cyclizing enzyme that requires two histidines to be fully active

2003

Saida, F.; Uzan, M.; Bontems, F.

Nucleic Acids Res.

31

2751-2758

756744

7669340

Post-transcriptional controls in bacteriophage T4 roles of the sequence-specific endoribonuclease RegB

1995

Sanson, B.; Uzan, M.

FEMS Microbiol. Rev.

17

141-150

756744

7669340

Post-transcriptional controls in bacteriophage T4 roles of the sequence-specific endoribonuclease RegB

1995

Sanson, B.; Uzan, M.

FEMS Microbiol. Rev.

17

141-150

758282

14766312

First structural investigation of the restriction ribonuclease RegB NMR spectroscopic conditions, 13C/15N double-isotopic labelling and two-dimensional heteronuclear spectra

2004

Saida, F.; Odaert, B.; Uzan, M.; Bontems, F.

Protein Expr. Purif.

34

158-165

758282

14766312

First structural investigation of the restriction ribonuclease RegB NMR spectroscopic conditions, 13C/15N double-isotopic labelling and two-dimensional heteronuclear spectra

2004

Saida, F.; Odaert, B.; Uzan, M.; Bontems, F.

Protein Expr. Purif.

34

158-165

754415

2 entries

754920

2 entries

756744

2 entries

758282

2 entries

Links to other databases for a [pre-mRNA]-containing guanosine-adenosine

top print hide

Show Links (1 entry)