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Ligand a [DsbA protein] with reduced L-cysteine residues Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information
a [DsbA protein] with reduced L-cysteine residues
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)
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a [DsbA protein] with reduced L-cysteine residues + a quinone = a [DsbA protein] carrying a disulfide bond + a quinol
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a [DsbA protein] with reduced L-cysteine residues + a [DsbB protein] carrying a disulfide bond = a [DsbA protein] carrying a disulfide bond + a [DsbB protein] with reduced L-cysteine residues
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a [DsbA protein] with reduced L-cysteine residues + menaquinone = a [DsbA protein] carrying a disulfide bond + menaquinol
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a [DsbA protein] with reduced L-cysteine residues + ubiquinone = a [DsbA protein] carrying a disulfide bond + ubiquinol
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)
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a [DsbA protein] carrying a disulfide bond + a [protein] with reduced L-cysteine residues = a [DsbA protein] with reduced L-cysteine residues + a [protein] carrying a disulfide bond
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Substrate in Enzyme-catalyzed Reactions (6 results)
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a [DsbA protein] with reduced L-cysteine residues + a quinone = a [DsbA protein] carrying a disulfide bond + a quinol
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a [DsbA protein] with reduced L-cysteine residues + a [DsbB protein] carrying a disulfide bond = a [DsbA protein] carrying a disulfide bond + a [DsbB protein] with reduced L-cysteine residues
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a [DsbA protein] with reduced L-cysteine residues + menaquinone = a [DsbA protein] carrying a disulfide bond + menaquinol
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a [DsbA protein] with reduced L-cysteine residues + menaquinone-8 = a [DsbA protein] carrying a disulfide bond + menaquinol-8
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a [DsbA protein] with reduced L-cysteine residues + ubiquinone = a [DsbA protein] carrying a disulfide bond + ubiquinol
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a [DsbA protein] with reduced L-cysteine residues + ubiquinone-1 = a [DsbA protein] carrying a disulfide bond + ubiquinol-1
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Product in Enzyme-catalyzed Reactions (1 result)
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a [DsbA protein] carrying a disulfide bond + a [protein] with reduced L-cysteine residues = a [DsbA protein] with reduced L-cysteine residues + a [protein] carrying a disulfide bond
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Enzyme Kinetic Parameters
References & Links Literature References (6)
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Small molecule inhibitors of disulfide bond formation by the bacterial DsbA-DsbB dual enzyme system
2015
Halili, M.; Bachu, P.; Lindahl, F.; Bechara, C.; Mohanty, B.; Reid, R.; Scanlon, M.; Robinson, C.; Fairlie, D.; Martin, J.
ACS Chem. Biol.
10
957-964
Entropy-driven mechanisms between disulfide-bond formation protein A (DsbA) and B (DsbB) in Escherichia coli
2019
Yazawa, K.; Furusawa, H.
ACS Omega
4
8341-8349
Structure and mechanisms of the DsbB-DsbA disulfide bond generation machine
2008
Inaba, K.; Ito, K.
Biochim. Biophys. Acta Mol. Cell Res.
1783
520-529
Four cysteines of the membrane protein DsbB act in concert to oxidize its substrate DsbA
2002
Kadokura, H.; Beckwith, J.
EMBO J.
21
2354-2363
Reactivities of quinone-free DsbB from Escherichia coli
2005
Inaba, K.; Takahashi, Y.H.; Ito, K.
J. Biol. Chem.
280
33035-33044
Oxidative protein folding in bacteria
2002
Collet, J.; Bardwell, J.
Mol. Microbiol.
44
1-8
Links to other databases for a [DsbA protein] with reduced L-cysteine residues