Ligand Na+

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Basic Ligand Information

Molecular Structure
Picture of Na+ (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
Na
Na+
FKNQFGJONOIPTF-UHFFFAOYSA-N
Synonyms:
Na+/[side 1], Na+/[side 2], Na+in, Na+ in, Na+out, Na+ out, Na+out (n = 1-2), Na+[side 1], Na+[side 2], Na/+in, Na/+out, sodium

Show all pahtways known for Show all pathways known for Na+

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (26 results)

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EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(S)-methylmalonyl-CoA + Na+[side 1] + H+[side 2] = propanoyl-CoA + CO2 + Na+[side 2]
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (23 results)

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EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(S)-methylmalonyl-CoA + Na+[side 1] + H+[side 2] = propanoyl-CoA + CO2 + Na+[side 2]
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (60 results)

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EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(S)-methylmalonyl-CoA + Na+[side 1] + H+[side 2] = propanoyl-CoA + CO2 + Na+[side 2]
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (61 results)

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EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(S)-methylmalonyl-CoA + Na+[side 1] + H+[side 2] = propanoyl-CoA + CO2 + Na+[side 2]
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1003 results)

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EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
125 mM NaCl, 1.5 fold increase in activity
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activity is enhanced by 180% with Na+ (500 mM)
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up to 300 mM, slight activitation. Inhibitory above 500 mM
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activates, 100 mM
electron transfer from the [2Fe-2S] cluster to the Cys4[Fe] center and all subsequent steps are markedly accelerated when Na+ concentration is increased from 20 miroM to 25 mM

Inhibitor in Enzyme-catalyzed Reactions (1958 results)

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EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
10 mM, 13% loss of activity
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slight inhibitory effect at 5 mM
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slight inhibition at 1 mM
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slight inhibition at 70 mM
complete inhibition at 10 mM, no effect by Na+ at 1 mM
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slight inhibition at 1 mM
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competitive, forward reaction
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complete inhibition at 1 mM
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slight inhibition of extracellular enzyme
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slight inhibition at 1 mM
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