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Ligand 7-deoxycylindrospermopsin Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C1 5 H2 1 N5 O6 S
7-deoxycylindrospermopsin
UQRKOHUZCZBNCN-GATYQTQLSA-N
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)
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7-deoxycylindrospermopsin + 2-oxoglutarate + O2 = 7-epi-cylindrospermopsin + succinate + CO2
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7-deoxycylindrospermopsin + 2-oxoglutarate + O2 = cylindrospermopsin + succinate + CO2
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Substrate in Enzyme-catalyzed Reactions (2 results)
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7-deoxycylindrospermopsin + 2-oxoglutarate + O2 = 7-epi-cylindrospermopsin + succinate + CO2
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7-deoxycylindrospermopsin + 2-oxoglutarate + O2 = cylindrospermopsin + succinate + CO2
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Inhibitor in Enzyme-catalyzed Reactions (2 results)
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the enzyme is strongly inhibited by 7-deoxycylindrospermopsin at concentration higher than 0.001 mM
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Enzyme Kinetic Parameters
KM Value (2 results)
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0.0012
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pH and temperature not specified in the publication
Ki Value (1 result)
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0.036
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pH and temperature not specified in the publication
References & Links Literature References (2)
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Characterization of CyrI, the hydroxylase involved in the last step of cylindrospermopsin biosynthesis Binding studies, site-directed mutagenesis and stereoselectivity
2018
Mazmouz, R.; Essadik, I.; Hamdane, D.; Mejean, A.; Ploux, O.
Arch. Biochem. Biophys.
647
1-9
The last step of the biosynthesis of the cyanotoxins cylindrospermopsin and 7-epi-cylindrospermopsin is catalysed by CyrI, a 2-oxoglutarate-dependent iron oxygenase
2011
Mazmouz, R.; Chapuis-Hugon, F.; Pichon, V.; Mejean, A.; Ploux, O.
ChemBioChem
12
858-862
Links to other databases for 7-deoxycylindrospermopsin