BRENDA home

Basic Ligand Information
Roles as Enzyme Ligand
Enzyme Kinetic Parameters
References & Links
- References
- Links

print all entries

Ligand an ultra-long-chain di-unsaturated acyl-[acyl-carrier protein]

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Formula

BRENDA Name

InChIKey

an ultra-long-chain di-unsaturated acyl-[acyl-carrier protein]

close all tables

open all tables

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

top print hide

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

Show Natural Substrate (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.294

an ultra-long-chain di-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = an ultra-long-chain di-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]

754063, 754075, 754417, 754769, 754770, 755624, 755623, 752750

2.3.1.294

an ultra-long-chain di-unsaturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein AcpM] = an ultra-long-chain di-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein AcpM]

754094

2.3.1.294

an ultra-long-chain di-unsaturated acyl-[acyl-carrier protein] + palmitoyl-[acyl-carrier protein AcpM] = an ultra-long-chain di-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein AcpM]

754094

2.3.1.294

3 entries

Substrate in Enzyme-catalyzed Reactions (3 results)

top print hide

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.294

754063, 754075, 754417, 754769, 754770, 755624, 755623, 752750

Enzyme Kinetic Parameters

References & Links

Literature References (9)

top print hide

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

Show Reference (9 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

752750

22017312

Substrate recognition by beta-ketoacyl-ACP synthases

2011

Borgaro, J.; Chang, A.; MacHutta, C.; Zhang, X.; Tonge, P.

Biochemistry

10678-10686

754063

11600501

Purification and biochemical characterization of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthases KasA and KasB

2001

Schaeffer, M.L.; Agnihotri, G.; Volker, C.; Kallender, H.; Brennan, P.J.; Lonsdale, J.T.

J. Biol. Chem.

276

47029-47037

754075

16873379

The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation

2006

Molle, V.; Brown, A.; Besra, G.; Cozzone, A.; Kremer, L.

J. Biol. Chem.

281

30094-30103

754094

20018879

Slow onset inhibition of bacterial beta-ketoacyl-acyl carrier protein synthases by thiolactomycin

2010

Machutta, C.A.; Bommineni, G.R.; Luckner, S.R.; Kapilashrami, K.; Ruzsicska, B.; Simmerling, C.; Kisker, C.; Tonge, P.J.

J. Biol. Chem.

285

6161-6169

754417

17174327

X-ray crystal structure of Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase II (mtKasB)

2007

Sridharan, S.; Wang, L.; Brown, A.; Dover, L.; Kremer, L.; Besra, G.; Sacchettini, J.

J. Mol. Biol.

366

469-480

754769

12950920

Requirement for kasB in Mycobacterium mycolic acid biosynthesis, cell wall impermeability and intracellular survival implications for therapy

2003

Gao, L.Y.; Laval, F.; Lawson, E.H.; Groger, R.K.; Woodruff, A.; Morisaki, J.H.; Cox, J.S.; Daffe, M.; Brown, E.J.

Mol. Microbiol.

1547-1563

754770

17555433

The Mycobacterium tuberculosis FAS-II condensing enzymes Their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development

2007

Bhatt, A.; Molle, V.; Besra, G.; Jacobs Jr., W.; Kremer, L.

Mol. Microbiol.

1442-1454

755623

12464486

The role of KasA and KasB in the biosynthesis of meromycolic acids and isoniazid resistance in Mycobacterium tuberculosis

2002

Slayden, R.; Barry III, C.

Tuberculosis

149-160

755624