Ligand ganglioside GD3

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Basic Ligand Information

Molecular Structure
Picture of ganglioside GD3 (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C70H125N3O29
ganglioside GD3
CSXAHYACQIWDLT-NGULNDEDSA-N
Synonyms:
GD3, GD3 ganglioside, GD3(N-acetylneuraminic acid), GD3-ganglioside
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl-CoA + ganglioside GD3 = CoA + 9'-O-acetyl-ganglioside GD3 + CoA
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
CMP-N-acetylneuraminate + ganglioside GM3 = CMP + ganglioside GD3
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl-CoA + ganglioside GD3 = CoA + 4-O-acetylated ganglioside GD3
show the reaction diagram
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ganglioside GD3 + H2O = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
CMP-N-acetylneuraminate + ganglioside GM3 = CMP + ganglioside GD3
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
exogenous ganglioside, inhibition in vivo
-

Enzyme Kinetic Parameters

KM Value (3 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0012
-
-

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.066
-
inhibition of GM2 synthesis, pH 7.35, 37°C

References & Links

Links to other databases for ganglioside GD3

ChEBI
PubChem
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PubChem