Ligand a [histone H3]-N6-methyl-L-lysine27

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Basic Ligand Information

Molecular Structure
Picture of a [histone H3]-N6-methyl-L-lysine27 (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C33H58N12O9R2
a [histone H3]-N6-methyl-L-lysine27
Synonyms:
[histone H3]-N6-methyl-L-lysine27, [histone H3]-N6-methyl-L-lysine 27

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + [histone H3]-N6-methyl-L-lysine27 = S-adenosyl-L-homocysteine + [histone H3]-N6,N6-dimethyl-L-lysine27
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
[histone H3]-N6,N6-dimethyl-L-lysine27 + 2-oxoglutarate + O2 = [histone H3]-N6-methyl-L-lysine27 + succinate + formaldehyde + CO2
show the reaction diagram
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[histone H3]-N6,N6-dimethyl-L-lysine 27 + 2-oxoglutarate + O2 = [histone H3]-N6-methyl-L-lysine 27 + succinate + formaldehyde + CO2
show the reaction diagram
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S-adenosyl-L-methionine + [histone H3]-L-lysine27 = S-adenosyl-L-homocysteine + [histone H3]-N6-methyl-L-lysine27
show the reaction diagram
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S-adenosyl-L-methionine + [histone H3]-L-lysine27 = S-adenosyl-L-homocysteine + [histone H3]-N6-methyl-L-lysine27
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Product in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
[histone H3]-N6,N6-dimethyl-L-lysine27 + 2-oxoglutarate + O2 = [histone H3]-N6-methyl-L-lysine27 + succinate + formaldehyde + CO2
show the reaction diagram
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S-adenosyl-L-methionine + [histone H3]-L-lysine27 = S-adenosyl-L-homocysteine + [histone H3]-N6-methyl-L-lysine27
show the reaction diagram
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Enzyme Kinetic Parameters

References & Links

Links to other databases for a [histone H3]-N6-methyl-L-lysine27

ChEBI
PubChem
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