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Inhibitors of glyoxalase enzymes
1980
Oray, B.; Norton, S.J.
Biochem. Biophys. Res. Commun.
95
624-629
Some enzymes of nucleoside metabolism of Escherichia coli
1956
Koch, A.L.
J. Biol. Chem.
223
535-549
-
Purine salvage enzymes in man and Leishmania donovani
1980
Krenitsky, T.A.; Koszalka, G.W.; Tuttle, J.V.; Adamczyk, D.L.; Elion, G.B.; Marr, J.J.
Adv. Exp. Med. Biol.
122
51-56
Nucleosidases from Leishmania donovani. Pyrimidine ribonucleosidase, purine ribonucleosidase, and a novel purine 2-deoxyribonucleosidase
1979
Koszalka, G.W.; Krenitsky, T.A.
J. Biol. Chem.
254
8185-8193
Purification and properties of nucleoside hydrolase from Pseudomonas fluorescens
1967
Terada, M.; Tatibana, M.; Hayaishi, O.
J. Biol. Chem.
242
5578-5585
-
Some properties of adenine deaminase of Pseudomonas synxantha
1979
Jun, H.K.; Sakai, T.
J. Ferment. Technol.
57
294-299
-
Purification and characterisation of adenine deaminase in Pseudomonas synxantha
1978
Sakai, T.; Jun, H.K.
J. Ferment. Technol.
56
257-265
-
Purification and characterization of guanine aminohydrolase from human liver
1985
Kimm, S.W.; Park, J.B.; Lee, I.S.
Korean J. Biochem.
17
139-148
Guanine deaminase from rat brain. Purification, characteristics, and contribution to ammoniagenesis in the brain
1982
Miyamoto, S.; Ogawa, H.; Shiraki, H.; Nakagawa, H.
J. Biochem.
91
167-176
Uricase and allantoinase in glyoxysomes
1971
Theimer, R.R.; Beevers, H.
Plant Physiol.
47
246-251
Xanthine oxidase and aldehyde oxidase: A simple procedure for the simultaneous purification from rat liver
2002
Maia, L.; Mira, L.
Arch. Biochem. Biophys.
400
48-53
Retinal oxidase is identical to aldehyde oxidase
1993
Tomita, S.; Tsujita, M.; Ichikawa, Y.
FEBS Lett.
336
272-274
The structure of the molybdenum cofactor. Characterization of di-(carboxamidomethyl)molybdopterin from sulfite oxidase and xanthine oxidase
1987
Kramer, S.P.; Johnson, J.L.; Ribeiro, A.A.; Millington, D.S.; Rajagopalan, K.V.
J. Biol. Chem.
262
16357-16363
Characterization of the molybdenum cofactor of sulfite oxidase, xanthine, oxidase, and nitrate reductase. Identification of a pteridine as a structural component
1980
Johnson, J.L.; Hainline, B.E.; Rajagopalan, K.V.
J. Biol. Chem.
255
1783-1786
-
Molybdenum iron-sulfur flavin hydroxylases and related enzymes
1975
Bray, R.C.
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
12
299-419
Purification and properties of urate oxidase from Streptomyces cyanogenus
1981
Ohe, T.; Watanabe, Y.
J. Biochem.
89
1769-1776
Purification and some properties of urate oxidase from nitrogen-fixing nodules of cowpea
1981
Rainbird, R.M.; Atkins, C.A.
Biochim. Biophys. Acta
659
132-140
Uricase of Bacillus fastidiosus. Properties and regulation of synthesis
1978
Bongaerts, G.P.A.; Uitzetter, J.; Brouns, R.; Vogels, G.D.
Biochim. Biophys. Acta
527
348-358
Kinetic mechanism and cofactor content of soybean root nodule urate oxidase
1997
Kahn, K.; Tipton, P.A.
Biochemistry
36
4731-4738
Urate oxidase from the rust Puccinia recondita is a heterotetramer with two different-sized monomers
2002
Aguilar, M.; Montalbini, P.; Pineda, M.
Curr. Microbiol.
44
257-261
-
Uricase from leaves. Its purification and characterization from three different higher plants
1997
Montalbini, P.; Redondo, J.; Caballero, J.L.; Cardenas, J.; Pineda, M.
Planta
202
277-283
-
Isolation and characterization of uricase from bean leaves and its comparison with uredospore enzymes
1999
Montalbini, P.; Aguilar, M.; Pineda, M.
Plant Sci.
147
139-147
Purification and properties of a new glutathione-dependent thiol:disulphide oxidoreductase from rat liver
1982
Battelli, M.G.; Lorenzoni, E.
Biochem. J.
207
133-138
-
Detection of a pteridine oxidase in plants
1980
Hong, Y.N.
Plant Sci. Lett.
18
169-175
Xanthosine and xanthine. Substrate properties with purine nucleoside phosphorylases, and relevance to other enzyme systems
2002
Stoychev, G.; Kierdaszuk, B.; Shugar, D.
Eur. J. Biochem.
269
4048-4057
3-Ribosylpurines. I.Synthesis of (3-ribosyluric acid) 5´phosphate and (3-ribosylxanthine) 5´phosphate by a pyrimidine ribonucleotide pyrophosphorylase
1964
Hatfield, D.; Wyngaarden, J.B.
J. Biol. Chem.
239
2580-2586
Guanine and xanthine phosphoribosyltransfer activities of Lactobacillus casei and Escherichia coli. Their relationship to hypoxanthine and adenine phosphoribosyltransfer activities
1970
Krenitsky, T.A.; Neil, S.M.; Miller, R.L.
J. Biol. Chem.
245
2605-2611
Xanthine phosphoribosyltransferase in Leishmania: divalent cation activation
1982
Kidder, G.W.; Nolan, L.L.
J. Protozool.
29
405-409
Purine phosphoribosyltransferases from Leishmania donovani
1980
Tuttle, J.V.; Krenitsky, T.A.
J. Biol. Chem.
255
909-916
Xanthine phosphoribosyltransferase from Streptococcus faecalis. Properties and specificity
1974
Miller, R.L.; Adamczyk, D.L.; Fyfe, J.A.; Elion, G.B.
Arch. Biochem. Biophys.
165
349-358
Crystal structure of Escherichia coli xanthine phosphoribosyltransferase
1997
Vos, S.; de Jersey, J.; Martin, J.L.
Biochemistry
36
4125-4134
Isolation and characterization of the Saccharomyces cerevisiae XPT1 gene encoding xanthine phosphoribosyl transferase
1999
Guetsova, M.L.; Crother, T.R.; Taylor, M.W.; Daignan-Fornier, B.
J. Bacteriol.
181
2984-2986
Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyltransferase from Toxoplasma gondii
1995
Naguib, F.N.M.; Iltzsch, M.H.; el Kouni, M.M.; Panzica, R.P.; el Kouni, M.H.
Biochem. Pharmacol.
50
1685-1693
Xanthine phosphoribosyltransferase from Leishmania donovani. Molecular cloning, biochemical characterization, and genetic analysis
1999
Jardim, A.; Bergeson, S.E.; Shih, S.; Carter, N.; Lucas, R.W.; Merlin, G.; Myler, P.J.; Stuart, K.; Ullman, B.
J. Biol. Chem.
274
34403-34410
Purification and properties of trans-N-deoxyribosylase
1958
Roush, A.H.; Betz, R.F.
J. Biol. Chem.
233
261-266
Nucleoside deoxyribosyltransferase from Lactobacillus helveticus
1978
Cardinaud, R.
Methods Enzymol.
51
446-455
trans-N-Deoxyribosylase: substrate specificity studies. Purine bases as acceptors
1975
Holguin, J.; Cardinaud, R.
Eur. J. Biochem.
54
515-520
-
Purification and characterization of an adenine phosphoribosyltransferase from rubber tree latex. Physiological implications
1996
Gallois, R.; Prevot, J.C.; Clement, A.; Jacob, J.L.
Plant Physiol. Biochem.
34
527-537
-
Nucleotide synthesis from 5-phosphoribosylpyrophosphate
1963
Flaks, J.G.
Methods Enzymol.
6
136-158
Purification of hypoxanthine-guanine phosphoribosyltransferase of Plasmodium lophurae
1987
Schimandle, C.M.; Mole, L.A.; Sherman, I.W.
Mol. Biochem. Parasitol.
23
39-45
Hypoxanthine phosphoribosyltransferase and guanine phosphoribosyltransferase from enteric bacteria
1978
Hochstadt, J.
Methods Enzymol.
51
549-558
-
Purification and properties of hypoxanthine phosphoribosyltransferase from Streptomyces cyanogenus
1980
Ohe, T.; Watanabe, Y.
Agric. Biol. Chem.
44
1999-2006
Guanine phosphoribosyltransferase from Escherichia coli, specificity and properties
1972
Miller, R.L.; Ramsey, G.A.; Krenitsky, T.A.; Elion, G.B.
Biochemistry
11
4723-4731
Purification and characterization of hypoxanthine-guanine phosphoribosyltransferase from Saccharomyces cerevisiae
1981
Nussbaum, R.L.; Caskey, C.T.
Biochemistry
20
4584-4590
Purification and characterization of guanine phosphoribosyltransferase from Giardia lamblia
1986
Aldritt, S.M.; Wang, C.C.
J. Biol. Chem.
261
8528-8533
Crystal structure of Toxoplasma gondii hypoxanthine-guanine phosphoribosyltransferase with XMP, pyrophosphate, and two Mg2+ Ions Bound: insights into the catalytic mechanism
1999
Heroux, A.; White, E.L.; Ross, L.J.; Davis, R.L.; Borhani, D.W.
Biochemistry
38
14495-14506
Crystal structures of the Toxoplasma gondii hypoxanthine-guanine phosphoribosyltransferase-GMP and -IMP complexes: comparison of purine binding interactions with the XMP complex
1999
Heroux, A.; White, E.L.; Ross, L.J.; Borhani, D.W.
Biochemistry
38
14485-14494
Steady-state kinetics of the hypoxanthine-guanine-xanthine phosphoribosyltransferase from Tritrichomonas foetus: the role of threonine-47
1998
Munagala, N.R.; Chin, M.S.; Wang, C.C.
Biochemistry
37
4045-4051
Hypoxanthine, guanine, xanthine phosphoribosyltransferase activity in Cryptosporidium parvum
1998
Doyle, P.S.; Kanaani, J.; Wang, C.C.
Exp. Parasitol.
89
9-15
Altering the purine specificity of hypoxanthine-guanine-xanthine phosphoribosyltransferase from Tritrichomonas foetus by structure-based point mutations in the enzyme protein
1998
Munagala, N.R.; Wang, C.C.
Biochemistry
37
16612-16619
Purification and characterization of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase and comparison with the human enzyme
1999
Keough, D.T.; Ng, A.L.; Winzor, D.J.; Emmerson, B.T.; de Jersey, J.
Mol. Biochem. Parasitol.
98
29-41
Point mutations in the guanine phosphoribosyltransferase from Giardia lamblia modulate pyrophosphate binding and enzyme catalysis
1999
Page, J.P.; Munagala, N.R.; Wang, C.C.
Eur. J. Biochem.
259
565-571
Unusual substrate specificity of a chimeric hypoxanthine-guanine phosphoribosyltransferase containing segments from the Plasmodium falciparum and human enzymes
2000
Sujay Subbayya, I.N.; Sukumaran, S.; Shivashankar, K.; Balaram, H.
Biochem. Biophys. Res. Commun.
272
596-602
An intestinal phosphorylase for uric ribonucleoside
1963
Laster, L.; Blair, A.
J. Biol. Chem.
238
3348-3357
-
Purification, crystallization and preliminary X-ray diffraction studies of xanthine dehydrogenase and xanthine oxidase isolated from bovine milk
2000
Eger, B.T.; Okamoto, K.; Enroth, C.; Sato, M.; Nishino, T.; Pai, E.F.; Nishino, T.
Acta Crystallogr. Sect. D
56
1656-1658
Kinetic mechanism of chicken liver xanthine dehydrogenase
1988
Bruguera, P.; Lopez-Cabrera, A.; Canela, E.I.
Biochem. J.
249
171-178
-
Distribution of xanthine dehydrogenase and oxidase activities in human and rabbit tissues
1988
Wajner, M.; Harkness, R.A.
Biochem. Soc. Trans.
16
358-359
Distribution of xanthine dehydrogenase and oxidase activities in human and rabbit tissues
1989
Wajner, M.; Harkness, R.A.
Biochim. Biophys. Acta
991
79-84
Proteolytic conversion of xanthine dehydrogenase to xanthine oxidase: Evidence against a role for calcium-activated protease (calpain)
1989
Stark, K.; Seubert, P.; Lynch, G.; Baudry, M.
Biochem. Biophys. Res. Commun.
165
858-864
Expression of Drosophila melanogaster xanthine dehydrogenase in Aspergillus nidulans and some properties of the recombinant enzyme
2002
Adams, B.; Lowe, D.J.; Smith, A.T.; Scazzocchio, C.; Demais, S.; Bray, R.C.
Biochem. J.
362
223-229
-
Purification and characterization of a microbial xanthine dehydrogenase highly active towards hypoxanthine
1989
Kim, J.M.; Schmid, R.D.
GBF Monogr. , Biosens. Appl. Med. , Environ. Prot. Process Control
13
421-424
Xanthine dehydrogenase from Pseudomonas putida 86: Specificity, oxidation-reduction potentials of its redox-active centers, and first EPR characterization
2001
Parschat, K.; Canne, C.; Huttermann, J.; Kappl, R.; Fetzner, S.
Biochim. Biophys. Acta
1544
151-165
Identification of xanthine dehydrogenase/xanthine oxidase as a rat paneth cell zinc-binding protein
2001
Morita, Y.; Sawada, M.; Seno, H.; Takaishi, S.; Fukutawa, H.; Miyake, N.; Hiai, H.; Chiba, T.
Biochim. Biophys. Acta
1540
43-49
Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: Structure-based mechanism of conversion
2000
Enroth, C.; Eger, B.T.; Okamoto, K.; Nishino, T.; Nishino, T.; Pai, E.F.
Proc. Natl. Acad. Sci. USA
97
10723-10728
Mouse mammary gland xanthine oxidoreductase: Purification, characterization, and regulation
1999
McManaman, J.L.; Neville, M.C.; Wright, R.M.
Arch. Biochem. Biophys.
371
308-316
Selenium-containing xanthine dehydrogenase from Eubacterium barkeri
1999
Schräder, T.; Rienhöfer, A.; Andreesen, J.R.
Eur. J. Biochem.
264
862-871
Inhibition of xanthine oxidase and xanthine dehydrogenase by nitric oxid
1999
Ichimori, K.; Fukahori, M.; Nakazawa, H.; Okamoto, K.; Nishino, T.
J. Biol. Chem.
274
7763-7768
-
Purification and some properties of xanthine dehydrogenase from wheat leaves
1998
Montalbini, P.
Plant Sci.
134
89-102
Xanthine metabolism in Bacillus subtilis: Characterization of the xpt-pbuX operon and evidence for purine- and nitrogen-controlled expression of genes involved in the xanthine salvage and catabolism
1997
Christiansen, L.C.; Schou, S.; Nygaard, P.; Saxild, H.H.
J. Bacteriol.
179
2540-2550
Characterization of xanthine dehydrogenase from the anaerobic bacterium Veillonella atypica and identification of molybdopterin-cytosine-dinucleotide-containing molybdenum cofactor
1996
Gremer, L.; Meyer, O.
Eur. J. Biochem.
238
862-866
Purification of xanthine dehydrogenase from rat liver: A rapid procedure with high enzyme yields
1987
Suleiman, S.A.; Stevens, J.B.
Arch. Biochem. Biophys.
258
219-225
Subunit constitution of electrophoretically purified xanthine dehydrogenase of avian liver
1984
Irie, S.
J. Biochem.
95
405-412
Occurrence of an NADH diaphorase activity associated with xanthine dehydrogenase in Chlamydomonas reinhardtii
1987
Prez-Vicente, R.; Pineda, M.; Cardenas, J.
FEMS Microbiol. Lett.
43
321-325
Effects of limited proteolysis on the structure and activity of turkey liver xanthine dehydrogenase
1977
Fhaolain, I.N.; Coughlan, M.P.
Biochem. Soc. Trans.
5
1705-1707
Cloning and partial characterization of the xanthine dehydrogenase gene of Calliphora vicina, a distant relative of Drosophila melanogaster
1987
Rocher-Chambonnet, C.; Berreur, P.; Houde, M.; Tiveron, M.C.; Lepesant, J.A.; Bregegere, F.
Gene
59
201-212
Rapid reaction studies on the reduction and oxidation of chicken liver xanthine dehydrogenase by the xanthine/urate and NAD/NADH couples
1988
Schopfer, L.M.; Massey, V.; Nishino, T.
J. Biol. Chem.
263
13528-13538
Selenium-dependent metabolism of purines: A selenium-dependent purine hydroxylase and xanthine dehydrogenase were purified from Clostridium purinolyticum and characterized
2000
Self, W.T.; Stadtman, T.C.
Proc. Natl. Acad. Sci. USA
97
7208-7213
-
Use of rosy mutant strains of Drosophila melanogaster to probe the structure and function of xanthine dehydrogenase
1992
Hughes, R.K.; Doyle, W.A.; Chovnick, A.; Whittle, J.R.S.; Burke, J.F.; Bray, R.C.
Biochem. J.
285
507-513
Purification and properties of chicken liver xanthine dehydrogenase
1967
Rajagopalan, K.V.; Handler, P.
J. Biol. Chem.
242
4097-4107
Purification and properties of the NAD+-dependent (type D) and O2-dependent (type O) forms of rat liver xanthine dehydrogenase
1976
Waud, W.R.; Rajagopalan, K.V.
Arch. Biochem. Biophys.
172
354-364
Purification and properties of xanthine dehydrogenase from Pseudomonas acidovorans
1975
Sin, I.L.
Biochim. Biophys. Acta
410
12-20
The regulation of rat liver xanthine oxidase. Involvement of thiol groups in the conversion of the enzyme activity from dehydrogenase (type D) into oxidase (type O) and purification of the enzyme
1972
Della Corte, E.; Stirpe, F.
Biochem. J.
126
739-745
Purification and characterization of a prokaryotic xanthine dehydrogenase from Comamonas acidovorans
1996
Xiang, Q.; Edmondson, D.E.
Biochemistry
35
5441-5450
Properties of xanthine dehydrogenase variants from rosy mutant strains of Drosophila melanogaster and their relevance to the enzyme's structure and mechanism
1996
Doyle, W.A.; Burke, J.F.; Chovnick, A.; Dutton, F.L.; Whittle, J.R.S.; Bray, R.C.
Eur. J. Biochem.
239
782-795
Molybdenum cofactor mutants, specifically impaired in xanthine dehydrogenase activity and abscisic acid biosynthesis, simultaneously overexpress nitrate reductase
1995
Leydecker, M.T.; Moureaux, T.; Kraepiel, Y.; Schnorr, K.; Caboche, M.
Plant Physiol.
107
1427-1431
The mechanism of conversion of rat liver xanthine dehydrogenase from an NAD+-dependent form (type D) to an O2-dependent form (type O)
1976
Waud, W.R.; Rajagopalan, K.V.
Arch. Biochem. Biophys.
172
365-379
Purification and properties of milk xanthine dehydrogenase
1992
Hunt, J.; Massey, V.
J. Biol. Chem.
267
21479-21485
-
Some properties and subcellular localization of xanthine dehydrogenase in pea leaves
1978
Nguyen, J.; Feierabend, J.
Plant Sci. Lett.
13
125-132
Purification and substrate inactivation of xanthine dehydrogenase from Chlamydomonas reinhardtii
1992
Perez-Vicente, R.; Alamillo, J.M.; Cardenas, J.; Pineda, M.
Biochim. Biophys. Acta
1117
159-166
Characterization of cultured alveolar epithelial cell xanthine dehydrogenase/oxidase
1991
Panus, P.C.; Burgess, B.; Freeman, B.A.
Biochim. Biophys. Acta
1091
303-309
-
Purification and characterization of xanthine dehydrogenase from Clostridium acidiurici grown in the presence of selenium
1984
Wagner, R.; Cammack, R.; Andreesen, J.R.
Biochim. Biophys. Acta
791
63-74
Purification and properties of a novel ferricyanide-linked xanthine dehydrogenase from Pseudomonas putida 40
1985
Woolfolk, C.A.
J. Bacteriol.
163
600-609
Distribution of xanthine oxidase and xanthine dehydrogenase specificity types among bacteria
1977
Woolfolk, C.A.; Downard, J.S.
J. Bacteriol.
130
1175-1191
Electrophoretic variants of xanthine dehydrogenase in Drosophila melanogaster: II. Enzyme kinetics
1967
Yen, T.T.T.; Glassman, E.
Biochim. Biophys. Acta
146
35-44
Purification and properties of xanthine dehydrogenase from Micrococcus lactilyticus
1967
Smith, S.T.; Rajagopalan, K.V.; Handler, P.
J. Biol. Chem.
242
4108-4117
Xanthine dehydrogenase from Drosophila melanogaster: Purification and properties of the wild-type enzyme and of a variant lacking iron-sulfur centers
1992
Hughes, R.K.; Bennett, B.; Bray, R.C.
Biochemistry
31
3073-3083
Effect of NADH on hypoxanthine hydroxylation by native NAD+-dependent xanthine oxidoreductase of rat liver, and the possible biological role of this effect
1981
Kaminski, Z.W.; Jezewska, M.M.
Biochem. J.
200
597-603
Involvement of a single thiol group in the conversion of the NAD+-dependent activity of rat liver xanthine oxidoreductase to the O2-dependent activity
1982
Kaminsky, Z.W.; Jezewska, M.M.
Biochem. J.
207
341-346
Liver xanthine dehydrogenase and iron mobilization
1982
Topham, R.W.; Walker, M.C.; Calisch, M.
Biochem. Biophys. Res. Commun.
109
1240-1246
Crystal structures of the active and alloxanthine-inhibited forms of xanthine dehydrogenase from Rhodobacter capsulatus
2002
Truglio, J.J.; Theis, K.; Leimkuhler, S.; Rappa, R.; Rajagopalan, K.V.; Kisker, C.
Structure
10
115-125
Regulation, purification, and properties of xanthine dehydrogenase in Neurospora crassa
1978
Lyon, E.S.; Garrett, R.H.
J. Biol. Chem.
253
2604-2614
Purification of xanthine dehydrogenase from Drosophila melanogaster
1964
Parzen, S.D.; Fox, A.S.
Biochim. Biophys. Acta
92
465-471
-
Xanthine dehydrogenase in chicken liver: Its subcelluar localization ant its possible role on gluconeogenesis from amino acids
1981
Coolbear, K.P.; Herzberg, G.R.; Brosnan, J.T.
Biochem. Soc. Trans.
9
394-395
Xanthine dehydrogenase and pteridine metabolism in Colias butterflies
1972
Watt, W.B.
J. Biol. Chem.
247
1445-1451
-
Molecular and kinetic characterization of xanthine dehydrogenase from the phototrophic bacterium Rodopseudomonas capsulata
1981
Aretz, W.; Kaspari, H.; Klemme, J.H.
Z. Naturforsch. C
36
933-941
Soybean nodule xanthine dehydrogenase: A kinetic study
1983
Boland, M.J.; Blevins, D.G.; Randall, D.D.
Arch. Biochem. Biophys.
222
435-441
Xanthine dehydrogenase from Drosophila melanogaster. A comparison of the kinetic parameters of the pure enzyme from two wild-type isoalleles differing at a putative regulatory site
1977
Edwards, T.C.R.; Candido, E.P.M.
Mol. Gen. Genet.
154
1-6
Occurrence of xanthine dehydrogenase in Chlamydomonas reinhardii: A common cofactor shared by xanthine dehydrogenase and nitrate reductase
1981
Fernandez, E.; Cardenas, J.
Planta
153
254-257
Kinetics and stability of immobilized chicken liver xanthine dehydrogenase
1979
Tramper, J.; Angelino, S.A.G.F.; Muller, F.; van der Plas, H.C.
Biotechnol. Bioeng.
21
1767-1786
Selenium requirement for active xanthine dehydrogenase from Clostridium acidiurici and Clostridium cylindrosporum
1979
Wagner, R.; Andreesen, J.R.
Arch. Microbiol.
121
255-260
The inactivation of xanthine-oxidizing enzymes, native and deflavo forms, in the presence of oxygen
1979
Coughlan, M.P.; Johnson, D.B.
Biochem. Soc. Trans.
7
18-21
Purification and properties of xanthine dehydrogenase from Streptomyces cyanogenus
1979
Ohe, T.; Watanabe, Y.
J. Biochem.
86
45-53
-
Purification, crystallization, and some properties of xanthine dehydrogenase from Pseudomonas synxantha A 3
1979
Sakai, T.; Jun, H.K.
Agric. Biol. Chem.
43
753-760
Preparation of bovine milk xanthine oxidase as a dehydrogenase form
1982
Nakamura, M.; Yamazaki, I.
J. Biochem.
92
1279-1286
Crystal structure of the xanthine oxidase-related aldehyde oxido-reductase from D. gigas
1995
Romao, M.J.; Archer, M.; Moura, I.; Moura, J.J.G.; Legall, J.; Engh, R.; Schneider, M.; Hof, P.; Huber, R.
Science
270
1170-1176
Xanthine oxidase in lentil (Lens esculenta) seedlings
1977
Taneja, R.; Taneja, V.
Biochim. Biophys. Acta
485
489-491
Bacterial xanthine oxidase from Arthrobacter S-2
1978
Woolfolk, C.A.; Downard, J.S.
J. Bacteriol.
135
422-428
Bovine milk xanthine oxidase: purification by ultrafiltration and conventional methods which omit addition of proteases: some criteria for homogeneity of native xanthine oxidase
1978
Nathans, G.R.; Hade, E.P.K.
Biochim. Biophys. Acta
526
328-344
-
Purification and properties of xanthine oxidase from Enterobacter cloacae
1981
Machida, Y.; Nakanishi, T.
Agric. Biol. Chem.
45
425-432
Characteristics of membrane-bound and soluble forms of xanthine oxidase from milk and endothelial cells of capillaries
1982
Bruder, G.; Heid, H.; Jarasch, E.D.; Keenan, T.W.; Mather, I.H.
Biochim. Biophys. Acta
701
357-369
Xanthine oxidase from human liver: purification and characterization
1986
Krenitsky, T.A.; Spector, T.; Hall, W.W.
Arch. Biochem. Biophys.
247
108-119
Purification of the bovine xanthine oxidoreductase from milk fat globule membranes and cloning of complementary deoxyribonucleic acid
1996
Berglund, L.; Rasmussen, J.T.; Andersen, M.D.; Rasmussen, M.S.; Petersen, T.E.
J. Dairy Sci.
79
198-204
Xanthine oxidase binding to glycosaminoglycans: kinetics and superoxide dismutase interactions of immobilized xanthine oxidase-heparin complexes
1997
Radi, R.; Rubbo, H.; Bush, K.; Freeman, B.A.
Arch. Biochem. Biophys.
339
125-135
Simple, high-yield purification of xanthine oxidase from bovine milk
1999
Ízer, N.; Muftuoglu, M.; Ataman, D.; Ercan, A.; Ígus, I.H.
J. Biochem. Biophys. Methods
39
153-159
Binding of xanthine oxidase to vascular endothelium
1999
Houston, M.; Esteveze, A.; Chumley, P.; Aslan, M.; Marklund, S.; Parks, D.A.; Freeman, B.A.
J. Biol. Chem.
274
4985-4994
Enzyme inhibiton and protein-binding action of the procyanidin-rich french maritime pine bark extract, pycnogenol: effect on xanthine oxidase
2000
Moini, H.; Guo, Q.; Packer, L.
J. Agric. Food Chem.
48
5630-5639
Cellular distribution, metabolism and regulation of the xanthine oxidoreductase enzyme system
2000
Pritsos, C.A.
Chem. Biol. Interact.
129
195-208
Xanthine oxidase activity in mammalian cell cultures
1979
Clynes, M.M.; Hurley, M.P.; Shannon, M.F.
Biochem. Soc. Trans.
7
72-74
Purification and characterization of xanthine oxidase from livers of vitamin E deficient rabbits
1975
Catigani, G.L.; Chytil, F.; Darby, W.J.
Biochim. Biophys. Acta
377
34-41
-
Bovine, caprine, and human milk xanthine oxidases: isolation, purification, and characterization
1983
Zikakis, J.P.; Dressel, M.A.; Silver, M.R.
Instrum. Anal. Foods, Recent Prog. (Proc. Symp. Int. Flavor Conf. , 3rd Ed. , Charalambous, G. , Inglett, G. , eds. )
2
243-303
-
Cellular constituents. The chemistry of xanthine oxidase. Part I. The preparation of a crystalline xanthine oxidase from cow's milk
1955
Avis, P.G.; Bergel, F.; Bray, R.C.
J. Chem. Soc.
2
1100-1105
The role of molybdenum in xanthine oxidase and related enzymes. Reactivity with cyanide, arsenite, and methanol
1969
Coughlan, M.P.; Rajagopalan, K.V.; Handler, P.
J. Biol. Chem.
244
2658-2663
The regulation of rat liver xanthine oxidase: conversion of type D (dehydrogenase) into type O (oxidase) by a thermolabile factor, and reversibility by dithioerythritol
1970
Stirpe, F.; Della Corte, E.
Biochim. Biophys. Acta
212
195-197
characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrite reduction
2001
Li, H.; Samouilov, A.; Liu, X.; Zweier, J.L.
J. Biol. Chem.
276
24482-24489
-
Xanthine oxidase
1963
Bray, R.C.
The Enzymes, 2nd Ed. (Boyer, P. D. , Lardy, H. , Myrbäck, K. , eds. )
7
533-556
Milk xanthine oxidase type D (dehydrogenase) and type O (oxidase). Purification, interconversion and some properties
1973
Batelli, M.G.; Lorenzoni, E.; Stirpe, F.
Biochem. J.
131
191-198
-
Comparative aspects of xanthine-oxygen oxidoreductase systems
1973
Hayden, T.J.; Ryan, J.P.; Duke, E.J.
Biochem. Soc. Trans.
1
247-250
Chemistry and biochemistry of xanthine oxidase
1956
De Renzo, E.C.
Adv. Enzymol. Relat. Subj. Biochem.
17
293-328
-
Preparation of immobilized milk xanthine oxidase and application in organic synthesis
1987
Tramper, J.
Methods Enzymol.
136
254-262
A new purification procedure for bovine milk xanthine oxidase: effect of proteolysis on the subunit structure
1975
Waud, W.R.; Brady, F.O.; Wiley, R.D.; Rajagopalan, K.V.
Arch. Biochem. Biophys.
169
695-701
Extraction and purification of molybdenum cofactor from milk xanthine oxidase
1987
Van Spanning, R.J.M.; Wansell-Bettenhaussen, C.W.; Oltmann, L.F.; Stouthamer, A.H.
Eur. J. Biochem.
169
349-352
-
Purification properties and functional groups of bovine liver xanthine oxidase
1987
Cabre, F.; Canela, E.I.
Biochem. Soc. Trans.
15
511-512
Mechanism-based inactivation of mitochondrial monoamine oxidase by N-(1-methylcyclopropyl)benzylamine
1984
Morpeth, F.F.; Bray, R.C.
Biochemistry
23
1322-1338
Studies on the specificity toward aldehyde substrates and steady-state kinetics of xanthine oxidase
1983
Morpeth, F.F.
Biochim. Biophys. Acta
744
328-334
Association of xanthine oxidase with the bovine milk-fat-globule membrane. Nature of the enzyme-membrane association
1975
Briley, M.S.; Eisenthal, R.
Biochem. J.
147
417-423
Purification and characterization of mouse liver xanthine oxidase
1990
Carpani, G.; Racchi, M.; Ghezzi, P.; Terao, M.; Garattini, E.
Arch. Biochem. Biophys.
279
237-241
Ultrastructural localization of xanthine oxidoreductase activity in isolated rat liver cells
2002
Frederiks, W.M.; Vreeling-Sindelarova, H.
Acta Histochem.
104
29-37
Purification and partial characterisation of camel milk xanthine oxidoreductase
2003
Baghiani, A.; Harrison, R.; Benboubetra, M.
Arch. Physiol. Biochem.
111
407-414
Characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrate reduction: evaluation of its role in nitrite and nitric oxide generation in anoxic tissues
2003
Li, H.; Samouilov, A.; Liu, X.; Zweier, J.L.
Biochemistry
42
1150-1159
Cooperative catalysis in the homodimer subunits of xanthine oxidase
2004
Tai, L.A.; Hwang, K.C.
Biochemistry
43
4869-4876
Characterization of xanthine oxidase inhibition by anacardic acids
2004
Masuoka, N.; Kubo, I.
Biochim. Biophys. Acta
1688
245-249
Characterisation of methionine adenosyltransferase from Mycobacterium smegmatis and M. tuberculosis
2003
Berger, B.J.; Knodel, M.H.
BMC Microbiol.
3
12
Factors involved in the assembly of a functional molybdopyranopterin center in recombinant Comamonas acidovorans xanthine dehydrogenase
2003
Ivanov, N.V.; Hubalek, F.; Trani, M.; Edmondson, D.E.
Eur. J. Biochem.
270
4744-4754
Peroxynitrite formation from the simultaneous reduction of nitrite and oxygen by xanthine oxidase
2004
Millar, T.M.
FEBS Lett.
562
129-133
Recombinant Rhodobacter capsulatus xanthine dehydrogenase, a useful model system for the characterization of protein variants leading to xanthinuria I in humans
2003
Leimkuhler, S.; Hodson, R.; George, G.N.; Rajagopalan, K.V.
J. Biol. Chem.
278
20802-20811
Tandem orientation of duplicated xanthine dehydrogenase genes from Arabidopsis thaliana: differential gene expression and enzyme activities
2004
Hesberg, C.; Hansch, R.; Mendel, R.R.; Bittner, F.
J. Biol. Chem.
279
13547-13554
Characterization of the effects of oxygen on xanthine oxidase-mediated nitric oxide formation
2004
Li, H.; Samouilov, A.; Liu, X.; Zweier, J.L.
J. Biol. Chem.
279
16939-16946
The role of active site glutamate residues in catalysis of Rhodobacter capsulatus xanthine dehydrogenase
2004
Leimkuhler, S.; Stockert, A.L.; Igarashi, K.; Nishino, T.; Hille, R.
J. Biol. Chem.
279
40437-40444
Xanthine oxidase catalyzes anaerobic transformation of organic nitrates to nitric oxide and nitrosothiols: characterization of this mechanism and the link between organic nitrate and guanylyl cyclase activation
2005
Li, H.; Cui, H.; Liu, X.; Zweier, J.L.
J. Biol. Chem.
280
16594-16600
Physicochemical and kinetic properties of purified sheep's milk xanthine oxidoreductase
2004
Benboubetra, M.; Baghiani, A.; Atmani, D.; Harrison, R.
J. Dairy Sci.
87
1580-1584
Studies on the mechanism of action of xanthine oxidase
2004
Choi, E.Y.; Stockert, A.L.; Leimkuhler, S.; Hille, R.
J. Inorg. Biochem.
98
841-848
Subcellular localization of adenine and xanthine phosphoribosyltransferases in Leishmania donovani
2004
Zarella-Boitz, J.M.; Rager, N.; Jardim, A.; Ullman, B.
Mol. Biochem. Parasitol.
134
43-51
The plant Mo-hydroxylases aldehyde oxidase and xanthine dehydrogenase have distinct reactive oxygen species signatures and are induced by drought and abscisic acid
2005
Yesbergenova, Z.; Yang, G.; Oron, E.; Soffer, D.; Fluhr, R.; Sagi, M.
Plant J.
42
862-876
-
Xanthine dehydrogenase of pea seedlings: a member of the plant molybdenum oxidoreductase family
2002
Sauer, P.; Frebortova, J.; Sebela, M.; Galuszka, P.; Jacobsen, S.; Pec, P.; Frebort, I.
Plant Physiol. Biochem.
40
393-400
Inhibition of xanthine oxidase by phenolic conjugates of methylated quinic acid
2003
Gongora, L.; Manez, S.; Giner, R.M.; Recio, M.d.C.; Schinella, G.; Rios, J.L.
Planta Med.
69
396-401
A non-active site mutation in human hypoxanthine guanine phosphoribosyltransferase expands substrate specificity
2004
Raman, J.; Sumathy, K.; Anand, R.P.; Balaram, H.
Arch. Biochem. Biophys.
427
116-122
Plasmodium falciparum hypoxanthine guanine phosphoribosyltransferase. Stability studies on the product-activated enzyme
2005
Raman, J.; Ashok, C.S.; Subbayya, S.I.; Anand, R.P.; Selvi, S.T.; Balaram, H.
FEBS J.
272
1900-1911
Comprehensive study of bioanalytical platforms: xanthine oxidase
2006
Casero, E.; de Quesada, A.M.; Jin, J.; Quintana, M.C.; Pariente, F.; Abruna, H.D.; Vazquez, L.; Lorenzo, E.
Anal. Chem.
78
530-537
Characterization of an uricase from Bacillus fastidious A.T.C.C. 26904 and its application to serum uric acid assay by a patented kinetic uricase method
2006
Zhao, Y.; Zhao, L.; Yang, G.; Tao, J.; Bu, Y.; Liao, F.
Biotechnol. Appl. Biochem.
45
75-80
Identification of CFTR activators and inhibitors: chance or design?
2004
Galietta, L.J.; Moran, O.
Curr. Opin. Pharmacol.
4
497-503
Substrate specificity of guinea pig liver aldehyde oxidase and bovine milk xanthine oxidase for methyl- and nitrobenzaldehydes
2005
Veskoukis, A.S.; Kouretas, D.; Panoutsopoulos, G.I.
Eur. J. Drug Metab. Pharmacokinet.
31
11-16
Human Xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site: roles of active site residues in binding and activation of purine substrate
2007
Yamaguchi, Y.; Matsumura, T.; Ichida, K.; Okamoto, K.; Nishino, T.
J. Biochem.
141
513-524
Two mutations convert mammalian xanthine oxidoreductase to highly superoxide-productive xanthine oxidase
2007
Asai, R.; Nishino, T.; Matsumura, T.; Okamoto, K.; Igarashi, K.; Pai, E.F.; Nishino, T.
J. Biochem.
141
525-534
The role of arginine 310 in catalysis and substrate specificity in xanthine dehydrogenase from Rhodobacter capsulatus
2007
Pauff, J.M.; Hemann, C.F.; Juenemann, N.; Leimkuehler, S.; Hille, R.
J. Biol. Chem.
282
12785-12790
Application of HPLC to study the kinetics of a branched bi-enzyme system consisting of hypoxanthine-guanine phosphoribosyltransferase and xanthine oxidase - an important biochemical system to evaluate the efficiency of the anticancer drug 6-mercaptopurine
2007
Kalra, S.; Paul, M.K.; Balaram, H.; Mukhopadhyay, A.K.
J. Chromatogr. B
850
7-14
Purification of human malaria parasite hypoxanthine guanine xanthine phosphoribosyltransferase (HGXPRT) using immobilized Reactive Red 120
2007
Mbewe, B.; Chibale, K.; McIntosh, D.B.
Protein Expr. Purif.
52
153-158
Role of aspartate 143 in Escherichia coli tRNA-guanine transglycosylase: alteration of heterocyclic substrate specificity
2006
Todorov, K.A.; Garcia, G.A.
Biochemistry
45
617-625
The extraordinary specificity of xanthine phosphoribosyltransferase from Bacillus subtilis elucidated by reaction kinetics, ligand binding, and crystallography
2006
Arent, S.; Kadziola, A.; Larsen, S.; Neuhard, J.; Jensen, K.F.
Biochemistry
45
6615-6627
Role of extracellular superoxide in neutrophil activation: interactions between xanthine oxidase and TLR4 induce proinflammatory cytokine production
2008
Lorne, E.; Zmijewski, J.W.; Zhao, X.; Liu, G.; Tsuruta, Y.; Park, Y.J.; Dupont, H.; Abraham, E.
Am. J. Physiol.
294
C985-C993
In vivo reactive oxygen species production induced by ischemia in muscle arterioles of mice: involvement of xanthine oxidase and mitochondria
2008
Baudry, N.; Laemmel, E.; Vicaut, E.
Am. J. Physiol. Heart Circ. Physiol.
294
H821-H828
A comparison of reactive oxygen species metabolism in the rat aorta and vena cava: focus on xanthine oxidase
2008
Szasz, T.; Thompson, J.M.; Watts, S.W.
Am. J. Physiol. Heart Circ. Physiol.
295
H1341-H1350
Angiotensin II induces endothelial xanthine oxidase activation: role for endothelial dysfunction in patients with coronary disease
2007
Landmesser, U.; Spiekermann, S.; Preuss, C.; Sorrentino, S.; Fischer, D.; Manes, C.; Mueller, M.; Drexler, H.
Arterioscler. Thromb. Vasc. Biol.
27
943-948
Posttranslational ruling of xanthine oxidase activity in bovine milk by its substrates
2007
Silanikove, N.; Shapiro, F.; Leitner, G.
Biochem. Biophys. Res. Commun.
363
561-565
Structure-activity relationship of coumarin derivatives on xanthine oxidase-inhibiting and free radical-scavenging activities
2008
Lin, H.C.; Tsai, S.H.; Chen, C.S.; Chang, Y.C.; Lee, C.M.; Lai, Z.Y.; Lin, C.M.
Biochem. Pharmacol.
75
1416-1425
Nature and position of functional group on thiopurine substrates influence activity of xanthine oxidase - enzymatic reaction pathways of 6-mercaptopurine and 2-mercaptopurine are different
2007
Tamta, H.; Kalra, S.; Thilagavathi, R.; Chakraborti, A.K.; Mukhopadhyay, A.K.
Biochemistry (Moscow)
72
170-177
Biochemical and structural characterization of the hypoxanthine-guanine-xanthine phosphoribosyltransferase from Pyrococcus horikoshii
2008
de Souza Dantas, D.; Ramos Dos Santos, C.; Guimaraes Pereira, G.A.; Medrano, F.J.
Biochim. Biophys. Acta
1784
953-960
The screening and characterization of 6-aminopurine-based xanthine oxidase inhibitors
2007
Hsieh, J.F.; Wu, S.H.; Yang, Y.L.; Choong, K.F.; Chen, S.T.
Bioorg. Med. Chem.
15
3450-3456
Preferential inhibition of xanthine oxidase by 2-amino-6-hydroxy-8-mercaptopurine and 2-amino-6-purine thiol
2007
Kalra, S.; Jena, G.; Tikoo, K.; Mukhopadhyay, A.K.
BMC Biochem.
8
8
The role of urate and xanthine oxidase inhibitors in cardiovascular disease
2008
George, J.; Struthers, A.D.
Cardiovasc. Ther.
26
59-64
Lithospermic acid as a novel xanthine oxidase inhibitor has anti-inflammatory and hypouricemic effects in rats
2008
Liu, X.; Chen, R.; Shang, Y.; Jiao, B.; Huang, C.
Chem. Biol. Interact.
176
137-142
Existence of a new reactive intermediate oxygen species in hypoxanthine and xanthine oxidase reaction
2008
Sato, E.; Mokudai, T.; Niwano, Y.; Kamibayashi, M.; Kohno, M.
Chem. Pharm. Bull.
56
1194-1197
Laminar xanthine oxidase, superoxide dismutase and catalase activities in the prodromal stage of black-walnut induced equine laminitis
2007
Loftus, J.P.; Belknap, J.K.; Stankiewicz, K.M.; Black, S.J.
Equine Vet. J.
39
48-53
Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors
2008
Reigan, P.; Gbaj, A.; Stratford, I.J.; Bryce, R.A.; Freeman, S.
Eur. J. Med. Chem.
43
1248-1260
Synthesis of N-aryl-5-amino-4-cyanopyrazole derivatives as potent xanthine oxidase inhibitors
2008
Gupta, S.; Rodrigues, L.M.; Esteves, A.P.; Oliveira-Campos, A.M.; Nascimento, M.S.; Nazareth, N.; Cidade, H.; Neves, M.P.; Fernandes, E.; Pinto, M.; Cerqueira, N.M.; Bras, N.
Eur. J. Med. Chem.
43
771-780
Treatment with the xanthine oxidase inhibitor, allopurinol, improves nerve and vascular function in diabetic rats
2007
Inkster, M.E.; Cotter, M.A.; Cameron, N.E.
Eur. J. Pharmacol.
561
63-71
Structure-activity relationship of C6-C3 phenylpropanoids on xanthine oxidase-inhibiting and free radical-scavenging activities
2007
Chang, Y.C.; Lee, F.W.; Chen, C.S.; Huang, S.T.; Tsai, S.H.; Huang, S.H.; Lin, C.M.
Free Radic. Biol. Med.
43
1541-1551
Reactive oxygen species produced by NADPH oxidase, xanthine oxidase, and mitochondrial electron transport system mediate heat shock-induced MMP-1 and MMP-9 expression
2008
Shin, M.H.; Moon, Y.J.; Seo, J.E.; Lee, Y.; Kim, K.H.; Chung, J.H.
Free Radic. Biol. Med.
44
635-645
Age-related increase in xanthine oxidase activity in human plasma and rat tissues
2007
Aranda, R.; Domenech, E.; Rus, A.D.; Real, J.T.; Sastre, J.; Vina, J.; Pallardo, F.V.
Free Radic. Res.
41
1195-1200
Antioxidant activity of minimally processed red chicory (Cichorium intybus L.) evaluated in xanthine oxidase-, myeloperoxidase-, and diaphorase-catalyzed reactions
2008
Lavelli, V.
J. Agric. Food Chem.
56
7194-7200
Substrate orientation in xanthine oxidase: crystal structure of enzyme in reaction with 2-hydroxy-6-methylpurine
2008
Pauff, J.M.; Zhang, J.; Bell, C.E.; Hille, R.
J. Biol. Chem.
283
4818-4824
Xanthine oxidase inhibition improves left ventricular dysfunction in dilated cardiomyopathic hamsters
2008
Hayashi, K.; Kimata, H.; Obata, K.; Matsushita, A.; Fukata, A.; Hashimoto, K.; Noda, A.; Iwase, M.; Koike, Y.; Yokota, M.; Nagata, K.
J. Card. Fail.
14
238-244
The effect of age and gender on pharmacokinetics, pharmacodynamics, and safety of febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase
2008
Khosravan, R.; Kukulka, M.J.; Wu, J.T.; Joseph-Ridge, N.; Vernillet, L.
J. Clin. Pharmacol.
48
1014-1024
Microbial and xanthine dehydrogenase inhibitory activity of some flavones
2008
Khobragade, C.N.; Bodade, R.G.; Shinde, M.S.; Jaju, D.R.; Bhosle, R.B.; Dawane, B.S.
J. Enzyme Inhib. Med. Chem.
23
341-346
Renierol from marine sponge Haliclona sp.: a natural inhibitor of xanthine oxidase with hypouricemic effects
2008
Wang, G.F.; Shang, Y.J.; Jiao, B.H.; Huang, C.G.
J. Enzyme Inhib. Med. Chem.
23
406-410
Superoxide radicals scavenging and xanthine oxidase inhibitory activity of magnesium lithospermate B from Salvia miltiorrhiza
2008
Liu, X.; Chen, R.; Shang, Y.; Jiao, B.; Huang, C.
J. Enzyme Inhib. Med. Chem.
24
663-668
Xanthine oxidase-derived extracellular superoxide anions stimulate activator protein 1 activity and hypertrophy in human vascular smooth muscle via c-Jun N-terminal kinase and p38 mitogen-activated protein kinases
2007
Matesanz, N.; Lafuente, N.; Azcutia, V.; Martin, D.; Cuadrado, A.; Nevado, J.; Rodriguez-Manas, L.; Sanchez-Ferrer, C.F.; Peiro, C.
J. Hypertens.
25
609-618
Phosphatidylinositol 3-kinase and xanthine oxidase regulate nitric oxide and reactive oxygen species productions by apoptotic lymphocyte microparticles in endothelial cells
2008
Mostefai, H.A.; Agouni, A.; Carusio, N.; Mastronardi, M.L.; Heymes, C.; Henrion, D.; Andriantsitohaina, R.; Martinez, M.C.
J. Immunol.
180
5028-5035
Chronic xanthine oxidase inhibition following myocardial infarction in rabbits: effects of early versus delayed treatment
2008
Zhao, L.; Roche, B.M.; Wessale, J.L.; Kijtawornrat, A.; Lolly, J.L.; Shemanski, D.; Hamlin, R.L.
Life Sci.
82
495-502
Treatment with the xanthine oxidase inhibitor febuxostat lowers uric acid and alleviates systemic and glomerular hypertension in experimental hyperuricaemia
2008
Sanchez-Lozada, L.G.; Tapia, E.; Soto, V.; Avila-Casado, C.; Franco, M.; Zhao, L.; Johnson, R.J.
Nephrol. Dial. Transplant.
23
1179-1185
Kynurenic acid inhibits intestinal hypermotility and xanthine oxidase activity during experimental colon obstruction in dogs
2008
Kaszaki, J.; Palasthy, Z.; Erczes, D.; Racz, A.; Torday, C.; Varga, G.; Vecsei, L.; Boros, M.
Neurogastroenterol. Motil.
20
53-62
Mechanism of transition from xanthine dehydrogenase to xanthine oxidase: Effect of guanidine-HCl or urea on the activity
2008
Tsujii, A.; Nishino, T.
Nucleosides Nucleotides Nucleic Acids
27
881-887
Functional characterization of human xanthine oxidase allelic variants
2008
Kudo, M.; Moteki, T.; Sasaki, T.; Konno, Y.; Ujiie, S.; Onose, A.; Mizugaki, M.; Ishikawa, M.; Hiratsuka, M.
Pharmacogenet. Genomics
18
243-251
Molecular cloning, characterization and regulation of two different NADH-glutamate synthase cDNAs in bean nodules
2008
Blanco, L.; Reddy, P.M.; Silvente, S.; Bucciarelli, B.; Khandual, S.; Alvarado-Affantranger, X.; Sanchez, F.; Miller, S.; Vance, C.; Lara-Flores, M.
Plant Cell Environ.
31
454-472
The dual actions of Paederia scandens extract as a hypouricemic agent: xanthine oxidase inhibitory activity and uricosuric effect
2008
Yan, H.; Ma, Y.; Liu, M.; Zhou, L.
Planta Med.
74
1345-1350
Single exposure gamma-irradiation amplifies xanthine oxidase activity and induces endothelial dysfunction in rat aorta
2007
Soucy, K.G.; Lim, H.K.; Benjo, A.; Santhanam, L.; Ryoo, S.; Shoukas, A.A.; Vazquez, M.E.; Berkowitz, D.E.
Radiat. Environ. Biophys.
46
179-186
The potential role for xanthine oxidase inhibition in major intra-abdominal surgery
2008
Mittal, A.; Phillips, A.R.; Loveday, B.; Windsor, J.A.
World J. Surg.
32
288-295
In vitro drug-drug interaction studies with febuxostat, a novel non-purine selective inhibitor of xanthine oxidase: plasma protein binding, identification of metabolic enzymes and cytochrome P450 inhibition
2008
Mukoyoshi, M.; Nishimura, S.; Hoshide, S.; Umeda, S.; Kanou, M.; Taniguchi, K.; Muroga, H.
Xenobiotica
38
496-510
Inhibitory effects of flavonoids on aldehyde oxidase activity
2009
Pirouzpanah, S.; Hanaee, J.; Razavieh, S.V.; Rashidi, M.R.
J. Enzyme Inhib. Med. Chem.
24
14-21
Functional and structural alterations induced by copper in xanthine oxidase
2009
Hadizadeh, M.; Keyhani, E.; Keyhani, J.; Khodadadi, C.
Acta Biochim. Biophys. Sin.
41
603-617
Catalytic activity and stability of xanthine oxidase in aqueous-organic mixtures
2009
Rashidi, M.R.; Soruraddin, M.H.; Taherzadeh, F.; Jouyban, A.
Biochemistry (Moscow)
74
97-101
Inhibition of CTP synthase from Escherichia coli by xanthines and uric acids
2010
Roy, A.C.; Lunn, F.A.; Bearne, S.L.
Bioorg. Med. Chem. Lett.
20
141-144
Brain purine metabolism and xanthine dehydrogenase/oxidase conversion in hyperammonemia are under control of NMDA receptors and nitric oxide
2009
Kaminsky, Y.; Kosenko, C.I.e.
Brain Res.
1294
193-201
Effects of allopurinol on uric acid concentrations, xanthine oxidoreductase activity and oxidative stress in broiler chickens
2009
Carro, M.D.; Falkenstein, E.; Radke, W.J.; Klandorf, H.
Comp. Biochem. Physiol. C
151
12-17
Mammalian xanthine oxidoreductase - mechanism of transition from xanthine dehydrogenase to xanthine oxidase
2008
Nishino, T.; Okamoto, K.; Eger, B.T.; Pai, E.F.; Nishino, T.
FEBS J.
275
3278-3289
Acidic residues in the purine binding site govern the 6-oxopurine specificity of the Leishmania donovani xanthine phosphoribosyltransferase
2010
Ullman, B.; Cyr, N.; Choi, K.; Jardim, A.
Int. J. Biochem. Cell Biol.
42
253-262
The mechanism of assembly and cofactor insertion into Rhodobacter capsulatus xanthine dehydrogenase
2008
Schumann, S.; Saggu, M.; Moeller, N.; Anker, S.D.; Lendzian, F.; Hildebrandt, P.; Leimkuehler, S.
J. Biol. Chem.
283
16602-16611
Nitro-oleic acid, a novel and irreversible inhibitor of xanthine oxidoreductase
2008
Kelley, E.E.; Batthyany, C.I.; Hundley, N.J.; Woodcock, S.R.; Bonacci, G.; Del Rio, J.M.; Schopfer, F.J.; Lancaster, J.R.; Freeman, B.A.; Tarpey, M.M.
J. Biol. Chem.
283
36176-36184
Mechanism of substrate and inhibitor binding of Rhodobacter capsulatus xanthine dehydrogenase
2009
Dietzel, U.; Kuper, J.; Doebbler, J.A.; Schulte, A.; Truglio, J.J.; Leimkuehler, S.; Kisker, C.
J. Biol. Chem.
284
8768-8776
-
Indonesian Sidaguri (Sida rhombifolia L.) as antigout and inhibition kinetics of flavonoids crude extract on the activity of xanthine oxidase
2009
Iswantini, D.; Darusman, L.; Hidayat, R.
J. Biol. Sci.
9
504-508
Orange juice and hesperetin supplementation to hyperuricemic rats alter oxidative stress markers and xanthine oxidoreductase activity
2009
Haidari, F.; Ali Keshavarz, S.; Reza Rashidi, M.; Mohammad Shahi, M.
J. Clin. Biochem. Nutr.
45
285-291
Xanthine dehydrogenase processes retinol to retinoic acid in human mammary epithelial cells
2008
Taibi, G.; Di Gaudio, F.; Nicotra, C.M.
J. Enzyme Inhib. Med. Chem.
23
317-327
Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics
2009
Keough, D.T.; Hockova, D.; Holy, A.; Naesens, L.M.; Skinner-Adams, T.S.; Jersey, J.; Guddat, L.W.
J. Med. Chem.
52
4391-4399
Hydroxychavicol: a potent xanthine oxidase inhibitor obtained from the leaves of betel, Piper betle
2009
Murata, K.; Nakao, K.; Hirata, N.; Namba, K.; Nomi, T.; Kitamura, Y.; Moriyama, K.; Shintani, T.; Iinuma, M.; Matsuda, H.
J. Nat. Med.
63
355-359
Inhibition studies of bovine xanthine oxidase by luteolin, silibinin, quercetin, and curcumin
2009
Pauff, J.M.; Hille, R.
J. Nat. Prod.
72
725-731
On-chip assay for determining the inhibitory effects and modes of action of drugs against xanthine oxidase
2010
Naoghare, P.K.; Kwon, H.T.; Song, J.M.
J. Pharm. Biomed. Anal.
51
1-6
Effects of onion on serum uric acid levels and hepatic xanthine dehydrogenase/xanthine oxidase activities in hyperuricemic rats
2008
Haidari, F.; Rashidi, M.R.; Keshavarz, S.A.; Mahboob, S.A.; Eshraghian, M.R.; Shahi, M.M.
Pak. J. Biol. Sci.
11
1779-1784
Xanthine dehydrogenase AtXDH1 from Arabidopsis thaliana is a potent producer of superoxide anions via its NADH oxidase activity
2009
Zarepour, M.; Kaspari, K.; Stagge, S.; Rethmeier, R.; Mendel, R.R.; Bittner, F.
Plant Mol. Biol.
72
301-310
Lonicera hypoglauca inhibits xanthine oxidase and reduces serum uric acid in mice
2009
Chien, S.C.; Yang, C.W.; Tseng, Y.H.; Tsay, H.S.; Kuo, Y.H.; Wang, S.Y.
Planta Med.
75
302-306
Crystal structure of a chimera of human and Plasmodium falciparum hypoxanthine guanine phosphoribosyltransferases provides insights into oligomerization
2008
Gayathri, P.; Sujay Subbayya, I.; Ashok, C.; Senthamizh Selvi, T.; Balaram, H.; Murthy, M.
Proteins
73
1010-1020
FYX-051, a xanthine oxidoreductase inhibitor, induces nephropathy in rats, but not in monkeys
2009
Shimo, T.; Ashizawa, N.; Moto, M.; Matsumoto, K.; Iwanaga, T.; Nagata, O.
Toxicol. Pathol.
37
438-445
Identification of small molecule compounds with higher binding affinity to guanine deaminase (cypin) than guanine
2010
Fernandez, J.R.; Sweet, E.S.; Welsh, W.J.; Firestein, B.L.
Bioorg. Med. Chem.
18
6748-6755
Effects of modification of amino groups with poly(ethylene glycol) on a recombinant uricase from Bacillus fastidiosus
2010
Zhang, C.; Yang, X.; Feng, J.; Yuan, Y.; Li, X.; Bu, Y.; Xie, Y.; Yuan, H.; Liao, F.
Biosci. Biotechnol. Biochem.
74
1298-1301
Synthesis and xanthine oxidase inhibitory activity of 7-methyl-2-(phenoxymethyl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one derivatives
2011
Sathisha, K.R.; Khanum, S.A.; Chandra, J.N.; Ayisha, F.; Balaji, S.; Marathe, G.K.; Gopal, S.; Rangappa, K.S.
Bioorg. Med. Chem.
19
211-220
-
Activity and stability of rat liver xanthine oxidase in the presence of pyridine
2011
Amini, K.; Sorouraddin, M.; Rashidi, M.
Can. J. Chem.
89
1-7
Regulation of xanthine oxidase activity by substrates at active sites via cooperative interactions between catalytic subunits: implication to drug pharmacokinetics
2011
Tai, L.A.; Hwang, K.C.
Curr. Med. Chem.
18
69-78
Effects of genistein, apigenin, quercetin, rutin and astilbin on serum uric acid levels and xanthine oxidase activities in normal and hyperuricemic mice
2011
Huang, J.; Wang, S.; Zhu, M.; Chen, J.; Zhu, X.
Food Chem. Toxicol.
49
1943-1947
The structure of formaldehyde-inhibited xanthine oxidase determined by 35 GHz 2H ENDOR spectroscopy
2010
Shanmugam, M.; Zhang, B.; McNaughton, R.L.; Kinney, R.A.; Hille, R.; Hoffman, B.M.
J. Am. Chem. Soc.
132
14015-14017
Crystal structures of urate bound form of xanthine oxidoreductase: Substrate orientation and structure of the key reaction intermediate
2010
Okamoto, K.; Kawaguchi, Y.; Eger, B.; Pai, E.; Nishino, T.
J. Am. Chem. Soc.
132
17080-17083
Substrate orientation and catalytic specificity in the action of xanthine oxidase: the sequential hydroxylation of hypoxanthine to uric acid
2010
Cao, H.; Pauff, J.M.; Hille, R.
J. Biol. Chem.
285
28044-28053
Inhibition of xanthine oxidase activity results in the inhibition of Russian wheat aphid-induced defense enzymes
2010
Berner, J.M.; Van der Westhuizen, A.J.
J. Chem. Ecol.
36
1375-1380
QM/MM studies of xanthine oxidase: variations of cofactor, substrate, and active-site Glu802
2010
Metz, S.; Thiel, W.
J. Phys. Chem. B
114
1506-1517
Down-regulation of hepatic urea synthesis by oxypurines: xanthine and uric acid inhibit N-acetylglutamate synthase
2011
Nissim, I.; Horyn, O.; Nissim, I.; Daikhin, Y.; Caldovic, L.; Barcelona, B.; Cervera, J.; Tuchman, M.; Yudkoff, M.
J. Biol. Chem.
286
22055-22068
Hypoxanthine guanine phosphoribosyltransferase distorts the purine ring of nucleotide substrates and perturbs the pKa of bound xanthosine monophosphate
2011
Gogia, S.; Balaram, H.; Puranik, M.
Biochemistry
50
4184-4193
Acyclic immucillin phosphonates: second-generation inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase
2012
Hazleton, K.Z.; Ho, M.C.; Cassera, M.B.; Clinch, K.; Crump, D.R.; Rosario, I.; Merino, E.F.; Almo, S.C.; Tyler, P.C.; Schramm, V.L.
Chem. Biol.
19
721-730
Specificities and pH profiles of adenine and hypoxanthine-guanine-xanthine phosphoribosyltransferases (nucleotide synthases) of the thermoacidophile archaeon Sulfolobus solfataricus
2014
Hansen, M.R.; Jensen, K.S.; Rasmussen, M.S.; Christoffersen, S.; Kadziola, A.; Jensen, K.F.
Extremophiles
18
179-187
Identification and characterization of an antennae-specific aldehyde oxidase from the navel orangeworm
2013
Choo, Y.M.; Pelletier, J.; Atungulu, E.; Leal, W.S.
PLoS ONE
8
e67794
In vitro effect of novel beta-lactam compounds on xanthine oxidase enzyme activity
2012
Bytyqi-Damoni, A.; Genc, H.; Zengin, M.; Beyaztas, S.; Gencer, N.; Arslan, O.
Artif. Cells Blood Substit. Immobil. Biotechnol.
40
369-377
Arxula adeninivorans xanthine oxidoreductase and its application in the production of food with low purine content
2013
Jankowska, D.A.; Trautwein-Schult, A.; Cordes, A.; Hoferichter, P.; Klein, C.; Bode, R.; Baronian, K.; Kunze, G.
J. Appl. Microbiol.
115
796-807
Catalytic electrochemistry of xanthine dehydrogenase
2012
Kalimuthu, P.; Leimkuehler, S.; Bernhardt, P.V.
J. Phys. Chem. B
116
11600-11607
Mechanism of porcine liver xanthine oxidoreductase mediated N-oxide reduction of cyanoacetylhydrazone 2-formylquinoxaline-1,4-dioxide as revealed by docking and mutagenesis studies
2013
Chen, C.; Cheng, G.; Hao, H.; Dai, M.; Wang, X.; Huang, L.; Liu, Z.; Yuan, Z.
PLoS ONE
8
e73912
The effects of allopurinol, uric acid, and inosine administration on xanthine oxidoreductase activity and uric acid concentrations in broilers
2012
Settle, T.; Carro, M.D.; Falkenstein, E.; Radke, W.; Klandorf, H.
Poult. Sci.
91
2895-2903
-
Expression, purification and partial characterization of a xanthine oxidase (XOD) in Arthrobacter sp
2012
Xin, Y.; Yang, H.; Xia, X.; Zhang, L.; Zhang, Y.; Cheng, C.; Wang, W.
Process Biochem.
47
1539-1544
Characterization of active site variants of xanthine hydroxylase from Aspergillus nidulans
2008
Li, M.; Muller, T.A.; Fraser, B.A.; Hausinger, R.P.
Arch. Biochem. Biophys.
470
44-53
Purification and characterization of the FeII- and alpha-ketoglutarate-dependent xanthine hydroxylase from Aspergillus nidulans
2007
Montero-Moran, G.M.; Li, M.; Rendon-Huerta, E.; Jourdan, F.; Lowe, D.J.; Stumpff-Kane, A.W.; Feig, M.; Scazzocchio, C.; Hausinger, R.P.
Biochemistry
46
5293-5304
Convergent evolution of hydroxylation mechanisms in the fungal kingdom: molybdenum cofactor-independent hydroxylation of xanthine via alpha-ketoglutarate-dependent dioxygenases
2005
Cultrone, A.; Scazzocchio, C.; Rochet, M.; Montero-Moran, G.; Drevet, C.; Fernandez-Martin, R.
Mol. Microbiol.
57
276-290
Arxula adeninivorans recombinant guanine deaminase and its application in the production of food with low purine content
2014
Trautwein-Schult, A.; Jankowska, D.; Cordes, A.; Hoferichter, P.; Klein, C.; Matros, A.; Mock, H.P.; Baronian, K.; Bode, R.; Kunze, G.
J. Mol. Microbiol. Biotechnol.
24
67-81
Acyclic phosph(on)ate inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase
2013
Clinch, K.; Crump, D.R.; Evans, G.B.; Hazleton, K.Z.; Mason, J.M.; Schramm, V.L.; Tyler, P.C.
Bioorg. Med. Chem.
21
5629-5646
Kinetic mechanism of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase
2015
Roy, S.; Nagappa, L.K.; Prahladarao, V.S.; Balaram, H.
Mol. Biochem. Parasitol.
204
111-120
Slow ligand-induced conformational switch increases the catalytic rate in Plasmodium falciparum hypoxanthine guanine xanthine phosphoribosyltransferase
2015
Roy, S.; Karmakar, T.; Prahlada Rao, V.S.; Nagappa, L.K.; Balasubramanian, S.; Balaram, H.
Mol. Biosyst.
11
1410-1424
-
Enhanced catalytic properties of novel (alphabetagamma)2 heterohexameric Rhodobacter capsulatus xanthine dehydrogenase by separate expression of the redox domains in Escherichia coli
2017
Wang, C.; Li, G.; Zhang, C.; Xing, X.
Biochem. Eng. J.
119
1-8
Xanthine dehydrogenase an old enzyme with new knowledge and prospects
2016
Wang, C.H.; Zhang, C.; Xing, X.H.
Bioengineered
7
395-405
Xanthine oxidase inhibitory activity of nicotino/isonicotinohydrazides a systematic approach from in vitro, in silico to in vivo studies
2017
Zafar, H.; Hayat, M.; Saied, S.; Khan, M.; Salar, U.; Malik, R.; Choudhary, M.I.; Khan, K.M.
Bioorg. Med. Chem.
25
2351-2371
Enhancing xanthine oxidase fermentation with pH-shift strategy based on kinetic analysis by Arthrobacter M3
2014
Zhang, Y.; Yang, H.; Xin, Y.; Zhang, L.; Wang, W.
Bioprocess Biosyst. Eng.
37
1899-1905
Metabolic engineering of Escherichia coli cell factory for highly active xanthine dehydrogenase production
2017
Wang, C.H.; Zhang, C.; Xing, X.H.
Biores. Technol.
245
1782-1789
Purine nucleoside phosphorylase and xanthine oxidase activities in erythrocytes and plasma from marine, semiaquatic and terrestrial mammals
2014
Lopez-Cruz, R.I.; Perez-Milicua, M.B.; Crocker, D.E.; Gaxiola-Robles, R.; Bernal-Vertiz, J.A.; de la Rosa, A.; Vazquez-Medina, J.P.; Zenteno-Savin, T.
Comp. Biochem. Physiol. A
171
31-35
Synthesis and evaluation of xanthine oxidase inhibitory and antioxidant activities of 2-arylbenzo[b]furan derivatives based on salvianolic acid C
2016
Tang, H.J.; Zhang, X.W.; Yang, L.; Li, W.; Li, J.H.; Wang, J.X.; Chen, J.
Eur. J. Med. Chem.
124
637-648
The C-terminal peptide plays a role in the formation of an intermediate form during the transition between xanthine dehydrogenase and xanthine oxidase
2015
Nishino, T.; Okamoto, K.; Kawaguchi, Y.; Matsumura, T.; Eger, B.T.; Pai, E.F.; Nishino, T.
FEBS J.
282
3075-3090
Thermostable xanthine oxidase activity from Bacillus pumilus RL-2d isolated from Manikaran thermal spring production and characterization
2016
Sharma, N.K.; Thakur, S.; Thakur, N.; Savitri, N.; Bhalla, T.C.
Indian J. Microbiol.
56
88-98
Protonation and sulfido versus oxo ligation changes at the molybdenum cofactor in xanthine dehydrogenase (XDH) variants studied by X-ray absorption spectroscopy
2017
Reschke, S.; Mebs, S.; Sigfridsson-Clauss, K.G.; Kositzki, R.; Leimkuehler, S.; Haumann, M.
Inorg. Chem.
56
2165-2176
Flavonols and flavan-3-ols as modulators of xanthine oxidase and manganese superoxide dismutase activity
2014
Di Majo, D.; La Guardia, M.; Leto, G.; Crescimanno, M.; Flandina, C.; Giammanco, M.
Int. J. Food Sci. Nutr.
65
886-892
The reductive half-reaction of xanthine dehydrogenase from Rhodobacter capsulatus the role of Glu232 in catalysis
2014
Hall, J.; Reschke, S.; Cao, H.; Leimkuehler, S.; Hille, R.
J. Biol. Chem.
289
32121-32130
Kinetic study on the inhibition of xanthine oxidase by acylated derivatives of flavonoids synthesised enzymatically
2017
de Araujo, M.E.M.B.; Franco, Y.E.M.; Alberto, T.G.; Messias, M.C.F.; Leme, C.W.; Sawaya, A.C.H.F.; Carvalho, P.O.
J. Enzyme Inhib. Med. Chem.
32
978-985
Serum adenosine deaminase and xanthine oxidase activities in silver catfish naturally infected with Ichthyophthirius multifiliis The influence of these enzymes on inflammatory and oxidative status
2018
Baldissera, M.D.; Souza, C.F.; Doleski, P.H.; Monteiro, S.G.; da Silva, A.S.; Baldisserotto, B.
J. Fish Dis.
41
263-268
X-ray crystal structure of a xanthine oxidase complex with the flavonoid inhibitor quercetin
2014
Cao, H.; Pauff, J.M.; Hille, R.
J. Nat. Prod.
77
1693-1699
Xanthine oxidase activity affects pro-oxidative and pro-inflammatory profiles in spleen of silver catfish experimentally infected with Aeromonas caviae
2017
Souza, C.F.; Verdi, C.M.; Baldissera, M.D.; Doleski, P.H.; Vizzotto, B.S.; Santos, R.C.V.; Baldisserotto, B.
Microb. Pathog.
113
25-28
-
Arabidopsis xanthine dehydrogenase mutants defective in purine degradation show a compromised protective response to drought and oxidative stress
2014
Watanabe, S.; Kounosu, Y.; Shimada, H.; Sakamoto, A.
Plant Biotechnol.
31
173-178
-
A Vitis vinifera xanthine dehydrogenase gene, VvXDH, enhances salinity tolerance in transgenic Arabidopsis
2017
You, S.; Zhu, B.; Wang, F.; Han, H.; Sun, M.; Zhu, H.; Peng, R.; Yao, Q.
Plant Biotechnol. Rep.
11
147-160
Opposing functions for plant xanthine dehydrogenase in response to powdery mildew infection production and scavenging of reactive oxygen species
2016
Hofmann, N.
Plant Cell
28
1001
Dual and opposing roles of xanthine dehydrogenase in defense-associated reactive oxygen species metabolism in Arabidopsis
2016
Ma, X.; Wang, W.; Bittner, F.; Schmidt, N.; Berkey, R.; Zhang, L.; King, H.; Zhang, Y.; Feng, J.; Wen, Y.; Tan, L.; Li, Y.; Zhang, Q.; Deng, Z.; Xiong, X.; Xiao, S.
Plant Cell
28
1108-1126
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