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J. Biol. Chem.
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Nitro-oleic acid, a novel and irreversible inhibitor of xanthine oxidoreductase
2008
Kelley, E.E.; Batthyany, C.I.; Hundley, N.J.; Woodcock, S.R.; Bonacci, G.; Del Rio, J.M.; Schopfer, F.J.; Lancaster, J.R.; Freeman, B.A.; Tarpey, M.M.
J. Biol. Chem.
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Mechanism of substrate and inhibitor binding of Rhodobacter capsulatus xanthine dehydrogenase
2009
Dietzel, U.; Kuper, J.; Doebbler, J.A.; Schulte, A.; Truglio, J.J.; Leimkuehler, S.; Kisker, C.
J. Biol. Chem.
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Indonesian Sidaguri (Sida rhombifolia L.) as antigout and inhibition kinetics of flavonoids crude extract on the activity of xanthine oxidase
2009
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J. Biol. Sci.
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Orange juice and hesperetin supplementation to hyperuricemic rats alter oxidative stress markers and xanthine oxidoreductase activity
2009
Haidari, F.; Ali Keshavarz, S.; Reza Rashidi, M.; Mohammad Shahi, M.
J. Clin. Biochem. Nutr.
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Xanthine dehydrogenase processes retinol to retinoic acid in human mammary epithelial cells
2008
Taibi, G.; Di Gaudio, F.; Nicotra, C.M.
J. Enzyme Inhib. Med. Chem.
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Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics
2009
Keough, D.T.; Hockova, D.; Holy, A.; Naesens, L.M.; Skinner-Adams, T.S.; Jersey, J.; Guddat, L.W.
J. Med. Chem.
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Hydroxychavicol: a potent xanthine oxidase inhibitor obtained from the leaves of betel, Piper betle
2009
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J. Nat. Med.
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Inhibition studies of bovine xanthine oxidase by luteolin, silibinin, quercetin, and curcumin
2009
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J. Nat. Prod.
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On-chip assay for determining the inhibitory effects and modes of action of drugs against xanthine oxidase
2010
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J. Pharm. Biomed. Anal.
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Effects of onion on serum uric acid levels and hepatic xanthine dehydrogenase/xanthine oxidase activities in hyperuricemic rats
2008
Haidari, F.; Rashidi, M.R.; Keshavarz, S.A.; Mahboob, S.A.; Eshraghian, M.R.; Shahi, M.M.
Pak. J. Biol. Sci.
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Xanthine dehydrogenase AtXDH1 from Arabidopsis thaliana is a potent producer of superoxide anions via its NADH oxidase activity
2009
Zarepour, M.; Kaspari, K.; Stagge, S.; Rethmeier, R.; Mendel, R.R.; Bittner, F.
Plant Mol. Biol.
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Lonicera hypoglauca inhibits xanthine oxidase and reduces serum uric acid in mice
2009
Chien, S.C.; Yang, C.W.; Tseng, Y.H.; Tsay, H.S.; Kuo, Y.H.; Wang, S.Y.
Planta Med.
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Crystal structure of a chimera of human and Plasmodium falciparum hypoxanthine guanine phosphoribosyltransferases provides insights into oligomerization
2008
Gayathri, P.; Sujay Subbayya, I.; Ashok, C.; Senthamizh Selvi, T.; Balaram, H.; Murthy, M.
Proteins
73
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FYX-051, a xanthine oxidoreductase inhibitor, induces nephropathy in rats, but not in monkeys
2009
Shimo, T.; Ashizawa, N.; Moto, M.; Matsumoto, K.; Iwanaga, T.; Nagata, O.
Toxicol. Pathol.
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Identification of small molecule compounds with higher binding affinity to guanine deaminase (cypin) than guanine
2010
Fernandez, J.R.; Sweet, E.S.; Welsh, W.J.; Firestein, B.L.
Bioorg. Med. Chem.
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Effects of modification of amino groups with poly(ethylene glycol) on a recombinant uricase from Bacillus fastidiosus
2010
Zhang, C.; Yang, X.; Feng, J.; Yuan, Y.; Li, X.; Bu, Y.; Xie, Y.; Yuan, H.; Liao, F.
Biosci. Biotechnol. Biochem.
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Synthesis and xanthine oxidase inhibitory activity of 7-methyl-2-(phenoxymethyl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one derivatives
2011
Sathisha, K.R.; Khanum, S.A.; Chandra, J.N.; Ayisha, F.; Balaji, S.; Marathe, G.K.; Gopal, S.; Rangappa, K.S.
Bioorg. Med. Chem.
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Activity and stability of rat liver xanthine oxidase in the presence of pyridine
2011
Amini, K.; Sorouraddin, M.; Rashidi, M.
Can. J. Chem.
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Regulation of xanthine oxidase activity by substrates at active sites via cooperative interactions between catalytic subunits: implication to drug pharmacokinetics
2011
Tai, L.A.; Hwang, K.C.
Curr. Med. Chem.
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Effects of genistein, apigenin, quercetin, rutin and astilbin on serum uric acid levels and xanthine oxidase activities in normal and hyperuricemic mice
2011
Huang, J.; Wang, S.; Zhu, M.; Chen, J.; Zhu, X.
Food Chem. Toxicol.
49
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The structure of formaldehyde-inhibited xanthine oxidase determined by 35 GHz 2H ENDOR spectroscopy
2010
Shanmugam, M.; Zhang, B.; McNaughton, R.L.; Kinney, R.A.; Hille, R.; Hoffman, B.M.
J. Am. Chem. Soc.
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Crystal structures of urate bound form of xanthine oxidoreductase: Substrate orientation and structure of the key reaction intermediate
2010
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J. Am. Chem. Soc.
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Substrate orientation and catalytic specificity in the action of xanthine oxidase: the sequential hydroxylation of hypoxanthine to uric acid
2010
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J. Biol. Chem.
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Inhibition of xanthine oxidase activity results in the inhibition of Russian wheat aphid-induced defense enzymes
2010
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J. Chem. Ecol.
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QM/MM studies of xanthine oxidase: variations of cofactor, substrate, and active-site Glu802
2010
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J. Phys. Chem. B
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Down-regulation of hepatic urea synthesis by oxypurines: xanthine and uric acid inhibit N-acetylglutamate synthase
2011
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Hypoxanthine guanine phosphoribosyltransferase distorts the purine ring of nucleotide substrates and perturbs the pKa of bound xanthosine monophosphate
2011
Gogia, S.; Balaram, H.; Puranik, M.
Biochemistry
50
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Acyclic immucillin phosphonates: second-generation inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase
2012
Hazleton, K.Z.; Ho, M.C.; Cassera, M.B.; Clinch, K.; Crump, D.R.; Rosario, I.; Merino, E.F.; Almo, S.C.; Tyler, P.C.; Schramm, V.L.
Chem. Biol.
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Specificities and pH profiles of adenine and hypoxanthine-guanine-xanthine phosphoribosyltransferases (nucleotide synthases) of the thermoacidophile archaeon Sulfolobus solfataricus
2014
Hansen, M.R.; Jensen, K.S.; Rasmussen, M.S.; Christoffersen, S.; Kadziola, A.; Jensen, K.F.
Extremophiles
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Identification and characterization of an antennae-specific aldehyde oxidase from the navel orangeworm
2013
Choo, Y.M.; Pelletier, J.; Atungulu, E.; Leal, W.S.
PLoS ONE
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In vitro effect of novel beta-lactam compounds on xanthine oxidase enzyme activity
2012
Bytyqi-Damoni, A.; Genc, H.; Zengin, M.; Beyaztas, S.; Gencer, N.; Arslan, O.
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Arxula adeninivorans xanthine oxidoreductase and its application in the production of food with low purine content
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Catalytic electrochemistry of xanthine dehydrogenase
2012
Kalimuthu, P.; Leimkuehler, S.; Bernhardt, P.V.
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Mechanism of porcine liver xanthine oxidoreductase mediated N-oxide reduction of cyanoacetylhydrazone 2-formylquinoxaline-1,4-dioxide as revealed by docking and mutagenesis studies
2013
Chen, C.; Cheng, G.; Hao, H.; Dai, M.; Wang, X.; Huang, L.; Liu, Z.; Yuan, Z.
PLoS ONE
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The effects of allopurinol, uric acid, and inosine administration on xanthine oxidoreductase activity and uric acid concentrations in broilers
2012
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Expression, purification and partial characterization of a xanthine oxidase (XOD) in Arthrobacter sp
2012
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Process Biochem.
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Characterization of active site variants of xanthine hydroxylase from Aspergillus nidulans
2008
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Arch. Biochem. Biophys.
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Purification and characterization of the FeII- and alpha-ketoglutarate-dependent xanthine hydroxylase from Aspergillus nidulans
2007
Montero-Moran, G.M.; Li, M.; Rendon-Huerta, E.; Jourdan, F.; Lowe, D.J.; Stumpff-Kane, A.W.; Feig, M.; Scazzocchio, C.; Hausinger, R.P.
Biochemistry
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Convergent evolution of hydroxylation mechanisms in the fungal kingdom: molybdenum cofactor-independent hydroxylation of xanthine via alpha-ketoglutarate-dependent dioxygenases
2005
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Mol. Microbiol.
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Arxula adeninivorans recombinant guanine deaminase and its application in the production of food with low purine content
2014
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Acyclic phosph(on)ate inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase
2013
Clinch, K.; Crump, D.R.; Evans, G.B.; Hazleton, K.Z.; Mason, J.M.; Schramm, V.L.; Tyler, P.C.
Bioorg. Med. Chem.
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Kinetic mechanism of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase
2015
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Mol. Biochem. Parasitol.
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Slow ligand-induced conformational switch increases the catalytic rate in Plasmodium falciparum hypoxanthine guanine xanthine phosphoribosyltransferase
2015
Roy, S.; Karmakar, T.; Prahlada Rao, V.S.; Nagappa, L.K.; Balasubramanian, S.; Balaram, H.
Mol. Biosyst.
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Enhanced catalytic properties of novel (alphabetagamma)2 heterohexameric Rhodobacter capsulatus xanthine dehydrogenase by separate expression of the redox domains in Escherichia coli
2017
Wang, C.; Li, G.; Zhang, C.; Xing, X.
Biochem. Eng. J.
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Xanthine dehydrogenase an old enzyme with new knowledge and prospects
2016
Wang, C.H.; Zhang, C.; Xing, X.H.
Bioengineered
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Xanthine oxidase inhibitory activity of nicotino/isonicotinohydrazides a systematic approach from in vitro, in silico to in vivo studies
2017
Zafar, H.; Hayat, M.; Saied, S.; Khan, M.; Salar, U.; Malik, R.; Choudhary, M.I.; Khan, K.M.
Bioorg. Med. Chem.
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Enhancing xanthine oxidase fermentation with pH-shift strategy based on kinetic analysis by Arthrobacter M3
2014
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Bioprocess Biosyst. Eng.
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Metabolic engineering of Escherichia coli cell factory for highly active xanthine dehydrogenase production
2017
Wang, C.H.; Zhang, C.; Xing, X.H.
Biores. Technol.
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Purine nucleoside phosphorylase and xanthine oxidase activities in erythrocytes and plasma from marine, semiaquatic and terrestrial mammals
2014
Lopez-Cruz, R.I.; Perez-Milicua, M.B.; Crocker, D.E.; Gaxiola-Robles, R.; Bernal-Vertiz, J.A.; de la Rosa, A.; Vazquez-Medina, J.P.; Zenteno-Savin, T.
Comp. Biochem. Physiol. A
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Synthesis and evaluation of xanthine oxidase inhibitory and antioxidant activities of 2-arylbenzo[b]furan derivatives based on salvianolic acid C
2016
Tang, H.J.; Zhang, X.W.; Yang, L.; Li, W.; Li, J.H.; Wang, J.X.; Chen, J.
Eur. J. Med. Chem.
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The C-terminal peptide plays a role in the formation of an intermediate form during the transition between xanthine dehydrogenase and xanthine oxidase
2015
Nishino, T.; Okamoto, K.; Kawaguchi, Y.; Matsumura, T.; Eger, B.T.; Pai, E.F.; Nishino, T.
FEBS J.
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Thermostable xanthine oxidase activity from Bacillus pumilus RL-2d isolated from Manikaran thermal spring production and characterization
2016
Sharma, N.K.; Thakur, S.; Thakur, N.; Savitri, N.; Bhalla, T.C.
Indian J. Microbiol.
56
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Protonation and sulfido versus oxo ligation changes at the molybdenum cofactor in xanthine dehydrogenase (XDH) variants studied by X-ray absorption spectroscopy
2017
Reschke, S.; Mebs, S.; Sigfridsson-Clauss, K.G.; Kositzki, R.; Leimkuehler, S.; Haumann, M.
Inorg. Chem.
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Flavonols and flavan-3-ols as modulators of xanthine oxidase and manganese superoxide dismutase activity
2014
Di Majo, D.; La Guardia, M.; Leto, G.; Crescimanno, M.; Flandina, C.; Giammanco, M.
Int. J. Food Sci. Nutr.
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The reductive half-reaction of xanthine dehydrogenase from Rhodobacter capsulatus the role of Glu232 in catalysis
2014
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J. Biol. Chem.
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Kinetic study on the inhibition of xanthine oxidase by acylated derivatives of flavonoids synthesised enzymatically
2017
de Araujo, M.E.M.B.; Franco, Y.E.M.; Alberto, T.G.; Messias, M.C.F.; Leme, C.W.; Sawaya, A.C.H.F.; Carvalho, P.O.
J. Enzyme Inhib. Med. Chem.
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Serum adenosine deaminase and xanthine oxidase activities in silver catfish naturally infected with Ichthyophthirius multifiliis The influence of these enzymes on inflammatory and oxidative status
2018
Baldissera, M.D.; Souza, C.F.; Doleski, P.H.; Monteiro, S.G.; da Silva, A.S.; Baldisserotto, B.
J. Fish Dis.
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X-ray crystal structure of a xanthine oxidase complex with the flavonoid inhibitor quercetin
2014
Cao, H.; Pauff, J.M.; Hille, R.
J. Nat. Prod.
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Xanthine oxidase activity affects pro-oxidative and pro-inflammatory profiles in spleen of silver catfish experimentally infected with Aeromonas caviae
2017
Souza, C.F.; Verdi, C.M.; Baldissera, M.D.; Doleski, P.H.; Vizzotto, B.S.; Santos, R.C.V.; Baldisserotto, B.
Microb. Pathog.
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Arabidopsis xanthine dehydrogenase mutants defective in purine degradation show a compromised protective response to drought and oxidative stress
2014
Watanabe, S.; Kounosu, Y.; Shimada, H.; Sakamoto, A.
Plant Biotechnol.
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A Vitis vinifera xanthine dehydrogenase gene, VvXDH, enhances salinity tolerance in transgenic Arabidopsis
2017
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Plant Biotechnol. Rep.
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Opposing functions for plant xanthine dehydrogenase in response to powdery mildew infection production and scavenging of reactive oxygen species
2016
Hofmann, N.
Plant Cell
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Dual and opposing roles of xanthine dehydrogenase in defense-associated reactive oxygen species metabolism in Arabidopsis
2016
Ma, X.; Wang, W.; Bittner, F.; Schmidt, N.; Berkey, R.; Zhang, L.; King, H.; Zhang, Y.; Feng, J.; Wen, Y.; Tan, L.; Li, Y.; Zhang, Q.; Deng, Z.; Xiong, X.; Xiao, S.
Plant Cell
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Cloning, expression and biochemical characterization of xanthine and adenine phosphoribosyltransferases from Thermus thermophilus HB8
2018
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Biocatal. Biotransform.
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Crystal structures of acyclic nucleoside phosphonates in complex with Escherichia coli hypoxanthine phosphoribosyltransferase
2016
Eng, W.; Hockova, D.; Spacek, P.; Baszczynski, O.; Janeba, Z.; Naesens, L.; Keough, D.; Guddat, L.
ChemistrySelect
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Synthesis and evaluation of asymmetric acyclic nucleoside bisphosphonates as inhibitors of Plasmodium falciparum and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferase
2017
Spacek, P.; Keough, D.T.; Chavchich, M.; Dracinsky, M.; Janeba, Z.; Naesens, L.; Edstein, M.D.; Guddat, L.W.; Hockova, D.
J. Med. Chem.
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Molecular mechanism of regulation of the purine salvage enzyme XPRT by the alarmones pppGpp, ppGpp, and pGpp
2020
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J. Mol. Biol.
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Role of W181 in modulating kinetic properties of Plasmodium falciparum hypoxanthine guanine xanthine phosphoribosyltransferase
2016
Roy, S.; Karmakar, T.; Nagappa, L.K.; Prahlada Rao, V.S.; Balasubramanian, S.; Balaram, H.
Proteins
84
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Purification and characterization of an FeII- and alpha-ketoglutarate-dependent xanthine hydroxylase from Aspergillus oryzae
2021
Bocanegra-Jimenez, F.Y.; Montero-Moran, G.M.; Lara-Gonzalez, S.
Protein Expr. Purif.
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