Ligand 4-hydroxy-2-oxoglutarate

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Basic Ligand Information

Molecular Structure
Picture of 4-hydroxy-2-oxoglutarate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H6O6
4-hydroxy-2-oxoglutarate
WXSKVKPSMAHCSG-UHFFFAOYSA-N
Synonyms:
2-hydroxy-4-oxopentanedioic acid, 4-Hydroxy-2-ketoglutarate, 4-hydroxy-alpha-ketoglutarate, D,L-4-hydroxy-2-oxoglutarate, DL-2-keto-4-hydroxyglutarate, DL-4-hydroxy-2-oxoglutarate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
4-hydroxy-2-oxoglutarate = ?
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
4-hydroxy-L-glutamate + oxo acid = 4-hydroxy-2-oxoglutarate + L-glutamate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-asparagine + 4-hydroxy-2-oxoglutarate = 2-oxosuccinamate + 2-amino-4-hydroxyglutarate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
Glyoxylate + pyruvate = 4-Hydroxy-2-ketoglutarate
show the reaction diagram
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pyruvate + glyoxylate = 4-hydroxy-2-oxoglutarate
show the reaction diagram
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Glyoxylate + pyruvate = 4-Hydroxy-2-ketoglutarate
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
substrate inhibition, Ki: 35 mM
-
competitive
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (13 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (16 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.039
-
-

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
35
-
substrate inhibition

References & Links

Links to other databases for 4-hydroxy-2-oxoglutarate

ChEBI
PubChem
ChEBI
PubChem