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Ligand a very-long-chain mannosylinositol phospho-(2'R)-2'-hydroxyphytoceramide Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information
a very-long-chain mannosylinositol phospho-(2'R)-2'-hydroxyphytoceramide
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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1-phosphatidyl-1D-myo-inositol + a very-long-chain mannosylinositol phospho-(2'R)-2'-hydroxyphytoceramide = 1,2-diacyl-sn-glycerol + a very-long-chain mannosyl-diphosphoinositol-(2'R)-2'-hydroxyphytoceramide
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)
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GDP-alpha-D-mannose + a very-long-chain inositol phospho-(2'R)-2'-hydroxyphytoceramide = a very-long-chain mannosylinositol phospho-(2'R)-2'-hydroxyphytoceramide + GDP
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Substrate in Enzyme-catalyzed Reactions (1 result)
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1-phosphatidyl-1D-myo-inositol + a very-long-chain mannosylinositol phospho-(2'R)-2'-hydroxyphytoceramide = 1,2-diacyl-sn-glycerol + a very-long-chain mannosyl-diphosphoinositol-(2'R)-2'-hydroxyphytoceramide
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Product in Enzyme-catalyzed Reactions (1 result)
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GDP-alpha-D-mannose + a very-long-chain inositol phospho-(2'R)-2'-hydroxyphytoceramide = a very-long-chain mannosylinositol phospho-(2'R)-2'-hydroxyphytoceramide + GDP
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Enzyme Kinetic Parameters
References & Links Literature References (1)
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Synthesis of mannose-(inositol-P)2-ceramide, the major sphingolipid in Saccharomyces cerevisiae, requires the IPT1 (YDR072c) gene
1997
Dickson, R.; Nagiec, E.; Wells, G.; Nagiec, M.; Lester, R.
J. Biol. Chem.
272
29620-29625
Links to other databases for a very-long-chain mannosylinositol phospho-(2'R)-2'-hydroxyphytoceramide