print visible entries

print all entries

Ligand 1-phosphatidyl-1D-myo-inositol 4-phosphate

Basic Ligand Information

Molecular Structure

Related pathways

close all tables

open all tables

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (8 results)

top print hide

Show Natural Substrate (8 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.137

ATP + phosphatidylinositol-4-phosphate = ADP + phosphatidylinositol-3,4-bisphosphate

661328, 660643

-

2.7.1.149

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

686033, 758613

-

2.7.1.153

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate

708568, 707877

-

2.7.1.154

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate

660945, 662852, 738668, 739146, 761736, 760780, 761194, 761670

-

2.7.1.68

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

641827, 641855, 641844, 641846, 641843, 641839, 641842, 641848, 641854, 641831, 641835, 641851, 641852, 641847, 641845, 641853, 641856, 641850, 660641, 661757, 661660, 662494, 662546, 660965, 660875, 722723, 723653, 721706, 722784, 738659, 738106, 738787, 738794, 738790, 738912, 739178, 739315, 739370, 737960, 738090, 738165, 738176, 738199, 738288, 738651, 738599, 759537, 759692, 759168, 760179, 759034, 759179, 759416, 759475, 759964

-

2.7.1.68

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate

689477

-

2.7.1.68

2 entries

3.1.3.B4

phosphatidylinositol 4-phosphate + H2O = phosphatidylinositol + phosphate

752310, 750385, 750411, 750609, 750610, 752046, 752309

-

3.1.4.11

1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + diacylglycerol

751170, 751269, 751706, 751907

-

In Vivo Product in Enzyme-catalyzed Reactions (7 results)

top print hide

Show Natural Product (7 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.67

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

-

-

3.1.3.36

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate

-

-

3.1.3.36

phosphatidylinositol-4,5-bisphosphate + H2O = phosphatidylinositol-4-phosphate + phosphate

-

-

3.1.3.36

2 entries

3.1.3.56

1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate + H2O = phosphatidylinositol 4-phosphate + phosphate

646393, -

-

3.1.3.67

phosphatidylinositol-3,4-bisphosphate + H2O = phosphatidylinositol 4-phosphate + phosphate

653215

-

3.1.3.86

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate

-

-

3.1.3.95

1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate

-

-

Substrate in Enzyme-catalyzed Reactions (22 results)

top print hide

Show Substrate (22 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.137

ATP + phosphatidylinositol 4-phosphate = ADP + phosphatidylinositol 3,4-bisphosphate

640851, 640917, 640862, 640904, 640922, 640850, 661892

-

2.7.1.137

ATP + phosphatidylinositol-4-phosphate = ADP + phosphatidylinositol-3,4-bisphosphate

661328, 660643

-

2.7.1.137

2 entries

2.7.1.149

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

686033, 758613

-

2.7.1.150

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

660790

-

2.7.1.153

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate

708568, 707877, 708336

-

2.7.1.153

ATP + phosphatidylinositol 4-phosphate = ADP + phosphatidylinositol 4,5-diphosphate

393230, 393232, 587104

-

2.7.1.154

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate

660945, 662852, 672858, 738668, 739146, 640862, 761736, 760780, 761194, 761670

-

2.7.1.154

ATP + 1-phosphatidyl-1D-myo-inositol-4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate

640880, 640950, 640904, 640862

-

2.7.1.154

ATP + 1-phosphatidyl-1D-myo-inositol-4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-diphosphate

671183

-

2.7.1.68

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

641839, 641846, 641847, 641848, 641853, 641824, 641825, 641834, 641840, 641773, 641822, 641828, 641829, 641830, 641831, 641833, 641850, 641852, 641827, 641841, 641843, 641771, 641823, 641826, 641832, 641835, 641842, 641772, 641849, 641845, 641844, 641851, 641855, 641854, 641856, 660641, 661757, 661660, 662494, 662546, 660965, 660875, 673332, 673471, 672961, 672374, 676432, 676789, 676808, 673679, 674435, 674460, 675006, 675019, 675959, 673185, 691977, 694628, 722723, 723653, 721706, 722784, 738659, 738106, 738787, 738794, 738790, 738912, 739178, 739315, 739370, 737960, 738090, 738165, 738176, 738199, 738288, 738651, 738599, 759537, 759692, 759168, 760179, 759034, 759179, 759416, 759475, 759964

-

2.7.1.68

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate

689477

-

2.7.1.68

GTP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = GDP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

641849, 641829, 641825

-

2.7.1.153

2 entries

2.7.1.154

3 entries

2.7.1.68

3 entries

3.1.3.25

phosphatidylinositol 4-phosphate + H2O = phosphatidylinositol + phosphate

751172

-

3.1.3.78

phosphatidylinositol 4-phosphate + H2O = phosphatidylinositol + phosphate

697606

-

3.1.3.B4

1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate

769336, 771081

-

3.1.3.B4

phosphatidylinositol 4-phosphate + H2O = phosphatidylinositol + phosphate

731293, 732218, 752310, 750385, 750411, 750609, 750610, 752046, 752309, 751173

-

3.1.3.B4

phosphatidylinositol-4-phosphate + H2O = ?

694636

-

3.1.4.11

1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + diacylglycerol

751170, 751269, 751706, 751907, 749960

-

3.1.4.11

phosphatidylinositol 4-phosphate + H2O = 1D-myo-inositol 4,5-bisphosphate + diacylglycerol

653195, 669287

-

3.1.4.11

phosphatidylinositol 4-phosphate + H2O = ?

649330, 285216

-

3.1.4.11

phosphatidylinositol 4-phosphate = ?

135133, 135118, 135127, 135132, 135141

-

3.1.3.B4

3 entries

3.1.4.11

4 entries

3.6.1.52

phosphatidylinositol 4-phosphate + H2O = ?

757172

-

Product in Enzyme-catalyzed Reactions (25 results)

top print hide

Show Product (25 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.67

2'-dATP + 1-phosphatidyl-1D-myo-inositol = 2'-dADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

-

-

2.7.1.67

ADP + 1-phosphatidyl-1D-myo-inositol = AMP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

-

-

2.7.1.67

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

-

-

2.7.1.67

CTP + 1-phosphatidyl-1D-myo-inositol = CDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

-

-

2.7.1.67

dATP + 1-phosphatidyl-1D-myo-inositol = dADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

-

-

2.7.1.67

GTP + 1-phosphatidyl-1D-myo-inositol = GDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

-

-

2.7.1.67

ITP + 1-phosphatidyl-1D-myo-inositol = IDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

-

-

2.7.1.67

TTP + 1-phosphatidyl-1D-myo-inositol = TDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

-

-

2.7.1.67

UTP + 1-phosphatidyl-1D-myo-inositol = UDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

-

-

3.1.3.36

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate

-

-

3.1.3.36

D-myo-phosphatidylinositol 4,5-bisphosphate = D-myo-phosphatidylinositol 4-phosphate + phosphate

-

-

3.1.3.36

phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = phosphatidylinositol 4-phosphate + phosphate

134805, 134819, 134812, -

-

3.1.3.36

phosphatidylinositol 4,5-bisphosphate + H2O = phosphatidylinositol 4-phosphate + phosphate

-

-

3.1.3.36

phosphatidylinositol-4,5-bisphosphate + H2O = phosphatidylinositol-4-phosphate + phosphate

-

-

3.1.3.56

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate

-

-

3.1.3.56

1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate + H2O = phosphatidylinositol 4-phosphate + phosphate

- , 646393

-

2.7.1.67

9 entries

3.1.3.36

5 entries

3.1.3.56

2 entries

3.1.3.64

phosphatidylinositol 3,4-bisphosphate + H2O = phosphatidylinositol 4-phosphate + phosphate

646450

-

3.1.3.67

phosphatidylinositol 3,4-bisphosphate + H2O = phosphatidylinositol 4-phosphate + phosphate

653215, -

-

3.1.3.67

phosphatidylinositol 4,5-bisphosphate + H2O = phosphatidylinositol 4-phosphate + phosphate

-

-

3.1.3.67

phosphatidylinositol-3,4-bisphosphate + H2O = phosphatidylinositol 4-phosphate + phosphate

653215

-

3.1.3.67

phosphatidylinostitol 3,4-bisphosphate + H2O = phosphatidylinositol 4-phosphate + phosphate

651881

-

3.1.3.67

phosphatidylinositol-3,4-bisphosphate + H2O = phosphatidylinositol-4-monophosphate + phosphate

-

-

3.1.3.86

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate

-

-

3.1.3.86

phosphatidylinositol 4,5-bisphosphate + H2O = phosphatidylinositol 4-phosphate + phosphate

-

-

3.1.3.67

5 entries

3.1.3.86

2 entries

3.1.3.95

1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate

-

-

Activator in Enzyme-catalyzed Reactions (7 results)

top print hide

Show Activating Compound (7 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.91

0.01 mM, isoform SphK2, 89% of initial activity, isoform SphK1, 175% of initial activity

702037

-

3.1.3.64

phosphatidylinositol 4-phosphate increases myotubularin-related protein 6 activity in the presence of myotubularin-related protein 9 in 100% phosphatidylserine

698920

-

3.1.4.4

-

135446

-

3.1.4.4

only in vitro

135446

-

3.1.4.4

2 entries

3.4.22.B36

activates

648418

-

7.2.2.10

433% stimulation of activity at 1 mM

700250

-

7.6.2.1

the enzyme is activated after the binding of phosphatidylinositol 4-phosphate and release of the autoinhibitory domain

767618

-

Inhibitor in Enzyme-catalyzed Reactions (9 results)

top print hide

Show Inhibitors (9 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.67

-

641786, 641788

-

2.7.1.67

0.5 mg/ml, 42% inhibition

641787

-

2.7.1.67

0.6 mM, 80% inhibition

641799

-

2.7.1.67

3 entries

2.7.1.91

0.01 mM, isoform SphK2, 89% of initial activity, isoform SphK1, 175% of initial activity

702037

-

2.7.11.1

inhibits Sec2p phosphorylation by Yck2p

743271

-

2.7.7.41

55% inhibition at 1 mol%

737701

-

3.1.3.86

inhibition at low micromolar concentrations

715425

-

4.1.1.31

addition of 0.05 mM phosphatidic acid decreases PEPC activity to approximately 50% of the control activity

706331

-

4.1.1.31

promotes a conformational change within the PEPC protein, including exposure of the C-terminus and inactivation. The exposure of the C-terminus sensitizes the enzyme to degradation

771638

-

4.1.1.31

2 entries

Enzyme Kinetic Parameters

K_M Value (18 results)

top print hide

Show KM Value (18 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.7.1.137

0.009

-

-

640851

2.7.1.137

10

-

-

640917

2.7.1.137

2 entries

2.7.1.154

0.025

-

pH 7.5, 30°C, in presence of phosphatidylserine

640880

2.7.1.68

0.0012

-

in 1-phosphatidyl-1D-myo-inositol 4-phosphate in membranes, type I enzyme

641825

2.7.1.68

0.0014

-

in 1-phosphatidyl-1D-myo-inositol 4-phosphate liposomes, type I enzyme

641825

2.7.1.68

0.005

-

-

641771

2.7.1.68

0.006

-

in 1-phosphatidyl-1D-myo-inositol 4-phosphate micelles, type I enzyme

641825

2.7.1.68

0.01

-

pH 7.5, 25°C

641831

2.7.1.68

0.04

-

in 1-phosphatidyl-1D-myo-inositol 4-phosphate liposomes, type II enzyme

641825

2.7.1.68

0.047

-

pH 7.5, enzyme type Ialpha

641840

2.7.1.68

0.05

-

pH 7.5, enzyme type IIalpha

641840

2.7.1.68

0.06

-

in 1-phosphatidyl-1D-myo-inositol 4-phosphate micelles, type II enzyme

641825

2.7.1.68

0.065

-

recombinant enzyme form 10

661757

2.7.1.68

0.25

-

pH 7.4, 37°C

641822

2.7.1.68

0.262

-

pH 7.5, enzyme type Ibeta

641840

2.7.1.68

0.6

-

recombinant enzyme form 1

661757

2.7.1.68

4.1

-

recombinant isozyme alpha

661757

2.7.1.68

14 entries

3.1.4.11

0.031

-

-

135141

K_i Value (2 results)

top print hide

Show KI Value (2 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.7.1.67

0.235

-

room temperature

641786

2.7.1.67

0.774

-

room temperature

641786

2.7.1.67

2 entries

References & Links

Literature References (187)

top print hide

Show Reference (187 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

134805

8106379

Identification and characterization of the phosphatidylinositol-(4,5)-bisphosphate 5-phosphatase in human platelets

1994

Matzaris, M.; Jackson, S.P.; Laxminarayan, K.M.; Speed, C.J.; Mitchell, C.A.

J. Biol. Chem.

269

3397-33402

134812

214133

Studies on the properties of triphosphoinositide phosphomonoesterase and phosphodiesterase of rabbit iris smooth muscle

1978

Akhtar, R.A.; Abdel-Latif, A.A.

Biochim. Biophys. Acta

527

159-170

134819

7761412

The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphatase

1995

Zhang, X.; Jefferson, A.B.; Auethavekiat, V.; Majerus, P.W.

Proc. Natl. Acad. Sci. USA

92

4853-4856

135118

2822482

Identification of Ca2+-stimulated polyphosphoinositide phospholipase C in isolated plant plasma membranes

1987

Melin, P.M.; Sommarin, M.; Sandelius A.S.; Jergil, B.

FEBS Lett.

223

87-91

135127

6275838

The polyphosphoinositide phosphodiesterase of erythrocyte membranes

1981

Downes, C.P.; Michell, R.H.

Biochem. J.

198

133-140

135132

8004010

Phosphoinositidase C isozymes in SaOS-2 cells: immunocytochemical detection in nuclear and cytoplasmic compartments

1993

Maraldi, N.M.; Zini, N.; Santi, S.; Bavelloni, A.; Valmori, A.; Marmiroli, S.; Ognibene, A.

Biol. Cell.

79

243-250

135133

1325785

Discrete subcellular localization of phosphoinositidase C beta, gamma and delta in PC12 rat pheochromocytoma cells

1992

Mazzoni, M.; Bertagnolo, V.; Neri, L.M.; Carini, C.; Marchisio, M.; Milani, D.; Manzoli, F.A.; Capitani, S.

Biochem. Biophys. Res. Commun.

187

114-120

135141

1332858

Expression, purification and characterisation of a functional phosphatidylinositol-specific phospholipase C-delta1 protein in Escherichia coli

1992

Ginger, R.S.; Parker, P.J.

Eur. J. Biochem.

210

155-160

135446

10425392

Molecular and biochemical properties and physiological roles of plant phospholipase D

1999

Pappan, K.; Wang, X.

Biochim. Biophys. Acta

1439

151-166

285216

6316925

Resolution of myocardial phospholipase C into several forms with distinct properties

1983

Low, M.G.; Weglicki, W.B.

Biochem. J.

215

325-334

393230

11395417

Synthesis and function of 3-phosphorylated inositol lipids

2001

Vanhaesebroeck, B.; Leevers, S.J.; Ahmadi, K.; Timms, J.; Katso, R.; Driscoll, P.C.; Woscholski, R.; Parker, P.J.; Waterfield, M.D.

Annu. Rev. Biochem.

70

535-602

393232

9255069

Phosphoinositide 3-kinases: a conserved family of signal transducers

1997

Vanhaesebroeck, B.; Leevers, S.J.; Panayotou, G.; Waterfield, M.D.

Trends Biochem. Sci.

22

267-272

587104

9113989

P110delta, a novel phosphoinositide 3-kinase in leukocytes

1997

Vanhaesebroeck, B.; Welham, M.J.; Kotani, K.; Stein, R.; Warne, P.H.; Zvelebil, M.J.; Higashi, K.; Volinia, S.; Downward, J.; Waterfield, M.D.

Proc. Natl. Acad. Sci. USA

94

4330-4335

640850

2167854

Purification and characterization of bovine brain type I phosphatidylinositol kinase

1990

Morgan, S.J.; Smith, A.D.; Parker, P.J.

Eur. J. Biochem.

191

761-767

640851

2174051

Purification and characterization of phosphoinositide 3-kinase from rat liver

1990

Carpenter, C.L.; Duckworth, B.C.; Auger, K.R.; Cohen, B.; Schaffhausen, B.S.; Cantley, L.C.

J. Biol. Chem.

265

19704-19711

640862

9830063

Human phosphoinositide 3-kinase C2b, the role of calcium and the C2 domain in enzyme activity

1998

Arcaro, A.; Volinia, S.; Zvelebil, M.J.; Stein, R.; Watton, S.J.; Layton, M.J.; Gout, I.; Ahmadi, K.; Downward, J.; Waterfield, M.D.

J. Biol. Chem.

273

33082-33090

640880

-

Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin

1997

Domin, J.; Pages, F.; Volinia, S.; Rittenhouse, S.E.; Zvelebil, M.J.; Stein, R.C.; Waterfield, M.D.

Biochem. J.

326

139-147

640904

8662856

CpK is a novel class of Drosophila PtdIns 3-kinase containing a C2 domain

1996

Molz, L.; Chen, Y.W.; Hirano, M.; Williams, L.T.

J. Biol. Chem.

271

13892-13899

640917

9162050

Purification and characterization of Gbg-responsive phosphoinositide 3-kinases from pig platelet cytosol

1997

Tang, X.; Downes, C.P.

J. Biol. Chem.

272

14193-14199

640922

7628435

A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system

1995

Volinia, S.; Dhand, R.; Vanhaesebroeck, B.; MacDougall, L.; Stein, R.; Zvelebil, M.J.; Domin, J.; Panaretou, C.; Waterfield, M.D.

EMBO J.

14

3339-3348

640950

9516481

A novel class II phosphoinositide 3-kinase predominantly expressed in the liver and its enhanced expression during liver regeneration

1998

Ono, F.; Nakagawa, T.; Saito, S.; Owada, Y.; Sakagami, H.; Goto, K.; Suzuki, M.; Matsuno, S.; Kondo, H.

J. Biol. Chem.

273

7731-7736

641771

1323033

Phosphatidylinositol 4-kinase and phosphatidylinositol-4-phosphate 5-kinase from bovine brain membranes

1992

Moritz, A.; Westerman, J.; De Graan, P.N.E.; Wirtz, K.W.A.

Methods Enzymol.

209

202-211

641772

-

Phosphatidylinositol and phosphatidylinositolphosphate kinases in plant plasma membranes

1988

Sommarin, M.; Sandelius, A.S.

Biochim. Biophys. Acta

958

268-278

641773

12747

Phosphatidylinositol kinase and diphosphoinositide kinase of rat kidney cortex: properties and subcellular localization

1976

Cooper, P.H.; Hawthorne, J.N.

Biochem. J.

160

97-105

641786

2827737

Bovine brain contains two types of phosphatidylinositol kinase

1987

Endemann, G.; Dunn, S.N.; Cantley, L.C.

Biochemistry

26

6845-6852

641787

2837470

Purification and characterization of a phosphatidylinositol 4-kinase from bovine uteri

1988

Porter, F.D.; Li, Y.S.; Deuel, T.F.

J. Biol. Chem.

263

8989-8995

641788

3014004

Identification and characterization of the phosphatidylinositol kinase in membranes of murine T lymphocytes

1986

O'Shea, J.J.; Harford, J.B.; Klausner, R.D.

J. Immunol.

137

971-976

641799

2549013

Legionella micdadei protein kinase catalyzes phosphorylation of tubulin and phosphatidylinositol

1989

Saha, A.K.; Dowling, J.N.; Mukhopadhyay, N.K.; Glew, R.H.

J. Bacteriol.

171

5103-5110

641822

4295336

The diphosphoinositide kinase of rat brain

1968

Kai, M.; Salway, J.G.; Hawthorne, J.N.

Biochem. J.

106

791-801

641823

2152796

Purification of a phosphatidylinositol 4-phosphate kinase from bovine brain membranes

1990

Moritz, A.; De Graan, P.N.E.; Ekhart, P.F.; Gispen, W.H.; Wirtz, K.W.A.

J. Neurochem.

54

351-354

641824

-

The phosphatidylinositol 4-phosphate kinase of rat brain and human platelets

1986

Smith, P.M.; Wreggett, K.A.; Irvine, R.F.

Biochem. Soc. Trans.

14

1145-1146

641825

1323032

Phosphatidylinositol-4-phosphate 5-kinases from human erythrocytes

1992

Bazenet, C.E.; Anderson, R.A.

Methods Enzymol.

209

189-202

641826

2982368

Inhibition of phosphatidylinositol-4-phosphate kinase by its product phosphatidylinositol-4,5-bisphosphate

1985

Van Rooijen, L.A.A.; Rossowska, M.; Bazan, N.G.

Biochem. Biophys. Res. Commun.

126

150-155

641827

2536734

Activation of phosphatidylinositol kinase and phosphatidylinositol-4-phosphate kinase by cAMP in Saccharomyces cerevisiae

1989

Kato, H.; Uno, I.; Ishikawa, T.; Takenawa, T.

J. Biol. Chem.

264

3116-3121

641828

2822135

Activation of phosphatidylinositol-4-phosphate kinase in rat liver plasma membranes by polyamines

1987

Lundberg, G.A.; Sundler, R.; Jergil, B.

Biochim. Biophys. Acta

922

1-7

641829

3026313

Catalytic properties of a purified phosphatidylinositol-4-phosphate kinase from rat brain

1986

Cochet, C.; Chambaz, E.M.

Biochem. J.

237

25-31

641830

3023090

Phosphatidylinositol-4-phosphate kinase from rat brain. Activation by polyamines and inhibition by phosphatidylinositol 4,5-bisphosphate

1986

Lundberg, G.A.; Jergil, B.; Sundler, R.

Eur. J. Biochem.

161

257-262

641831

2157497

Purification and partial characterization of phosphatidylinositol-4-phosphate kinase from rat liver plasma membranes. Further evidence for a stimulatory G-protein

1990

Urumow, T.; Wieland, O.H.

Biochim. Biophys. Acta

1052

152-158

641832

2536286

Purification and kinetic properties of a soluble phosphatidylinositol-4-phosphate kinase of the bovine adrenal medulla with emphasis on its inhibition by calcium ions

1989

Husebye, E.S.; Flatmark, T.

Biochim. Biophys. Acta

1010

250-257

641833

6093768

Purification and partial characterization of the phosphatidylinositol 4-phosphate kinase from rat brain

1984

Van Dongen, C.J.; Zwiers, H.; Gispen, W.H.

Biochem. J.

223

197-203

641834

2538472

Characterization and purification of membrane-associated phosphatidylinositol-4-phosphate kinase from human red blood cells

1989

Ling, L.E.; Schulz, J.T.; Cantley, L.C.

J. Biol. Chem.

264

5080-5088

641835

1313792

Phosphatidic acid is a specific activator of phosphatidylinositol-4-phosphate kinase

1992

Moritz, A.; De Graan, P.N.E.; Gispen, W.H.; Wirtz, K.W.A.

J. Biol. Chem.

267

7207-7210

641839

11891857

Overexpression of murine phosphatidylinositol 4-phosphate 5-kinase type Ibeta disrupts a phosphatidylinositol 4,5 bisphosphate regulated endosomal pathway

2002

Galiano, F.J.; Ulug, E.T.; Davis, J.N.

J. Cell. Biochem.

85

131-145

641840

9211928

Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules

1997

Zhang, X.; Loijens, J.C.; Boronenkov, I.V.; Parker, G.J.; Norris, F.A.; Chen, J.; Thum, O.; Prestwich, G.D.; Majerus, P.W.; Anderson, R.A.

J. Biol. Chem.

272

17756-17761

641841

9346907

STT4 is an essential phosphatidylinositol 4-kinase that is a target of wortmannin in Saccharomyces cerevisiae

1997

Cutler, N.S.; Heitman, J.; Cardenas, M.E.

J. Biol. Chem.

272

27671-27677

641842

8955136

Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family

1996

Loijens, J.C.; Anderson, R.A.

J. Biol. Chem.

271

32937-32943

641843

9624177

Phosphatidylinositol-4-phosphate 5-kinase localized on the plasma membrane is essential for yeast cell morphogenesis

1998

Homma, K.; Terui, S.; Minemura, M.; Qadota, H.; Anraku, Y.; Kanaho, Y.; Ohya, Y.

J. Biol. Chem.

273

15779-15786

641844

9873063

Regulation of phosphatidylinositol 4-phosphate 5-kinase from Schizosaccharomyces pombe by casein kinase I

1999

Vancurova, I.; Choi, J.H.; Lin, H.; Kuret, J.; Vancura, A.

J. Biol. Chem.

274

1147-1155

641845

9753781

A gene encoding phosphatidylinositol-4-phosphate 5-kinase is induced by water stress and abscisic acid in Arabidopsis thaliana

1998

Mikami, K.; Katagiri, T.; Iuchi, S.; Yamaguchi-Shinozaki, K.; Shinozaki, K.

Plant J.

15

563-568

641846

11581249

Phosphatidylinositol-4-phosphate 5-kinase-1beta is essential for epidermal growth factor receptor-mediated endocytosis

2001

Barbieri, M.A.; Heath, C.M.; Peters, E.M.; Wells, A.; Davis, J.N.; Stahl, P.D.

J. Biol. Chem.

276

47212-47216

641847

12223494

Inhibition of phosphatidylinositol-4-phosphate 5-kinase Ialpha impairs localized actin remodeling and suppresses phagocytosis

2002

Coppolino, M.G.; Dierckman, R.; Loijens, J.; Collins, R.F.; Pouladi, M.; Jongstra-Bilen, J.; Schreiber, A.D.; Trimble, W.S.; Anderson, R.; Grinstein, S.

J. Biol. Chem.

277

43849-43857

641848

11877391

Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling

2002

Yamazaki, M.; Miyazaki, H.; Watanabe, H.; Sasaki, T.; Maehama, T.; Frohman, M.A.; Kanaho, Y.

J. Biol. Chem.

277

17226-17230

641849

8744418

Phosphatidylinositol phosphate 5-kinase: purification and inhibition studies

1996

Kwok, F.; Humpage, A.; Cheng, C.H.K.

Prep. Biochem. Biotechnol.

26

1-19

641850

10747863

Type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible for phosphatidylinositol 4,5-bisphosphate synthesis in the golgi compartment

2000

Jones, D.H.; Morris, J.B.; Morgan, C.P.; Kondo, H.; Irvine, R.F.; Cockcroft, S.

J. Biol. Chem.

275

13962-13966

641851

12055293

Phosphatidylinositol-4-phosphate 5-kinase activity is stimulated during temperature-induced morphogenesis in Candida albicans

2002

Hairfield, M.L.; Westwater, C.; Dolan, J.W.

Microbiology

148

1737-1746

641852

11604140

PIP kinase Ig is the major PI(4,5)P2 synthesizing enzyme at the synapse

2001

Wenk, M.R.; Pellegrini, L.; Klenchin, V.A.; Di Paolo, G.; Chang, S.; Daniell, L.; Arioka, M.; Martin, T.F.; De Camilli, P.

Neuron

32

79-88

641853

10679324

Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly

2000

Tolias, K.F.; Hartwig, J.H.; Ishihara, H.; Shibasaki, Y.; Cantley, L.C.; Carpenter, C.L.

Curr. Biol.

10

153-156

641854

10744700

Stimulation of phosphatidylinositol-4-phosphate 5-kinase by Rho-kinase

2000

Oude Weernink, P.A.; Schulte, P.; Guo, Y.; Wetzel, J.; Amano, M.; Kaibuchi, K.; Haverland, S.; Voss, M.; Schmidt, M.; Mayr, G.W.; Jakobs, K.H.

J. Biol. Chem.

275

10168-10174

641855

11087761

Phosphatidylinositol 4-phosphate 5-kinase type I is regulated through phosphorylation response by extracellular stimuli

2001

Park, S.J.; Itoh, T.; Takenawa, T.

J. Biol. Chem.

276

4781-4787

641856

11839279

Essential role of type I(alpha) phosphatidylinositol 4-phosphate 5-kinase in neurite remodeling

2002

van Horck, F.P.; Lavazais, E.; Eickholt, B.J.; Moolenaar, W.H.; Divecha, N.

Curr. Biol.

12

241-245

646393

7721860

Properties of type II inositol polyphosphate 5-phosphatase

1995

Jefferson, A.B.; Majerus, P.W.

J. Biol. Chem.

270

9370-9377

646450

11504939

Characterization of an adapter subunit to a phosphatidylinositol (3)P 3-phosphatase: Identification of a myotubularin-related protein lacking catalytic activity

2001

Nandurkar, H.H.; Caldwell, K.K.; Whisstock, J.C.; Layton, M.J.; Gaudet, E.A.; Norris, F.A.; Majerus, P.W.; Mitchell, C.A.

Proc. Natl. Acad. Sci. USA

98

9499-9504

648418

10446155

Characterization of two recombinant Drosophila calpains. CALPA and a novel homolog, CALPB

1999

Jekely, G.; Friedrich, P.

J. Biol. Chem.

274

23893-23900

649330

11395409

Regulation of phosphoinositide-specific phospholipase C

2001

Rhee, S.G.

Annu. Rev. Biochem.

70

281-312

651881

9593664

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

1998

Maehama, T.; Dixon, J.E.

J. Biol. Chem.

273

13375-13378

653195

12132576

Partial purification and properties of a phosphatidylinositol 4,5-bisphosphate hydrolyzing phospholipase C from the soluble fraction of soybean sprouts

2002

Park, S.K.; Lee, J.R.; Lee, S.S.; Son, H.J.; Yoo, J.Y.; Moon, J.C.; Kwon, H.Y.; Lim, C.O.; Bahk, J.D.; Cho, M.J.; Lee, S.Y.

Mol. Cells

13

377-384

653215

10866658

Phosphorylation of the PTEN tail regulates protein stability and function

2000

Vazquez, F.; Ramaswamy, S.; Nakamura, N.; Sellers, W.R.

Mol. Cell. Biol.

20

5010-5018

660641

12791386

Activation of PI(4)P 5-kinase by small G proteins

2003

Kanaho, Y.; Miyazaki, H.; Yamazaki, M.

Adv. Enzyme Regul.

43

107-119

660643

15581497

Phosphoinositide 3-kinase gamma mediates Jun kinase activation via its lipid-kinase activity

2004

Pietrucha, R.; Rubio, I.; Wymann, M.P.; Wetzker, R.

Adv. Enzyme Regul.

44

299-308

660790

12413484

Phosphatidylinositol 3,5-bisphosphate: metabolism and function

2002

Cooke, F.T.

Arch. Biochem. Biophys.

407

143-151

660875

15178428

Dibasic amino acid residues at the carboxy-terminal end of kinase homology domain participate in the plasma membrane localization and function of phosphatidylinositol 5-kinase gamma

2004

Arioka, M.; Nakashima, S.; Shibasaki, Y.; Kitamoto, K.

Biochem. Biophys. Res. Commun.

319

456-463

660945

11931646

Hepatocyte growth factor activates phosphoinositide 3-kinase C2beta in renal brush-border plasma membranes

2002

Crljen, V.; Volinia, S.; Banfic, H.

Biochem. J.

365

791-799

660965

14741049

A novel neuronal-specific splice variant of Type I phosphatidylinositol 4-phosphate 5-kinase isoform gamma

2004

Giudici, M.L.; Emson, P.C.; Irvine, R.F.

Biochem. J.

379

489-496

661328

15781393

Targeting the gatekeeper residue in phosphoinositide 3-kinases

2005

Alaimo, P.J.; Knight, Z.A.; Shokat, K.M.

Bioorg. Med. Chem.

13

2825-2836

661660

15464023

Regulation and cellular roles of phosphoinositide 5-kinases

2004

Oude Weernink, P.A.; Schmidt, M.; Jakobs, K.H.

Eur. J. Pharmacol.

500

87-99

661757

15949803

Characterization and comparative analysis of Arabidopsis phosphatidylinositol phosphate 5-kinase 10 reveals differences in Arabidopsis and human phosphatidylinositol phosphate kinases

2005

Perera, I.Y.; Davis, A.J.; Galanopoulou, D.; Im, Y.J.; Boss, W.F.

FEBS Lett.

579

3427-3432

661892

12672472

Class I phosphoinositide 3-kinases

2003

Anderson, K.E.; Jackson, S.P.

Int. J. Biochem. Cell Biol.

35

1028-1033

662494

12913109

Phosphatidylinositol phosphate 5-kinase Ibeta recruits AP-2 to the plasma membrane and regulates rates of constitutive endocytosis

2003

Padron, D.; Wang, Y.J.; Yamamoto, M.; Yin, H.; Roth, M.G.

J. Cell Biol.

162

693-701

662546

12925676

Arf6 and phosphoinositol-4-phosphate-5-kinase activities permit bypass of the Rac1 requirement for beta1 integrin-mediated bacterial uptake

2003

Wong, K.W.; Isberg, R.R.

J. Exp. Med.

198

603-614

662852

14701751

Targeted expression of the class II phosphoinositide 3-kinase in Drosophila melanogaster reveals lipid kinase-dependent effects on patterning and interactions with receptor signaling pathways

2004

MacDougall, L.K.; Gagou, M.E.; Leevers, S.J.; Hafen, E.; Waterfield, M.D.

Mol. Cell. Biol.

24

796-808

669287

15322077

RhoA activates purified phospholipase C-epsilon by a guanine nucleotide-dependent mechanism

2004

Seifert, J.P.; Wing, M.R.; Snyder, J.T.; Gershburg, S.; Sondek, J.; Harden, T.K.

J. Biol. Chem.

279

47992-47997

671183

16857245

Activation of phosphoinositide 3-kinase C2 beta in the nuclear matrix during compensatory liver growth

2006

Sindic, A.; Crljen, V.; Matkovic, K.; Lukinovic-Skudar, V.; Visnjic, D.; Banfic, H.

Adv. Enzyme Regul.

46

280-287

672374

17071135

The differential regulation of phosphatidylinositol 4-phosphate 5-kinases and phospholipase D1 by ADP-ribosylation factors 1 and 6

2006

Perez-Mansilla, B.; Ha, V.L.; Justin, N.; Wilkins, A.J.; Carpenter, C.L.; Thomas, G.M.

Biochim. Biophys. Acta

1761

1429-1442

672858

16777618

Are class II posphoinositide 3-kinases potential targets for anticancer therapies?

2006

Traer, C.J.; Foster, F.M.; Abraham, S.M.; Fry, M.J.

Bull. Cancer

93

E53-E58

672961

15994099

Phosphatidylinositol-4-phosphate 5-kinase gamma is associated with cell-cell junction in A431 epithelial cells

2005

Akiyama, C.; Shinozaki-Narikawa, N.; Kitazawa, T.; Hamakubo, T.; Kodama, T.; Shibasaki, Y.

Cell Biol. Int.

29

514-520

673185

16979564

A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis

2006

Halstead, J.R.; van Rheenen, J.; Snel, M.H.; Meeuws, S.; Mohammed, S.; DSantos, C.S.; Heck, A.J.; Jalink, K.; Divecha, N.

Curr. Biol.

16

1850-1856

673332

17290217

Role of activation of PIP5Kgamma661 by AP-2 complex in synaptic vesicle endocytosis

2007

Nakano-Kobayashi, A.; Yamazaki, M.; Unoki, T.; Hongu, T.; Murata, C.; Taguchi, R.; Katada, T.; Frohman, M.A.; Yokozeki, T.; Kanaho, Y.

EMBO J.

26

1105-1116

673471

17475243

Role of phosphatidylinositol-4-phosphate 5 kinase (ppk-1) in ovulation of Caenorhabditis elegans

2007

Xu, X.; Guo, H.; Wycuff, D.L.; Lee, M.

Exp. Cell Res.

313

2465-2475

673679

17157843

The intracellular localisation and mobility of Type Igamma phosphatidylinositol 4P 5-kinase splice variants

2006

Giudici, M.L.; Lee, K.; Lim, R.; Irvine, R.F.

FEBS Lett.

580

6933-6937

674435

15741172

Disturbance of sphingolipid biosynthesis abrogates the signaling of Mss4, phosphatidylinositol-4-phosphate 5-kinase, in yeast

2005

Kobayashi, T.; Takematsu, H.; Yamaji, T.; Hiramoto, S.; Kozutsumi, Y.

J. Biol. Chem.

280

18087-18094

674460

15923187

Phosphatidylinositol-4-phosphate 5-kinase regulates fission yeast cell integrity through a phospholipase C-mediated protein kinase C-independent pathway

2005

Deng, L.; Sugiura, R.; Ohta, K.; Tada, K.; Suzuki, M.; Hirata, M.; Nakamura, S.; Shuntoh, H.; Kuno, T.

J. Biol. Chem.

280

27561-27568

675006

15976455

Phospholipase D2 stimulates integrin-mediated adhesion via phosphatidylinositol 4-phosphate 5-kinase Igamma b

2005

Powner, D.J.; Payne, R.M.; Pettitt, T.R.; Giudici, M.L.; Irvine, R.F.; Wakelam, M.J.

J. Cell Sci.

118

2975-2986

675019

16888807

Phosphatidic acid regulates the affinity of the murine phosphatidylinositol 4-phosphate 5-kinase-Ibeta for phosphatidylinositol-4-phosphate

2007

Jarquin-Pardo, M.; Fitzpatrick, A.; Galiano, F.J.; First, E.A.; Davis, J.N.

J. Cell. Biochem.

100

112-128

675959

15870270

The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha

2005

Kisseleva, M.; Feng, Y.; Ward, M.; Song, C.; Anderson, R.A.; Longmore, G.D.

Mol. Cell. Biol.

25

3956-3966

676432

17220200

PIP5K9, an Arabidopsis phosphatidylinositol monophosphate kinase, interacts with a cytosolic invertase to negatively regulate sugar-mediated root growth

2007

Lou, Y.; Gou, J.Y.; Xue, H.W.

Plant Cell

19

163-181

676789

15793002

Phosphatidylinositol phosphate kinase type I gamma regulates dynamics of large dense-core vesicle fusion

2005

Gong, L.W.; Di Paolo, G.; Diaz, E.; Cestra, G.; Diaz, M.E.; Lindau, M.; De Camilli, P.; Toomre, D.

Proc. Natl. Acad. Sci. USA

102

5204-5209

676808

16880396

Stimulation of phosphatidylinositol kinase type I-mediated phosphatidylinositol (4,5)-bisphosphate synthesis by AP-2mu-cargo complexes

2006

Krauss, M.; Kukhtina, V.; Pechstein, A.; Haucke, V.

Proc. Natl. Acad. Sci. USA

103

11934-11939

686033

17303380

Genomic tagging of endogenous type IIbeta phosphatidylinositol 5-phosphate 4-kinase in DT40 cells reveals a nuclear localization

2007

Richardson, J.P.; Wang, M.; Clarke, J.H.; Patel, K.J.; Irvine, R.F.

Cell. Signal.

19

1309-1314

689477

18281506

The arabidopsis phosphatidylinositol phosphate 5-kinase PIP5K3 is a key regulator of root hair tip growth

2008

Kusano, H.; Testerink, C.; Vermeer, J.E.; Tsuge, T.; Shimada, H.; Oka, A.; Munnik, T.; Aoyama, T.

Plant Cell

20

367-380

691977

18037397

Overexpression of PPK-1, the Caenorhabditis elegans type I PIP kinase, inhibits growth cone collapse in the developing nervous system and causes axonal degeneration in adults

2008

Weinkove, D.; Bastiani, M.; Chessa, T.A.; Joshi, D.; Hauth, L.; Cooke, F.T.; Divecha, N.; Schuske, K.

Dev. Biol.

313

384-397

694628

18178770

The type B phosphatidylinositol-4-phosphate 5-kinase 3 is essential for root hair formation in Arabidopsis thaliana

2008

Stenzel, I.; Ischebeck, T.; Koenig, S.; Ho?ubowska, A.; Sporysz, M.; Hause, B.; Heilmann, I.

Plant Cell

20

124-141

694636

18281508

Root hair defective4 encodes a phosphatidylinositol-4-phosphate phosphatase required for proper root hair development in Arabidopsis thaliana

2008

Thole, J.M.; Vermeer, J.E.; Zhang, Y.; Gadella, T.W.; Nielsen, E.

Plant Cell

20

381-395

697606

12356723

Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology

2002

Niebuhr, K.; Giuriato, S.; Pedron, T.; Philpott, D.J.; Gaits, F.; Sable, J.; Sheetz, M.P.; Parsot, C.; Sansonetti, P.J.; Payrastre, B.

EMBO J.

21

5069-5078

698920

19038970

MTMR9 increases MTMR6 enzyme activity, stability, and role in apoptosis

2009

Zou, J.; Chang, S.C.; Marjanovic, J.; Majerus, P.W.

J. Biol. Chem.

284

2064-2071

700250

18988067

Dual mechanism of activation of plant plasma membrane Ca2+-ATPase by acidic phospholipids: evidence for a phospholipid binding site which overlaps the calmodulin-binding site

2008

Meneghelli, S.; Fusca, T.; Luoni, L.; De Michelis, M.I.

Mol. Membr. Biol.

25

539-546

702037

19168031

A lipid binding domain in sphingosine kinase 2

2009

Don, A.S.; Rosen, H.

Biochem. Biophys. Res. Commun.

380

87-92

706331

20007442

Phosphoenolpyruvate carboxylase from C4 leaves is selectively targeted for inhibition by anionic phospholipids

2010

Monreal, J.; McLoughlin, F.; Echevarría, C.; García-Mauriño, S.; Testerink, C.

Plant Physiol.

152

634-638

707877

20015408

Evidence that phosphatidylinositol 3-kinase is involved in sperm-induced tyrosine kinase signaling in Xenopus egg fertilization

2009

Mammadova, G.; Iwasaki, T.; Tokmakov, A.A.; Fukami, Y.; Sato, K.I.

BMC Dev. Biol.

9

68

708336

18403485

Distinct modes of activation of phosphatidylinositol 3-kinase in response to cyclic adenosine 3',5'-monophosphate or insulin-like growth factor I play different roles in regulation of cyclin D1 and p27Kip1 in FRTL-5 cells

2008

Fukushima, T.; Nedachi, T.; Akizawa, H.; Akahori, M.; Hakuno, F.; Takahashi, S.

Endocrinology

149

3729-3742

708568

19273082

Phosphatidylinositol 3-kinase: a key regulator in adherens junction formation and function

2009

Rivard, N.

Front. Biosci.

14

510-522

715425

8537357

Purification and biochemical characterization of a mammalian phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase

1995

Woscholski, R.; Waterfield, M.D.; Parker, P.J.

J. Biol. Chem.

270

31001-31007

721706

20435073

Advanced glycation end products inhibit Na+ K+ ATPase in proximal tubule epithelial cells: role of cytosolic phospholipase A2alpha and phosphatidylinositol 4-phosphate 5-kinase gamma

2010

Gallicchio, M.A.; Bach, L.A.

Biochim. Biophys. Acta

1803

919-930

722723

21795701

Phosphatidylinositol-4-phosphate 5-kinase and GEP100/Brag2 protein mediate antiangiogenic signaling by semaphorin 3E-plexin-D1 through Arf6 protein

2011

Sakurai, A.; Jian, X.; Lee, C.J.; Manavski, Y.; Chavakis, E.; Donaldson, J.; Randazzo, P.A.; Gutkind, J.S.

J. Biol. Chem.

286

34335-34345

722784

22942276

Phosphatidylinositol-4-phosphate 5-kinase isoforms exhibit acyl chain selectivity for both substrate and lipid activator

2012

Shulga, Y.V.; Anderson, R.A.; Topham, M.K.; Epand, R.M.

J. Biol. Chem.

287

35953-35963

723653

22307638

Phosphatidylinositol 4-phosphate 5-kinase alpha (PIPKalpha) regulates neuronal microtubule depolymerase kinesin, KIF2A and suppresses elongation of axon branches

2012

Noda, Y.; Niwa, S.; Homma, N.; Fukuda, H.; Imajo-Ohmi, S.; Hirokawa, N.

Proc. Natl. Acad. Sci. USA

109

1725-1730

731293

22452743

Allosteric activation of the phosphoinositide phosphatase Sac1 by anionic phospholipids

2012

Zhong, S.; Hsu, F.; Stefan, C.J.; Wu, X.; Patel, A.; Cosgrove, M.S.; Mao, Y.

Biochemistry

51

3170-3177

732218

25113029

Sac1-Vps74 structure reveals a mechanism to terminate phosphoinositide signaling in the Golgi apparatus

2014

Cai, Y.; Deng, Y.; Horenkamp, F.; Reinisch, K.M.; Burd, C.G.

J. Cell Biol.

206

485-491

737701

25375833

Distinct properties of the two isoforms of CDP-diacylglycerol synthase

2014

DSouza, K.; Kim, Y.J.; Balla, T.; Epand, R.M.

Biochemistry

53

7358-7367

737960

25152467

Preferential localization of type I phosphatidylinositol 4-phosphate 5-kinase gamma at the periactive zone of mouse photoreceptor ribbon synapses

2014

Sakagami, H.; Katsumata, O.; Hara, Y.; Tamaki, H.; Fukaya, M.

Brain Res.

1586

23-33

738090

23602387

Endosomal type Igamma PIP 5-kinase controls EGF receptor lysosomal sorting

2013

Sun, Y.; Hedman, A.C.; Tan, X.; Schill, N.J.; Anderson, R.A.

Dev. Cell

25

144-155

738106

23982733

IQGAP1 is a novel phosphatidylinositol 4,5 bisphosphate effector in regulation of directional cell migration

2013

Choi, S.; Thapa, N.; Hedman, A.C.; Li, Z.; Sacks, D.B.; Anderson, R.A.

EMBO J.

32

2617-2630

738165

23802628

Type I phosphatidylinositol 4-phosphate 5-kinase gamma is required for neuronal migration in the mouse developing cerebral cortex

2013

Hara, Y.; Fukaya, M.; Tamaki, H.; Sakagami, H.

Eur. J. Neurosci.

38

2659-2671

738176

23538529

Phosphatidylinositol 4-phosphate 5-kinase alpha negatively regulates nerve growth factor-induced neurite outgrowth in PC12 cells

2013

Liu, T.; Lee, S.Y.

Exp. Mol. Med.

45

e16

738199

25713054

Type I phosphatidylinositol 4-phosphate 5-kinase homo- and heterodimerization determines its membrane localization and activity

2015

Lacalle, R.A.; de Karam, J.C.; Martinez-Munoz, L.; Artetxe, I.; Peregil, R.M.; Sot, J.; Rojas, A.M.; Goni, F.M.; Mellado, M.; Manes, S.

FASEB J.

29

2371-2385

738288

27242793

Phosphatidylinositol 4-phosphate 5-kinases in the regulation of T cell activation

2016

Porciello, N.; Kunkl, M.; Viola, A.; Tuosto, L.

Front. Immunol.

7

186

738599

24151076

Phosphatidylinositol phosphate 5-kinase Igammai2 in association with Src controls anchorage-independent growth of tumor cells

2013

Thapa, N.; Choi, S.; Hedman, A.; Tan, X.; Anderson, R.A.

J. Biol. Chem.

288

34707-34718

738651

26070568

Phosphatidylinositol phosphate 5-kinase Igamma and phosphoinositide 3-kinase/Akt signaling couple to promote oncogenic growth

2015

Thapa, N.; Choi, S.; Tan, X.; Wise, T.; Anderson, R.A.

J. Biol. Chem.

290

18843-18854

738659

26157143

Phosphatidylinositol-4-phosphate 5-kinase 1alpha modulates ribosomal RNA gene silencing through its interaction with histone H3 lysine 9 trimethylation and heterochromatin protein HP1-alpha

2015

Chakrabarti, R.; Sanyal, S.; Ghosh, A.; Bhar, K.; Das, C.; Siddhanta, A.

J. Biol. Chem.

290

20893-20903

738668

25614622

Phosphatidylinositol 3-kinase class II alpha-isoform PI3K-C2alpha is required for transforming growth factor beta-induced Smad signaling in endothelial cells

2015

Aki, S.; Yoshioka, K.; Okamoto, Y.; Takuwa, N.; Takuwa, Y.

J. Biol. Chem.

290

6086-6105

738787

23589613

Phosphatidylinositol 4-phosphate 5-kinase alpha activation critically contributes to CD28-dependent signaling responses

2013

Muscolini, M.; Camperio, C.; Capuano, C.; Caristi, S.; Piccolella, E.; Galandrini, R.; Tuosto, L.

J. Immunol.

190

5279-5286

738790

25539813

Phosphatidylinositol 4-phosphate 5-kinase alpha and Vav1 mutual cooperation in CD28-mediated actin remodeling and signaling functions

2015

Muscolini, M.; Camperio, C.; Porciello, N.; Caristi, S.; Capuano, C.; Viola, A.; Galandrini, R.; Tuosto, L.

J. Immunol.

194

1323-1333

738794

26773155

Phosphatidylinositol 4-phosphate 5-kinase beta controls recruitment of lipid rafts into the immunological synapse

2016

Kallikourdis, M.; Trovato, A.E.; Roselli, G.; Muscolini, M.; Porciello, N.; Tuosto, L.; Viola, A.

J. Immunol.

196

1955-1963

738912

25704028

Phosphatidylinositol4-phosphate 5-kinase prevents the decrease in the HERG potassium current induced by Gq protein-coupled receptor stimulation

2015

Kubo, T.; Ding, W.G.; Toyoda, F.; Fujii, Y.; Omatsu-Kanbe, M.; Matsuura, H.

J. Pharmacol. Sci.

127

127-134

739146

25779105

The class II PI 3-kinase, PI3KC2alpha, links platelet internal membrane structure to shear-dependent adhesive function

2015

Mountford, J.K.; Petitjean, C.; Putra, H.W.; McCafferty, J.A.; Setiabakti, N.M.; Lee, H.; T?nnesen, L.L.; McFadyen, J.D.; Schoenwaelder, S.M.; Eckly, A.; Gachet, C.; Ellis, S.; Voss, A.K.; Dickins, R.A.; Hamilton, J.R.; Jackson, S.P.

Nat. Commun.

6

6535

739178

23680464

Phosphatidylinositol 4-phosphate 5-kinase beta regulates growth cone morphology and semaphorin 3A-triggered growth cone collapse in mouse dorsal root ganglion neurons

2013

Yamazaki, M.; Yamauchi, Y.; Goshima, Y.; Kanaho, Y.

Neurosci. Lett.

547

59-64

739315

25477067

Phosphatidylinositol phosphate 5-kinase genes respond to phosphate deficiency for root hair elongation in Arabidopsis thaliana

2015

Wada, Y.; Kusano, H.; Tsuge, T.; Aoyama, T.

Plant J.

81

426-437

739370

27457979

Phosphatidylinositol 4-phosphate 5-kinases 1 and 2 are involved in the regulation of vacuole morphology during Arabidopsis thaliana pollen development

2016

Ugalde, J.M.; Rodriguez-Furlan, C.; Rycke, R.D.; Norambuena, L.; Friml, J.; Leon, G.; Tejos, R.

Plant Sci.

250

10-19

743271

-

The casein kinases Yck1p and Yck2p act in the secretory pathway, in part, by regulating the Rab exchange factor Sec2p

2016

Stalder, D.; Novick, P.

Mol. Biol. Cell

27

686-701

749960

26825689

Biochemical characterization of the tomato phosphatidylinositol-specific phospholipase C (PI-PLC) family and its role in plant immunity

2016

Abd-El-Haliem, A.M.; Vossen, J.H.; van Zeijl, A.; Dezhsetan, S.; Testerink, C.; Seidl, M.F.; Beck, M.; Strutt, J.; Robatzek, S.; Joosten, M.H.A.J.

Biochim. Biophys. Acta

1861

1365-1378

749960

26825689

Biochemical characterization of the tomato phosphatidylinositol-specific phospholipase C (PI-PLC) family and its role in plant immunity

2016

Abd-El-Haliem, A.M.; Vossen, J.H.; van Zeijl, A.; Dezhsetan, S.; Testerink, C.; Seidl, M.F.; Beck, M.; Strutt, J.; Robatzek, S.; Joosten, M.H.A.J.

Biochim. Biophys. Acta

1861

1365-1378

750385

29752385

The phosphoinositide phosphatase Sac1 regulates cell shape and microtubule stability in the developing Drosophila eye

2018

Del Bel, L.M.; Griffiths, N.; Wilk, R.; Wei, H.C.; Blagoveshchenskaya, A.; Burgess, J.; Polevoy, G.; Price, J.V.; Mayinger, P.; Brill, J.A.

Development

145

151571

750385

29752385

The phosphoinositide phosphatase Sac1 regulates cell shape and microtubule stability in the developing Drosophila eye

2018

Del Bel, L.M.; Griffiths, N.; Wilk, R.; Wei, H.C.; Blagoveshchenskaya, A.; Burgess, J.; Polevoy, G.; Price, J.V.; Mayinger, P.; Brill, J.A.

Development

145

151571

749960

2 entries

750385

2 entries

750411

29461204

SAC1 degrades its lipid substrate PtdIns4P in the endoplasmic reticulum to maintain a steep chemical gradient with donor membranes

2018

Zewe, J.P.; Wills, R.C.; Sangappa, S.; Goulden, B.D.; Hammond, G.R.

eLife

7

e35588

750609

30448513

Accumulation of PtdIns(4)P at the Golgi mediated by reversible oxidation of the PtdIns(4)P phosphatase Sac1 by H2O2

2019

Lim, J.M.; Park, S.; Lee, M.S.; Balla, T.; Kang, D.; Rhee, S.G.

Free Radic. Biol. Med.

130

426-435

750610

30476538

Inactivation of the PtdIns(4)P phosphatase Sac1 at the Golgi by H2O2 produced via Ca2+-dependent Duox in EGF-stimulated cells

2019

Park, S.; Lim, J.M.; Park, S.H.; Kim, S.; Heo, S.; Balla, T.; Jeong, W.; Rhee, S.G.; Kang, D.

Free Radic. Biol. Med.

131

40-49

751170

25658460

Regulation of phosphatidylinositol-specific phospholipase C at the nuclear envelope in cardiac myocytes

2015

Smrcka, A.V.

J. Cardiovasc. Pharmacol.

65

203-210

751172

25869668

Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway

2015

Nakatsu, F.; Messa, M.; Nandez, R.; Czapla, H.; Zou, Y.; Strittmatter, S.M.; De Camilli, P.

J. Cell Biol.

209

85-95

751172

25869668

Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway

2015

Nakatsu, F.; Messa, M.; Nandez, R.; Czapla, H.; Zou, Y.; Strittmatter, S.M.; De Camilli, P.

J. Cell Biol.

209

85-95

751172

2 entries

751173

25869669

Spatiotemporal control of phosphatidylinositol 4-phosphate by Sac2 regulates endocytic recycling

2015

Hsu, F.; Hu, F.; Mao, Y.

J. Cell Biol.

209

97-110

751269

28097830

Plant phosphatidylinositol-specific phospholipase C at the center of plant innate immunity

2017

Abd-El-Haliem, A.M.; Joosten, M.H.

J. Integr. Plant Biol.

59

164-179

751269

28097830

Plant phosphatidylinositol-specific phospholipase C at the center of plant innate immunity

2017

Abd-El-Haliem, A.M.; Joosten, M.H.

J. Integr. Plant Biol.

59

164-179

751706

28157263

A phosphoinositide-specific phospholipase C pathway elicits stress-induced Ca2+ signals and confers salt tolerance to rice

2017

Li, L.; Wang, F.; Yan, P.; Jing, W.; Zhang, C.; Kudla, J.; Zhang, W.

New Phytol.

214

1172-1187

751706

28157263

A phosphoinositide-specific phospholipase C pathway elicits stress-induced Ca2+ signals and confers salt tolerance to rice

2017

Li, L.; Wang, F.; Yan, P.; Jing, W.; Zhang, C.; Kudla, J.; Zhang, W.

New Phytol.

214

1172-1187

751907

26401841

Arabidopsis AtPLC2 is a primary phosphoinositide-specific phospholipase C in phosphoinositide metabolism and the endoplasmic reticulum stress response

2015

Kanehara, K.; Yu, C.Y.; Cho, Y.; Cheong, W.F.; Torta, F.; Shui, G.; Wenk, M.R.; Nakamura, Y.

PLoS Genet.

11

e1005511

751907

26401841

Arabidopsis AtPLC2 is a primary phosphoinositide-specific phospholipase C in phosphoinositide metabolism and the endoplasmic reticulum stress response

2015

Kanehara, K.; Yu, C.Y.; Cho, Y.; Cheong, W.F.; Torta, F.; Shui, G.; Wenk, M.R.; Nakamura, Y.

PLoS Genet.

11

e1005511

752046

27044099

Lenz-Majewski mutations in PTDSS1 affect phosphatidylinositol 4-phosphate metabolism at ER-PM and ER-Golgi junctions

2016

Sohn, M.; Ivanova, P.; Brown, H.A.; Toth, D.J.; Varnai, P.; Kim, Y.J.; Balla, T.

Proc. Natl. Acad. Sci. USA

113

4314-4319

752046

27044099

Lenz-Majewski mutations in PTDSS1 affect phosphatidylinositol 4-phosphate metabolism at ER-PM and ER-Golgi junctions

2016

Sohn, M.; Ivanova, P.; Brown, H.A.; Toth, D.J.; Varnai, P.; Kim, Y.J.; Balla, T.

Proc. Natl. Acad. Sci. USA

113

4314-4319

751269

2 entries

751706

2 entries

751907

2 entries

752046

2 entries

752309

28471037

Oxysterol-binding protein recruitment and activity at the endoplasmic reticulum-Golgi interface are independent of Sac1

2017

Charman, M.; Goto, A.; Ridgway, N.D.

Traffic

18

519-529

752310

29411923

Sac1, a lipid phosphatase at the interface of vesicular and nonvesicular transport

2018

Del Bel, L.M.; Brill, J.A.

Traffic

19

301-318

757172

26828065

A novel inositol pyrophosphate phosphatase in Saccharomyces cerevisiae Siw14 protein selectively cleaves the beta-phosphate from 5-diphosphoinositol pentakisphosphate (5PP-IP5)

2016

Steidle, E.A.; Chong, L.S.; Wu, M.; Crooke, E.; Fiedler, D.; Resnick, A.C.; Rolfes, R.J.

J. Biol. Chem.

291

6772-6783

757172

26828065

A novel inositol pyrophosphate phosphatase in Saccharomyces cerevisiae Siw14 protein selectively cleaves the beta-phosphate from 5-diphosphoinositol pentakisphosphate (5PP-IP5)

2016

Steidle, E.A.; Chong, L.S.; Wu, M.; Crooke, E.; Fiedler, D.; Resnick, A.C.; Rolfes, R.J.

J. Biol. Chem.

291

6772-6783

757172

2 entries

758613

26710750

Phosphatidylinositol 5-phosphate 4-kinase gamma (PI5P4Kgamma), a lipid signalling enigma

2016

Giudici, M.; Clarke, J.; Irvine, R.

Adv. Biol. Regul.

61

47-50

759034

28711717

Phosphatidylinositol 4-phosphate 5-kinase alpha contributes to toll-like receptor 2-mediated immune responses in microglial cells stimulated with lipoteichoic acid

2017

Nguyen, T.T.N.; Seo, E.; Choi, J.; Le, O.T.T.; Kim, J.Y.; Jou, I.; Lee, S.Y.

Cell. Signal.

38

159-170

759034

28711717

Phosphatidylinositol 4-phosphate 5-kinase alpha contributes to toll-like receptor 2-mediated immune responses in microglial cells stimulated with lipoteichoic acid

2017

Nguyen, T.T.N.; Seo, E.; Choi, J.; Le, O.T.T.; Kim, J.Y.; Jou, I.; Lee, S.Y.

Cell. Signal.

38

159-170

759034

2 entries

759168

32686865

Phosphatidylinositol-4-phosphate 5-kinase type 1alpha attenuates Abeta production by promoting non-amyloidogenic processing of amyloid precursor protein

2020

Wu, P.F.; Bhore, N.; Lee, Y.L.; Chou, J.Y.; Chen, Y.W.; Wu, P.Y.; Hsu, W.M.; Lee, H.; Huang, Y.S.; Lu, P.J.; Liao, Y.F.

FASEB J.

34

12127-12146

759179

30843363

PtdIns(4,5)P2 is generated by a novel phosphatidylinositol 4-phosphate 5-kinase in the protist parasite Entamoeba histolytica

2019

Sharma, S.; Bhattacharya, S.; Bhattacharya, A.

FEBS J.

286

2216-2234

759179

30843363

PtdIns(4,5)P2 is generated by a novel phosphatidylinositol 4-phosphate 5-kinase in the protist parasite Entamoeba histolytica

2019

Sharma, S.; Bhattacharya, S.; Bhattacharya, A.

FEBS J.

286

2216-2234

759416

30734271

Localization of phosphatidylinositol 4-phosphate 5-kinase (PIP5K) alpha, beta, gamma in the three major salivary glands in situ of mice and their response to beta-adrenoceptor stimulation

2019

Khrongyut, S.; Rawangwong, A.; Pidsaya, A.; Sakagami, H.; Kondo, H.; Hipkaeo, W.

J. Anat.

234

502-514

759416

30734271

Localization of phosphatidylinositol 4-phosphate 5-kinase (PIP5K) alpha, beta, gamma in the three major salivary glands in situ of mice and their response to beta-adrenoceptor stimulation

2019

Khrongyut, S.; Rawangwong, A.; Pidsaya, A.; Sakagami, H.; Kondo, H.; Hipkaeo, W.

J. Anat.

234

502-514

759179

2 entries

759416

2 entries

759475

27557663

Type I gamma phosphatidylinositol phosphate 5-kinase i5 controls the ubiquitination and degradation of the tumor suppressor mitogen-inducible gene 6

2016

Sun, M.; Cai, J.; Anderson, R.A.; Sun, Y.

J. Biol. Chem.

291

21461-21473

759537

31831523

Plasma membrane processes are differentially regulated by type I phosphatidylinositol phosphate 5-kinases and RASSF4

2020

De La Cruz, L.; Traynor-Kaplan, A.; Vivas, O.; Hille, B.; Jensen, J.

J. Cell Sci.

133

jcs233254

759692

32376619

Type I phosphatidylinositol-4-phosphate 5-kinases alpha and gamma play a key role in targeting HIV-1 Pr55Gag to the plasma membrane

2020

Gonzales, B.; de Rocquigny, H.; Beziau, A.; Durand, S.; Burlaud-Gaillard, J.; Lefebvre, A.; Krull, S.; Emond, P.; Brand, D.; Piver, E.

J. Virol.

94

e00189-20

759692

32376619

Type I phosphatidylinositol-4-phosphate 5-kinases alpha and gamma play a key role in targeting HIV-1 Pr55Gag to the plasma membrane

2020

Gonzales, B.; de Rocquigny, H.; Beziau, A.; Durand, S.; Burlaud-Gaillard, J.; Lefebvre, A.; Krull, S.; Emond, P.; Brand, D.; Piver, E.

J. Virol.

94

e00189-20

759964

28949047

Arabidopsis phosphatidylinositol 4-phosphate 5-kinase 2 contains a functional nuclear localization sequence and interacts with alpha-importins

2017

Gerth, K.; Lin, F.; Daamen, F.; Menzel, W.; Heinrich, F.; Heilmann, M.

Plant J.

92

862-878

759964

28949047

Arabidopsis phosphatidylinositol 4-phosphate 5-kinase 2 contains a functional nuclear localization sequence and interacts with alpha-importins

2017

Gerth, K.; Lin, F.; Daamen, F.; Menzel, W.; Heinrich, F.; Heilmann, M.

Plant J.

92

862-878

759692

2 entries

759964

2 entries

760179

31616009

Enforced expression of phosphatidylinositol 4-phosphate 5-kinase homolog alters PtdIns(4,5)P2 distribution and the localization of small G-proteins

2019

Yang, Y.; Park, M.; Maekawa, M.; Fairn, G.D.

Sci. Rep.

9

14789

760780

27538808

Sevoflurane and isoflurane inhibit KCl-induced Class II phosphoinositide 3-kinase alpha subunit mediated vasoconstriction in rat aorta

2016

Yang, S.; Wu, Q.; Huang, S.; Wang, Z.; Qi, F.

BMC Anesthesiol.

16

63

760780

27538808

Sevoflurane and isoflurane inhibit KCl-induced Class II phosphoinositide 3-kinase alpha subunit mediated vasoconstriction in rat aorta

2016

Yang, S.; Wu, Q.; Huang, S.; Wang, Z.; Qi, F.

BMC Anesthesiol.

16

63

761194

28410969

Characterization and mechanism of phosphoinositide 3-kinases (PI3Ks) members in insulin-induced changes of protein metabolism in yellow catfish Pelteobagrus fulvidraco

2017

Zhuo, M.Q.; Pan, Y.X.; Wu, K.; Xu, Y.H.; Luo, Z.

Gen. Comp. Endocrinol.

247

34-45

761194

28410969

Characterization and mechanism of phosphoinositide 3-kinases (PI3Ks) members in insulin-induced changes of protein metabolism in yellow catfish Pelteobagrus fulvidraco

2017

Zhuo, M.Q.; Pan, Y.X.; Wu, K.; Xu, Y.H.; Luo, Z.

Gen. Comp. Endocrinol.

247

34-45

760780

2 entries

761194

2 entries

761670

27644332

Class II phosphoinositide 3-kinases as novel drug targets

2017

Falasca, M.; Hamilton, J.R.; Selvadurai, M.; Sundaram, K.; Adamska, A.; Thompson, P.E.

J. Med. Chem.

60

47-65

761736

30374841

The class II phosphoinositide 3-kinases PI3K-C2alpha and PI3K-C2beta differentially regulate clathrin-dependent pinocytosis in human vascular endothelial cells

2019

Aung, K.T.; Yoshioka, K.; Aki, S.; Ishimaru, K.; Takuwa, N.; Takuwa, Y.

J. Physiol. Sci.

69

263-280

761736

30374841

The class II phosphoinositide 3-kinases PI3K-C2alpha and PI3K-C2beta differentially regulate clathrin-dependent pinocytosis in human vascular endothelial cells

2019

Aung, K.T.; Yoshioka, K.; Aki, S.; Ishimaru, K.; Takuwa, N.; Takuwa, Y.

J. Physiol. Sci.

69

263-280

761736

2 entries

767618

31243363

Structure and autoregulation of a P4-ATPase lipid flippase

2019

Timcenko, M.; Lyons, J.; Januliene, D.; Ulstrup, J.; Dieudonne, T.; Montigny, C.; Ash, M.; Karlsen, J.; Boesen, T.; Kuehlbrandt, W.; Lenoir, G.; Moeller, A.; Nissen, P.

Nature

571

366-370

769336

35640825

Essential roles of phosphatidylinositol 4-phosphate phosphatases Sac1p and Sjl3p in yeast autophagosome formation

2022

Muramoto, M.; Yamakuchi, Y.; Konishi, R.; Koudatsu, S.; Tomikura, H.; Fukuda, K.; Kuriyama, S.; Kurokawa, Y.; Masatani, T.; Tamaki, H.; Fujita, A.

Biochim. Biophys. Acta

1867

159184

771081

35816160

Sac1 phosphatidylinositol 4-phosphate phosphatase is a novel host cell factor regulating hepatitis B virus particles assembly and release

2022

Popescu, M.A.; Patriche, D.; Dobrica, M.O.; Pantazica, A.M.; Flintoaca Alexandru, P.R.; Rouille, Y.; Popescu, C.I.; Branza-Nichita, N.

FEBS J.

289

7486-7499

771638

31143196

Anionic phospholipids induce conformational changes in phosphoenolpyruvate carboxylase to increase sensitivity to cathepsin proteases

2019

Gandullo, J.; Monreal, J.; Alvarez, R.; Dixadaz, I.; Garcixada-Maurino, S.; EchevarrÃia, C.

Front. Plant Sci.

10

582

Links to other databases for 1-phosphatidyl-1D-myo-inositol 4-phosphate

top print hide

Show Links (1 entry)