Ligand 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oic acid

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Basic Ligand Information

Molecular Structure
Picture of 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C24H38O5
7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oic acid
OEKUSRBIIZNLHZ-DJDNIQJZSA-N
Synonyms:
3-dehydrocholate, 3-oxo-cholic acid, 7alpha,12alpha-dihydroxy-5-beta-cholan-3-one-24-oic acid, 7alpha,12alpha-dihydroxy-5beta-cholan-3-one-24-oic acid
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oic acid + NADH + H+ = 3beta,7alpha,12alpha-trihydroxy-5beta-cholan-24-oic acid + NAD+
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3-oxo-cholic acid + NADPH + H+ = cholic acid + NADP+
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7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oic acid + NADH + H+ = 3beta,7alpha,12alpha-trihydroxy-5beta-cholan-24-oic acid + NAD+
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
cholic acid + NADP+ = 3-oxo-cholic acid + NADPH + H+
show the reaction diagram
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cholate + NAD+ = 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oic acid + NADH + H+
show the reaction diagram
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cholic acid + NAD+ = 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oic acid + NADH
show the reaction diagram
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3-dehydrocholoyl-CoA + H2O = 3-dehydrocholate + CoA
show the reaction diagram
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Enzyme Kinetic Parameters

References & Links

Links to other databases for 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oic acid

ChEBI
PubChem
ChEBI
PubChem