Ligand (+)-costunolide

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Basic Ligand Information

Molecular Structure
Picture of (+)-costunolide (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C15H20O2
(+)-costunolide
HRYLQFBHBWLLLL-AHNJNIBGSA-N
Synonyms:
Costunolide

Show all pahtways known for Show all BRENDA pathways known for (+)-costunolide

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(+)-costunolide + NADPH = 11(S),13-dihydrocostunolide + NADP+
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
germacra-1(10),4,11(13)-trien-12-oate + NADPH + H+ + O2 = (+)-costunolide + NADP+ + 2 H2O
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(+)-costunolide + NADPH = 11(S),13-dihydrocostunolide + NADP+
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
germacra-1(10),4,11(13)-trien-12-oate + NADPH + H+ + O2 = (+)-costunolide + NADP+ + 2 H2O
show the reaction diagram
-
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Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.5 mM, 30C, pH 6.8, 56.5% inhibition
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Enzyme Kinetic Parameters

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.4351
-
30C, pH 6.8

References & Links

Links to other databases for (+)-costunolide

ChEBI
PubChem
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PubChem