We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Ligand tryptamine-4,5-dione Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C1 0 H1 0 N2 O2
tryptamine-4,5-dione
IEEQBAOIHWUWBM-UHFFFAOYSA-N
Roles as Enzyme Ligand
In Vivo Product in Enzyme-catalyzed Reactions (1 result)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
serotonin + H2O2 + H+ = tryptamine dione + H2O
-
Product in Enzyme-catalyzed Reactions (2 results)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
serotonin + H2O2 + H+ = tryptamine dione + H2O
-
serotonin + superoxide = tryptamine-4,5-dione + H2O
-
Inhibitor in Enzyme-catalyzed Reactions (3 results)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
inhibition is blocked by reduced glutathione or cysteine at large molar excess, ascorbate protects partially
-
rapid inhibition, 87.7% reduced activity at 0.1 mM, inhibition is blocked by reduced glutathione or cysteine at large molar excess, ascorbate protects partially, inhibition is not affected by catalase and superoxide dismutase
-
Enzyme Kinetic Parameters
References & Links Literature References (2)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Inhibition of the alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase complexes by a putative aberrant metabolite of serotonin, tryptamine-4,5-dione
2002
Jiang, X.R.; Dryhurst, G.
Chem. Res. Toxicol.
15
1242-1247
The alpha-ketoglutarate-dehydrogenase complex: a mediator between mitochondria and oxidative stress in neurodegeneration
2005
Gibson, G.E.; Blass, J.P.; Beal, M.F.; Bunik, V.
Mol. Neurobiol.
31
43-63
Links to other databases for tryptamine-4,5-dione