Ligand N-oxalylglycine

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of N-oxalylglycine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H5NO5
N-oxalylglycine
BIMZLRFONYSTPT-UHFFFAOYSA-N
Synonyms:
N-oxaloylglycine, oxalglycine, oxalylglycine

Show all pahtways known for Show all pathways known for N-oxalylglycine

Roles as Enzyme Ligand

Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
required, essential for the demethylase activity in vivo
-
activates at lower 2-oxoglutarate concentration
-

Inhibitor in Enzyme-catalyzed Reactions (99 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competes with 2-oxoglutarate
-
NOG, selectively inhibits JMJD1A
-
i.e. NOG, a non-reactive 2-oxoglutarate analogue
-
competitive vs. 2-oxoglutarate, uncompetitive vs. NADPH, noncompetitive vs. NH4+
-
competitive inhibition versus saccharopine and uncompetitive inhibition versus NADP+
-

3D Structure of Enzyme-Ligand-Complex (PDB) (43 results)

Enzyme Kinetic Parameters

Ki Value (24 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.29
-
-
0.002
-
pH 7.8, 37C, Ki-value is determined using soluble extracts of cells expressing enzyme-FLAGHis
0.00012
-
pH 7.4, 25C
0.1
-
at pH 7.0

IC50 Value (4 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0000022
-
isoform PHD2, pH and temperature not specified in the publication
0.025
-
-
0.026
-
pH 7.2, 21C
0.067
-
pH and temperature not specified in the publication

References & Links

Links to other databases for N-oxalylglycine

ChEBI
PubChem
ChEBI
PubChem