Ligand a protein with reduced L-cysteine residues
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Basic Ligand Information
a protein with reduced L-cysteine residues
Related pathways
MetaCyc
glutathione-glutaredoxin redox reactions, vitamin K-epoxide cycle
Show all BRENDA pathways known for a protein with reduced L-cysteine residues
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)
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2,3-epoxyphylloquinone + a protein with reduced L-cysteine residues = phylloquinone + a protein with a disulfide bond + H2O
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phylloquinone + a protein with reduced L-cysteine residues = phylloquinol + a protein with a disulfide bond
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Substrate in Enzyme-catalyzed Reactions (2 results)
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2,3-epoxyphylloquinone + a protein with reduced L-cysteine residues = phylloquinone + a protein with a disulfide bond + H2O
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phylloquinone + a protein with reduced L-cysteine residues = phylloquinol + a protein with a disulfide bond
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Enzyme Kinetic Parameters
References & Links
Literature References (4)
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Structural investigation of the vitamin K epoxide reductase (VKORC1) binding site with vitamin K
2020
Chatron, N.; Abi Khalil, R.; Benoit, E.; Lattard, V.
Biochemistry
59
1351-1360
Warfarin and vitamin K epoxide reductase a molecular accounting for observed inhibition
2018
Wu, S.; Chen, X.; Jin, D.Y.; Stafford, D.W.; Pedersen, L.G.; Tie, J.K.
Blood
132
647-657
Characterization of warfarin inhibition kinetics requires stabilization of intramembrane vitamin K epoxide reductases
2020
Li, S.; Liu, S.; Yang, Y.; Li, W.
J. Mol. Biol.
432
5197-5208
A novel vitamin K derived anticoagulant tolerant to genetic variations of vitamin K epoxide reductase
2021
Chen, X.; Liu, Y.; Furukawa, N.; Jin, D.Y.; Paul Savage, G.; Stafford, D.W.; Suhara, Y.; Williams, C.M.; Tie, J.K.
J. Thromb. Haemost.
19
689-700
Links to other databases for a protein with reduced L-cysteine residues