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-
The yeast cadmium factor protein (YCF1) is a vacuolar glutathione S-conjugate pump
1996
Li, Z.S.; Szczypka, M.; Lu, Y.P.; Thiele ,D.J.; Rea, P.A.
J. Biol. Chem.
217
6509-6517
Kinetics of the conversion of leukotriene C by gamma-glutamyl transpeptidase
1982
Ãrning, L.; Hammarström, S.
Biochem. Biophys. Res. Commun.
106
1304-1309
gamma-Glutamyl transpeptidase, a leukotriene metabolizing enzyme
1982
Bernström, K.; Orning, L.; Hammarström, S.
Methods Enzymol.
86
38-45
-
14,15-dehydroleukotriene A4: a specific substrate for leukotriene C4 synthase
1997
Sala, A.; Garcia, M.; Zarini, S.; Rossi, J.C.; Folco, G.; Durand, T.
Biochem. J.
328
225-229
LTC4 synthase: Enzymology, biochemistry, and molecular characterization
1999
Penrose, J.F.
Clin. Rev. Allergy Immunol.
17
133-152
-
The biochemical, molecular, and genomic aspects of leukotriene C4 synthase
1999
Penrose, J.F.; Austen, K.F.
Proc. Assoc. Am. Phys.
111
537-546
Formation of murine macrophage-derived 5-oxo-7-glutathionyl-8,11,14-eicosatrienoic acid (FOG7) is catalyzed by leukotriene C4 synthase
2002
Hevko, J.M.; Murphy, R.C.
J. Biol. Chem.
277
7037-7043
Human mast cells express two leukotriene C4 synthase isoenzymes and the CysLT1 receptor
2002
Sjostrom, M.; Jakobsson, P.J.; Juremalm, M.; Ahmed, A.; Nilsson, G.; Macchia, L.; Haeggstrom, J.Z.
Biochim. Biophys. Acta
1583
53-62
Kinetic mechanism of glutathione conjugation to leukotriene A4 by leukotriene C4 synthase
1998
Gupta, N.; Gresser, M.J.; Ford-Hutchinson, A.W.
Biochim. Biophys. Acta
1391
157-168
Leukotriene C synthase in mouse mastocytoma cells. An enzyme distinct from cytosolic and microsomal glutathione transferases
1988
Söderström, M.; Hammarström, S.; Mannervik, B.
Biochem. J.
250
713-718
Membrane localization and topology of leukotriene C4 synthase
2002
Christmas, P.; Weber, B.M.; McKee, M.; Brown, D.; Soberman, R.J.
J. Biol. Chem.
277
28902-28908
Purification to homogeneity and the N-terminal sequence of human leukotriene C4 synthase: a homodimeric glutathione S-transferase composed of 18-kDa subunits
1993
Nicholson, D.W.; Ali, A.; Vaillancourt, J.P.; Calaycay, J.R.; Mumford, R.A.; Zamboni, R.J.; Ford-Hutchinson, A.W.
Proc. Natl. Acad. Sci. USA
90
2015-2019
Human leukotriene C4 synthase expression in dimethyl sulfoxide-differentiated U937 cells
1992
Nicholson, D.W.; Ali, A.; Klemba, M.W.; Munday, N.A.; Zamboni, R.J.; Ford-Hutchinson, A.W.
J. Biol. Chem.
267
17849-17857
Characterization of leukotriene C4 synthetase in mouse peritoneal exudate cells
1988
Abe, M.; Hugli, T.E.
Biochim. Biophys. Acta
959
386-398
Protein-protein interaction affinity chromatography of leukotriene C4 synthase
1995
Soederstroem, M.; Morgenstern, R.; Hammarstroem, S.
Protein Expr. Purif.
6
352-356
Solubilization and partial purification of leukotriene C4 synthase from guinea-pig lung: a microsomal enzyme with high specificity towards 5,6-epoxide leukotriene A4
1988
Izumi, T.; Honda, Z.; Ohishi, N.; Kitamura, S.; Tsuchida, S.; Sato, K.; Shimizu, T.; Seyama, Y.
Biochim. Biophys. Acta
959
305-315
Two step purification of human and murine leukotriene C4 synthase
1995
Goppelt-Struebe, M.
Biochim. Biophys. Acta
1256
257-261
On the nature of leukotriene C4 synthase in human platelets
1992
Söderström, M.; Mannervik, B.; Garkov, V.; Hammarström, S.
Arch. Biochem. Biophys.
294
70-74
Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes
2002
Lam, B.K.; Frank Austen, K.
Prostaglandins Other Lipid Mediat.
68-69
511-520
Isolation and characterization of leukotriene C4 synthetase of rat basophilic leukemia cells
1985
Yoshimoto, T.; Soberman, R.J.; Lewis, R.A.; Austen, K.F.
Proc. Natl. Acad. Sci. USA
82
8399-8403
Demonstration of leukotriene-C4 synthase in platelets and species distribution of the enzyme activity
1998
Tornhamre, S.; Sjolinder, M.; Lindberg, A.; Ericsson, I.; Nasman-Glaser, B.; Griffiths, W.J.; Lindgren, J.A.
Eur. J. Biochem.
251
227-235
Conversion of leukotrienes A4 to C4 in cell-free systems
1986
Wu, C.
Biochem. Biophys. Res. Commun.
134
85-92
Purification of human leukotriene C4 synthase
1992
Penrose, J.F.; Gagnon, L.; Goppelt-Struebe, M.; Myers, P.; Lam, B.K.; Jack, R.M.; Austen, K.F.; Soberman, R.J.
Proc. Natl. Acad. Sci. USA
89
11603-11606
Purification of human leukotriene C4 synthase from dimethylsulfoxide-differentiated U937 cells
1992
Nicholson, D.W.; Klemba, M.W.; Rasper, D.M.; Metters, K.M.; Zamboni, R.J.
Eur. J. Biochem.
209
725-734
Leukotriene C4 synthase from rat basophilic leukemia cell microsomes
1988
Soberman, R.J.; Yoshimoto, T.
Methods Enzymol.
163
353-357
Purification and properties of leukotriene C4 synthase from guinea pig lung microsomes
1990
Soberman, R.J.
Methods Enzymol.
187
335-337
Leukotriene C4 synthase: characterization in mouse mastocytoma cells
1990
Söderström, M.; Mannervik, B.; Mammarström, S.
Methods Enzymol.
187
306-312
Molecular cloning, expression and characterization of mouse leukotriene C4 synthase
1996
Lam, B.K.; Penrose, J.F.; Rokach, J.; Xu, K.; Baldasaro, M.H.; Austen, K.F.
Eur. J. Biochem.
238
606-612
Solubilization and characterization of the leukotriene C4 synthetase of rat basophil leukemia cells: a novel, particulate glutathione S-transferase
1984
Bach, M.K.; Brashler, J.R.; Morton, D.R.
Arch. Biochem. Biophys.
230
455-465
Renal leukotriene C4 synthase: characterization, partial purification and alterations in experimental glomerulonephritis
1995
Petric, R.; Nicholson, D.W.; Ford-Hutchinson, A.W.
Biochim. Biophys. Acta
1254
207-215
Glutathione, S-substituted glutathiones, and leukotriene C4 as substrates for peptidylglycine alpha-amidating monooxygenase
2003
Miller, L.A.; Baumgart, L.E.; Chew, G.H.; deLong, M.A.; Galloway, L.C.; Jung, K.W.; Merkler, K.A.; Nagle, A.S.; Poore, D.D.; Yoon, C.H.; Merkler, D.J.
Arch. Biochem. Biophys.
412
3-12
Molecular and catalytic properties of three rat leukotriene C4 synthase homologs
2003
Schroder, O.; Sjostrom, M.; Qiu, H.; Stein, J.; Jakobsson, P.J.; Haeggstrom, J.Z.
Biochem. Biophys. Res. Commun.
312
271-276
Leukotriene C4 synthase homo-oligomers detected in living cells by bioluminescence resonance energy transfer
2003
Svartz, J.; Blomgran, R.; Hammarstrom, S.; Soderstrom, M.
Biochim. Biophys. Acta
1633
90-95
Microsomal glutathione S-transferases: selective up-regulation of leukotriene C4 synthase during lipopolysaccharide-induced pyresis
2005
Schroder, O.; Sjostrom, M.; Qiu, H.; Jakobsson, P.J.; Haeggstrom, J.Z.
Cell. Mol. Life Sci.
62
87-94
Leukotriene synthesis is increased by transcriptional up-regulation of 5-lipoxygenase, leukotriene A4 hydrolase, and leukotriene C4 synthase in asthmatic children
2003
Zaitsu, M.; Hamasaki, Y.; Matsuo, M.; Ichimaru, T.; Fujita, I.; Ishii, E.
J. Asthma
40
147-154
Induction of leukotriene C4 synthase after the differentiation of rat basophilic leukemia cells with retinoic acid and a low dose of actinomycin D and its suppression with methylprednisolone
2003
Abe, M.; Shibata, K.; Urata, H.; Sakata, N.; Katsuragi, T.
J. Cell. Physiol.
196
154-164
Inhibition of 5-lipoxygenase and leukotriene C4 synthase in human blood cells by thymoquinone
2004
Mansour, M.; Tornhamre, S.
J. Enzyme Inhib. Med. Chem.
19
431-436
Leukotriene C4 synthase
2003
Lam, B.K.
Prostaglandins Leukot. Essent. Fatty Acids
69
111-116
Human leukotriene C4 synthase at 4.5.ANG. resolution in projection
2004
Schmidt-Krey, I.; Kanaoka, Y.; Mills, D.J.; Irikura, D.; Haase, W.; Lam, B.K.; Austen, K.F.; Kuehlbrandt, W.
Structure
12
2009-2014
Familial aggregation of aspirin-induced urticaria and leukotriene C synthase allelic variant
2006
Mastalerz, L.; Setkowicz, M.; Sanak, M.; Rybarczyk, H.; Szczeklik, A.
Br. J. Dermatol.
154
256-260
Microsomal prostaglandin E2 synthase-1 (mPGES-1): a novel anti-inflammatory therapeutic target
2008
Friesen, R.W.; Mancini, J.A.
J. Med. Chem.
51
4059-4067
Understanding microscopic binding of human microsomal prostaglandin E synthase-1 with substrates and inhibitors by molecular modeling and dynamics simulation
2008
Hamza, A.; Abdulhameed, M.D.; Zhan, C.G.
J. Phys. Chem. B
112
7320-7329
Location, location, location: compartmentalization of early events in leukotriene biosynthesis
2010
Newcomer, M.E.; Gilbert, N.C.
J. Biol. Chem.
285
25109-25114
gamma-Glutamyl leukotrienase cleavage of leukotriene C4
2000
Lieberman, M.; Shields, J.; Will, Y.; Reed, D.; Carter, B.
Adv. Exp. Med. Biol.
469
301-306
gamma-Glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D4 formation in vivo
2002
Han, B.; Luo, G.; Shi, Z.; Barrios, R.; Atwood, D.; Liu, W.; Habib, G.; Sifers, R.; Corry, D.; Lieberman, M.
Am. J. Pathol.
161
481-490
Gamma-glutamyl compounds: Substrate specificity of gamma-glutamyl transpeptidase enzymes
2011
Wickham, S.; West, M.; Cook, P.; Hanigan, M.
Anal. Biochem.
414
208-214
Metabolism of leukotriene C4 in gamma-glutamyl transpeptidase-deficient mice
1997
Carter, B.; Wiseman, A.; Orkiszewski, R.; Ballard, K.; Ou, C.; Lieberman, M.
J. Biol. Chem.
272
12305-12310
gamma-Glutamyl leukotrienase, a gamma-glutamyl transpeptidase gene family member, is expressed primarily in spleen
1998
Carter, B.; Shi, Z.; Barrios, R.; Lieberman, M.
J. Biol. Chem.
273
28277-28285
Disruption of gamma-glutamyl leukotrienase results in disruption of leukotriene D4 synthesis in vivo and attenuation of the acute inflammatory response
2001
Shi, Z.; Han, B.; Habib, G.; Matzuk, M.; Lieberman, M.
Mol. Cell. Biol.
21
5389-5395
ATP-dependent GSH and glutathione S-conjugate transport in skate liver Role of an Mrp functional homologue
2000
Rebbeor, J.; Connolly, G.; Henson, J.; Boyer, J.; Ballatori, N.
Am. J. Physiol.
279
G417-G425
RLIP76 is the major ATP-dependent transporter of glutathione-conjugates and doxorubicin in human erythrocytes
2001
Sharma, R.; Singhal, S.; Cheng, J.; Yang, Y.; Sharma, A.; Zimniak, P.; Awasthi, S.; Awasthi, Y.
Arch. Biochem. Biophys.
391
171-179
Binding of a photoaffinity analogue of glutathione to MRP1 (ABCC1) within two cytoplasmic regions (L0 and L1) as well as transmembrane domains 10-11 and 16-17
2003
Karwatsky, J.; Daoud, R.; Cai, J.; Gros, P.; Georges, E.
Biochemistry
42
3286-3294
ATP- and glutathione-dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1
1999
Renes, J.; De Vries, E.; Nienhuis, E.; Jansen, P.; Mueller, M.
Br. J. Pharmacol.
126
681-688
ATP binding enables substrate release from multidrug resistance protein 1
2018
Johnson, Z.L.; Chen, J.
Cell
172
81-89
ATP-binding cassette exporters structure and mechanism with a focus on P-glycoprotein and MRP1
2017
Arana, M.R.; Altenberg, G.
Curr. Med. Chem.
25
1-17
Integration of hepatic drug transporters and phase II metabolizing enzymes Mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites
2006
Zamek-Gliszczynski, M.; Hoffmaster, K.; Nezasa, K.; Tallman, M.; Brouwer, K.
Eur. J. Pharm. Sci.
27
447-486
Multidrug resistance protein 1 (MRP1, ABCC1), a multitasking ATP-binding cassette (ABC,) transporter
2014
Cole, S.
J. Biol. Chem.
289
30880-30888
Molecular mechanisms of reduced glutathione transport Role of the MRP/CFTR/ABCC and OATP/SLC21A families of membrane proteins
2005
Ballatori, N.; Hammond, C.; Cunningham, J.; Krance, S.; Marchan, R.
Toxicol. Appl. Pharmacol.
204
238-255
Transport of glutathione and glutathione conjugates by MRP1
2006
Cole, S.; Deeley, R.
Trends Pharmacol. Sci.
27
438-446