Ligand (S)-1-hydroxy-N-methylcanadine
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Basic Ligand Information
Molecular Structure

C21H23NO5
(S)-1-hydroxy-N-methylcanadine
FJOUYKHTSXWRMH-UEDXYCIISA-O
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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(S)-1-hydroxy-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2 = (13S,14R)-1,13-dihydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)
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(S)-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2 = (S)-1-hydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O
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Substrate in Enzyme-catalyzed Reactions (2 results)
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(S)-1-hydroxy-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2 = (13S,14R)-1,13-dihydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O
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(S)-1-hydroxy-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2 = ?
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Product in Enzyme-catalyzed Reactions (1 result)
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(S)-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2 = (S)-1-hydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O
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Enzyme Kinetic Parameters
KM Value (2 results)
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References & Links
Literature References (3)
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Acetylation serves as a protective group in noscapine biosynthesis in opium poppy
2015
Dang, T.; Chen, X.; Facchini, P.
Nat. Chem. Biol.
11
104-106
Engineering biosynthesis of the anticancer alkaloid noscapine in yeast
2016
Li, Y.; Smolke, C.
Nat. Commun.
7
12137
Complete biosynthesis of noscapine and halogenated alkaloids in yeast
2018
Li, Y.; Li, S.; Thodey, K.; Trenchard, I.; Cravens, A.; Smolke, C.
Proc. Natl. Acad. Sci. USA
115
E3922-E3931
Links to other databases for (S)-1-hydroxy-N-methylcanadine