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Ligand histone H3 N6,N6,N6-trimethyl-L-lysine27

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Natural Substrate (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.11.68

[histone H3]-N6,N6,N6-trimethyl-L-lysine 27 + 2-oxoglutarate + O2 = [histone H3]-N6,N6-dimethyl-L-lysine 27 + succinate + formaldehyde + CO2

753821

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1.14.18.B1

histone H3 N6,N6,N6-trimethyl-L-lysine27 + 2-oxoglutarate + O2 = histone H3 N6,N6-dimethyl-L-lysine27 + succinate + formaldehyde + CO2

744984, 745509, 745947, 745948

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In Vivo Product in Enzyme-catalyzed Reactions (3 results)

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Show Natural Product (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.356

3 S-adenosyl-L-methionine + a [histone H3]-L-lysine27 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27

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-

2.1.1.356

S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine27 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27

-

-

2.1.1.356

S-adenosyl-L-methionine + [histone H3]-N6,N6-dimethyl-L-lysine27 = S-adenosyl-L-homocysteine + [histone H3]-N6,N6,N6-trimethyl-L-lysine27

-

-

2.1.1.356

3 entries

Substrate in Enzyme-catalyzed Reactions (4 results)

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Show Substrate (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.11.68

a [histone H3]-N6,N6,N6-trimethyl-L-lysine27 + 2 2-oxoglutarate + 2 O2 = a [histone H3]-N6-methyl-L-lysine27 + 2 succinate + 2 formaldehyde + 2 CO2

754878

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1.14.11.68

a [histone H3]-N6,N6,N6-trimethyl-L-lysine27 + 2-oxoglutarate + O2 = a [histone H3]-N6,N6-dimethyl-L-lysine27 + succinate + formaldehyde + CO2

754878

-

1.14.11.68

[histone H3]-N6,N6,N6-trimethyl-L-lysine 27 + 2-oxoglutarate + O2 = [histone H3]-N6,N6-dimethyl-L-lysine 27 + succinate + formaldehyde + CO2

753821

-

1.14.11.68

3 entries

1.14.18.B1

histone H3 N6,N6,N6-trimethyl-L-lysine27 + 2-oxoglutarate + O2 = histone H3 N6,N6-dimethyl-L-lysine27 + succinate + formaldehyde + CO2

744984, 745509, 745947, 745948

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Product in Enzyme-catalyzed Reactions (3 results)

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Show Product (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.356

3 S-adenosyl-L-methionine + a [histone H3]-L-lysine27 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27

-

-

2.1.1.356

S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine27 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27

-

-

2.1.1.356

S-adenosyl-L-methionine + [histone H3]-N6,N6-dimethyl-L-lysine27 = S-adenosyl-L-homocysteine + [histone H3]-N6,N6,N6-trimethyl-L-lysine27

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-

2.1.1.356

3 entries

Activator in Enzyme-catalyzed Reactions (1 result)

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Show Activating Compound (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.356

the basal enzyme activity is stimulated by [histone H3]-N6,N6,N6-trimethyl-L-lysine27

755536

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Enzyme Kinetic Parameters

References & Links

Literature References (7)

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Show Reference (7 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

744984

28348517

Inhibition of H3K27me3 histone demethylase activity prevents the proliferative regeneration of Zebrafish lateral line neuromasts

2017

Bao, B.; He, Y.; Tang, D.; Li, W.; Li, H.

Front. Mol. Neurosci.

10

51

745509

-

Histone H3K27 demethylase JMJD3 in cooperation with NF-kappaB regulates keratinocyte wound healing

2016

Na, J.; Lee, K.; Na, W.; Shin, J.; Lee, M.; Yune, T.; Lee, H.; Jung, H.; Kim, W.; Ju, B.

J. Invest. Dermatol.

136

847-858

745947

-

Long noncoding RNA HOTAIR promotes metastasis of renal cell carcinoma by up-regulating histone H3K27 demethylase JMJD3

2017

Xia, M.; Yao, L.; Zhang, Q.; Wang, F.; Mei, H.; Guo, X.; Huang, W.

Oncotarget

8

19795-19802

745948

-

Histone demethylase JMJD3 regulates CD11a expression through changes in histone H3K27 tri-methylation levels in CD4+ T cells of patients with systemic lupus erythematosus

2017

Yin, H.; Wu, H.; Zhao, M.; Zhang, Q.; Long, H.; Fu, S.; Lu, Q.

Oncotarget

8

48938-48947

753821

29621735

JMJD3 is involved in neutrophil membrane proteinase 3 overexpression during the hyperinflammatory response in early sepsis

2018

Chen, Y.; Liu, Z.; Pan, T.; Chen, E.; Mao, E.; Chen, Y.; Tan, R.; Wang, X.; Tian, R.; Liu, J.; Qu, H.

Int. Immunopharmacol.

59

40-46

754878

17713478

UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development

2007

Agger, K.; Cloos, P.A.; Christensen, J.; Pasini, D.; Rose, S.; Rappsilber, J.; Issaeva, I.; Canaani, E.; Salcini, A.E.; Helin, K.

Nature

449

731-734

755536

26472914

Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2

2015

Jiao, L.; Liu, X.

Science

350

aac4383

Links to other databases for histone H3 N6,N6,N6-trimethyl-L-lysine27

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Show Links (1 entry)