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Ligand [reduced cytochrome P450 reductase]

Basic Ligand Information

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Substrate (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.14.18

protoheme + [reduced cytochrome P450 reductase] + O2 = biliverdin + Fe2+ + CO + [oxidized cytochrome P450 reductase] + H2O

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-

Enzyme Kinetic Parameters

K_M Value (6 results)

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Show KM Value (6 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.14.14.18

0.5

-

wild-type, pH 8.0, 37°C

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1.14.14.18

0.7

-

wild-type, pH 8.0, 37°C

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1.14.14.18

0.9

-

mutant R87A, pH 8.0, 37°C

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1.14.14.18

2.3

-

mutant L201A, pH 8.0, 37°C

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1.14.14.18

15.2

-

mutant K169A, pH 8.0, 37°C

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1.14.14.18

21.7

-

mutant K149A, pH 8.0, 37°C

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1.14.14.18

6 entries

References & Links

Literature References (1)

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Show Reference (1 entry)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

742864

25196843

Protein/protein interactions in the mammalian heme degradation pathway heme oxygenase-2, cytochrome P450 reductase, and biliverdin reductase

2014

Spencer, A.L.; Bagai, I.; Becker, D.F.; Zuiderweg, E.R.; Ragsdale, S.W.

J. Biol. Chem.

289

29836-29858

Links to other databases for [reduced cytochrome P450 reductase]

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