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Ligand succinyl-CoA

Basic Ligand Information

Molecular Structure

Pathway Source

Pathways

BRENDA

4-hydroxymandelate degradation, aerobic toluene degradation, arginine metabolism, citric acid cycle, CO2 fixation in Crenarchaeota, heme metabolism, lysine metabolism, methionine metabolism, methylaspartate cycle, phenylacetate degradation (aerobic), propionate fermentation, toluene degradation more

KEGG

Benzoate degradation, Biosynthesis of alkaloids derived from histidine and purine, Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid, Biosynthesis of alkaloids derived from shikimate pathway, Biosynthesis of alkaloids derived from terpenoid and polyketide, Biosynthesis of phenylpropanoids, Biosynthesis of plant hormones, Biosynthesis of plant secondary metabolites, Biosynthesis of secondary metabolites, Butanoate metabolism, Carbon fixation pathways in prokaryotes, Carbon metabolism, Citrate cycle (TCA cycle), Degradation of aromatic compounds, Glyoxylate and dicarboxylate metabolism, Microbial metabolism in diverse environments, Naphthalene degradation, Phenylalanine metabolism, Propanoate metabolism, Toluene degradation, Valine, leucine and isoleucine degradation more

MetaCyc

(S)-lactate fermentation to propanoate, acetate and hydrogen, 2-amino-3-hydroxycyclopent-2-enone biosynthesis, 2-oxoglutarate decarboxylation to succinyl-CoA, 3-hydroxypropanoate cycle, 3-hydroxypropanoate/4-hydroxybutanate cycle, 3-oxoadipate degradation, 4-methylcatechol degradation (ortho cleavage), acetate formation from acetyl-CoA (succinate), adipate biosynthesis, adipate degradation, alcaligin biosynthesis, anaerobic energy metabolism (invertebrates, mitochondrial), androstenedione degradation I (aerobic), androstenedione degradation II (anaerobic), benzoyl-CoA degradation I (aerobic), bisucaberin biosynthesis, conversion of succinate to propanoate, crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered), desferrioxamine B biosynthesis, desferrioxamine E biosynthesis, incomplete reductive TCA cycle, itaconate degradation, ketolysis, L-arginine degradation II (AST pathway), L-lysine biosynthesis I, L-lysine degradation IV, L-lysine degradation X, L-methionine biosynthesis I, m-xylene degradation (anaerobic), methylaspartate cycle, oxalate degradation II, oxalate degradation III, phenylacetate degradation I (aerobic), propanoyl CoA degradation I, putrebactin biosynthesis, pyruvate fermentation to acetate V, pyruvate fermentation to acetate VI, pyruvate fermentation to propanoate I, reductive TCA cycle I, reductive TCA cycle II, succinate fermentation to butanoate, succinoglycan biosynthesis, TCA cycle I (prokaryotic), TCA cycle II (plants and fungi), TCA cycle III (animals), TCA cycle V (2-oxoglutarate synthase), TCA cycle VI (Helicobacter), TCA cycle VII (acetate-producers), TCA cycle VIII (Chlamydia), tetrapyrrole biosynthesis II (from glycine), toluene degradation to benzoyl-CoA (anaerobic) more

Show all BRENDA pathways known for succinyl-CoA

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (38 results)

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Show Natural Substrate (38 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.2.7.3

succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+ = 2-oxoglutarate + CoA + 2 oxidized ferredoxin

288468, 726403

-

1.2.7.3

succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+ = 2-oxoglutarate + CoA + oxidized ferredoxin

288450, 288466, 711955

-

1.2.7.3

succinyl-CoA + CO2 + reduced ferredoxin = 2-oxoglutarate + CoA + oxidized ferredoxin

288467

-

2.3.1.109

succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine

486124, 486122, 486120, 486123, 486121, 486119, 658725

-

2.3.1.109

succinyl-CoA + L-ornithine = CoA + N2-succinyl-L-ornithine

486120

-

2.3.1.117

succinyl-CoA + (2S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylic acid = CoA + (2S)-2-[(3-carboxypropanoyl)amino]-6-oxoheptanedioic acid

486149, 486150, 486151, 486152, 246566, 486148

1kgt, 3D-view

2.3.1.117

succinyl-CoA + (2S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylic acid = CoA + (2S)-2-[(3-carboxypropanoyl)amino]-6-oxoheptanedioic acid

486149, 486150, 486151, 486152, 246566, 486148

3fsy, 3D-view

2.3.1.117

succinyl-CoA + (2S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylic acid = CoA + (2S)-2-[(3-carboxypropanoyl)amino]-6-oxoheptanedioic acid

486149, 486150, 486151, 486152, 246566, 486148

5e3q, 3D-view

2.3.1.117

succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate

720852

1kgt, 3D-view

2.3.1.117

succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate

720852

3fsy, 3D-view

2.3.1.117

succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate

720852

5e3q, 3D-view

1.2.7.3

3 entries

2.3.1.109

2 entries

2.3.1.117

6 entries

2.3.1.31

succinyl-CoA + L-homoserine = CoA + O-succinyl-L-homoserine

687796

-

2.3.1.37

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

758234, 486858, 757560, 757686, 758299, 756270, 756455, 486860, 756863, 735684, 756091, 757677, 736819, 757255, 735711, 737145, 755944, 756992, 757676, 736116, 736454, 736491, 756100, 758425, 758491, 486809, 486820, 486853, 486854, 486847, 486850, 486824, 486859, 486861, 486818, 486846, 486852, 486808, 486812, 671812

2bwo, 3D-view

2.3.1.46

succinyl-CoA + L-homoserine = CoA + O-succinyl-L-homoserine

487045, 671625, 701784, 735854, 737132, 755666, 757283, 487043, 487046, 671413, 672232

-

2.3.1.61

succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide

487347, 487348, 348914, 349029, 487333, 487337, 487339, 487340, 487345, 487346, 487341, 487344, 487343, 487349, 349039, 349019, 487335, 487336

-

2.3.1.61

succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine

757052, 735580, 755736, 756735, 756495

-

2.3.1.61

2 entries

2.3.1.B34

succinyl-CoA + [AcsA]-L-Lys = CoA + [AcsA]-N6-succinyl-L-Lys

755801

-

2.8.3.13

succinyl-CoA + 3-hydroxy-3-methylglutarate = succinate + 3-hydroxy-3-methylglutaryl-CoA

643832, 643833, 643834

-

2.8.3.15

succinyl-CoA + (R)-2-benzylsuccinate = succinate + (R)-2-benzylsuccinyl-CoA

210661

-

2.8.3.18

succinyl-CoA + acetate = acetyl-CoA + succinate

738287, 721675

-

2.8.3.2

succinyl-CoA + oxalate = succinate + oxalyl-CoA

645964

-

2.8.3.20

succinyl-CoA + (R)-citramalate = succinate + (R)-citramalyl-CoA

674298

-

2.8.3.22

succinyl-CoA + (S)-malate = succinate + (S)-malyl-CoA

725238

-

2.8.3.26

mesaconate + succinyl-CoA = 2-methylfumaryl-CoA + succinate

747846

-

2.8.3.5

succinyl-CoA + 3-hydroxybutyrate = succinate + 3-hydroxybutyryl-CoA

694193

-

2.8.3.5

succinyl-CoA + a 3-oxo acid = succinate + a 3-oxoacyl-CoA

690880, 695186, 672216, 737365, 694193

-

2.8.3.5

succinyl-CoA + acetoacetate = ?

645972, 645971, 645988, 80975, 645984, 645982, 645991, 645992

-

2.8.3.5

succinyl-CoA + acetoacetate = succinate + acetoacetyl-CoA

676985, 663018, 705310, 694193, 660674, 661256, 703810, 705523, 660636, 672216, 724277, 724109, 723826, 676034, 690880, 695186

-

2.8.3.5

succinyl-CoA + beta-hydroxybutyrate = succinate + beta-hydroxybutyryl-CoA

690880, 672216

-

2.8.3.6

3-oxoadipate + succinyl-CoA = 3-oxoadipyl-CoA + succinate

671471

-

2.8.3.6

succinyl-CoA + 3-oxoadipate = ?

646000, 646001, 645997, 645998

-

2.8.3.6

succinyl-CoA + 3-oxoadipate = succinate + 3-oxoadipyl-CoA

738724, 739654, 704325

-

2.8.3.5

5 entries

2.8.3.6

3 entries

3.1.2.3

succinyl-CoA + H2O = ?

81013

-

5.4.99.2

Succinyl-CoA = ?

3504, 3502

4req, 3D-view

6.2.1.4

ADP + phosphate + succinyl-CoA = ATP + succinate + CoA

745246

-

6.2.1.4

GDP + phosphate + succinyl-CoA = GTP + succinate + CoA

745498, 650949

-

6.2.1.5

ADP + phosphate + succinyl-CoA = ?

816, 796, 822

-

6.2.1.5

ADP + phosphate + succinyl-CoA = ATP + succinate + CoA

745498, 762653, 745783, 746481, 650949, 652783, 652784

-

6.2.1.4

2 entries

6.2.1.5

2 entries

In Vivo Product in Enzyme-catalyzed Reactions (18 results)

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Show Natural Product (18 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.2.1.105

2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH

0

-

1.2.1.52

2-oxoglutarate + CoA + NADP+ = succinyl-CoA + CO2 + NADPH

0

-

1.2.7.11

2-oxoglutarate + CoA + oxidized ferredoxin = succinyl-CoA + CO2 + reduced ferredoxin + H+

0

-

1.2.7.3

2-oxoglutarate + CoA + oxidized ferredoxin = succinyl-CoA + CO2 + reduced ferredoxin

0

-

1.2.7.3

2-oxoglutarate + CoA + oxidized ferredoxin = succinyl-CoA + CO2 + reduced ferredoxin + H+

0

-

1.2.7.3

2 entries

2.3.1.174

CoA + 3-oxoadipyl-CoA = succinyl-CoA + acetyl-CoA

0

-

2.3.1.310

(S)-2-benzoylsuccinyl-CoA + CoA = benzoyl-CoA + succinyl-CoA

0

-

2.8.3.1

propionyl-CoA + succinate = propanoate + succinoyl-CoA

0

-

2.8.3.11

succinate + (S)-(+)-citramalyl-CoA = succinyl-CoA + citramalate

645951

-

2.8.3.18

acetyl-CoA + succinate = succinyl-CoA + acetate

0

-

2.8.3.18

succinate + acetyl-CoA = acetate + succinyl-CoA

0

-

2.8.3.18

2 entries

2.8.3.27

propanoyl-CoA + succinate = propanoate + succinyl-CoA

0

-

5.4.99.2

(R)-2-methylmalonyl-CoA = succinyl-CoA

649513, 3514, 649878, 649999, 652093, 652252, 649904, 650005, 652521

4req, 3D-view

5.4.99.2

(R)-methylmalonyl-CoA = succinyl-CoA

0

4req, 3D-view

6.2.1.4

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA

0

-

6.2.1.4

GTP + succinate + CoA = GDP + phosphate + succinyl-CoA

0

-

5.4.99.2

2 entries

6.2.1.4

2 entries

6.2.1.5

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA

0

-

6.4.1.2

ATP + propionyl-CoA + HCO3- + H+ = ADP + succinyl-CoA + phosphate

0

-

Substrate in Enzyme-catalyzed Reactions (133 results)

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Show Substrate (133 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.2.1.75

succinyl-CoA + NADPH + H+ = succinate semialdehyde + coenzyme A + NADP+

698575

-

1.2.1.75

succinyl-CoA + NADPH + H+ = succinic semialdehyde + CoA + NADP+

722819

-

1.2.1.75

2 entries

1.2.1.76

succinyl-CoA + NADPH + H+ = succinate-semialdehyde + coenzyme A + NADP+

697694

-

1.2.7.3

succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+ = 2-oxoglutarate + CoA + 2 oxidized ferredoxin

726403, 763407, 288468, 288457

-

1.2.7.3

succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+ = 2-oxoglutarate + CoA + oxidized ferredoxin

288450, 711955, 288466

-

1.2.7.3

succinyl-CoA + CO2 + reduced ferredoxin = 2-oxoglutarate + CoA + oxidized ferredoxin

288467

-

1.3.8.12

succinyl-CoA + electron-transfer flavoprotein = fumaryl-CoA + reduced electron-transfer flavoprotein

763257

-

1.3.8.12

succinyl-CoA + ferrocenium hexafluorophosphate = fumaryl-CoA + ferricenium hexafluorophosphate

763257

-

2.3.1.109

succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine

486123, 486124, 658725, 486120, 486122, 486121, 486119

-

2.3.1.109

succinyl-CoA + L-homoarginine = CoA + N2-succinyl-L-homoarginine

486122

-

2.3.1.109

succinyl-CoA + L-ornithine = CoA + N2-succinyl-L-ornithine

486120, 486122

-

1.2.7.3

3 entries

1.3.8.12

2 entries

2.3.1.109

3 entries

2.3.1.115

succinyl-CoA + biochanin A-beta-D-glucoside = coenzyme A + biochanin A 7-O-(6-O-succinyl-beta-D-glucoside)

486145

-

2.3.1.116

succinyl-CoA + quercetin 3-O-glucoside = CoA + quercetin 3-(6-O-succinylbeta-D-glucoside)

662666

-

2.3.1.116

succinyl-CoA + quercetin 3-O-glucoside = CoA + quercetin 3-O-(6-O-succinyl-beta-D-glucoside)

662666

-

2.3.1.117

succinyl-CoA + (2S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylic acid = CoA + (2S)-2-[(3-carboxypropanoyl)amino]-6-oxoheptanedioic acid

486149, 486152, 486150, 486151, 486148, 246566

1kgt, 3D-view

2.3.1.117

succinyl-CoA + (2S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylic acid = CoA + (2S)-2-[(3-carboxypropanoyl)amino]-6-oxoheptanedioic acid

486149, 486152, 486150, 486151, 486148, 246566

3fsy, 3D-view

2.3.1.117

succinyl-CoA + (2S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylic acid = CoA + (2S)-2-[(3-carboxypropanoyl)amino]-6-oxoheptanedioic acid

486149, 486152, 486150, 486151, 486148, 246566

5e3q, 3D-view

2.3.1.117

succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate

720852

1kgt, 3D-view

2.3.1.117

succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate

720852

3fsy, 3D-view

2.3.1.117

succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate

720852

5e3q, 3D-view

2.3.1.117

succinyl-CoA + 3,4-dihydro-2H-1,4-thiazine-3,5-dicarboxylic acid = ?

486149

1kgt, 3D-view

2.3.1.117

succinyl-CoA + 3,4-dihydro-2H-1,4-thiazine-3,5-dicarboxylic acid = ?

486149

3fsy, 3D-view

2.3.1.117

succinyl-CoA + 3,4-dihydro-2H-1,4-thiazine-3,5-dicarboxylic acid = ?

486149

5e3q, 3D-view

2.3.1.117

succinyl-CoA + 6-amino-2-hydroxypimelic acid = CoA + N-succinyl-6-amino-2-hydroxypimelate

486149

1kgt, 3D-view

2.3.1.117

succinyl-CoA + 6-amino-2-hydroxypimelic acid = CoA + N-succinyl-6-amino-2-hydroxypimelate

486149

3fsy, 3D-view

2.3.1.117

succinyl-CoA + 6-amino-2-hydroxypimelic acid = CoA + N-succinyl-6-amino-2-hydroxypimelate

486149

5e3q, 3D-view

2.3.1.117

succinyl-CoA + L-2-aminopimelate = CoA + N-succinyl-L-aminopimelate

686773, 486149

1kgt, 3D-view

2.3.1.117

succinyl-CoA + L-2-aminopimelate = CoA + N-succinyl-L-aminopimelate

686773, 486149

3fsy, 3D-view

2.3.1.117

succinyl-CoA + L-2-aminopimelate = CoA + N-succinyl-L-aminopimelate

686773, 486149

5e3q, 3D-view

2.3.1.117

succinyl-CoA + L-6-amino-L-2-hydroxypimelic acid = CoA + N-succinyl-L-6-amino-L-2-hydroxypimelate

486149

1kgt, 3D-view

2.3.1.117

succinyl-CoA + L-6-amino-L-2-hydroxypimelic acid = CoA + N-succinyl-L-6-amino-L-2-hydroxypimelate

486149

3fsy, 3D-view

2.3.1.117

succinyl-CoA + L-6-amino-L-2-hydroxypimelic acid = CoA + N-succinyl-L-6-amino-L-2-hydroxypimelate

486149

5e3q, 3D-view

2.3.1.117

succinyl-CoA + tetrahydrodipicolinate = ?

486148, 486149, 686773

1kgt, 3D-view

2.3.1.117

succinyl-CoA + tetrahydrodipicolinate = ?

486148, 486149, 686773

3fsy, 3D-view

2.3.1.117

succinyl-CoA + tetrahydrodipicolinate = ?

486148, 486149, 686773

5e3q, 3D-view

2.3.1.117

succinyl-CoA + tetrahydrodipicolinate = CoA + (2S)-2-(3-carboxypropanamido)-6-oxoheptanedioate

755963

1kgt, 3D-view

2.3.1.117

succinyl-CoA + tetrahydrodipicolinate = CoA + (2S)-2-(3-carboxypropanamido)-6-oxoheptanedioate

755963

3fsy, 3D-view

2.3.1.117

succinyl-CoA + tetrahydrodipicolinate = CoA + (2S)-2-(3-carboxypropanamido)-6-oxoheptanedioate

755963

5e3q, 3D-view

2.3.1.116

2 entries

2.3.1.117

24 entries

2.3.1.157

succinyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + N-succinyl-alpha-D-glucosamine 1-phosphate

756049

-

2.3.1.171

succinyl-CoA + cyanidin 3-O-beta-D-glucoside = CoA + cyanidin 3-O-(6-O-succinyl-beta-D-glucoside)

657110, 656938

-

2.3.1.171

succinyl-CoA + pelargonidin 3-O-beta-D-glucoside = CoA + pelargonidin 3-O-(6-O-succinyl-beta-D-glucoside)

657110, 656963, 656933

-

2.3.1.171

2 entries

2.3.1.172

succinyl-CoA + shisonin = CoA + succinylshisonin

656032

-

2.3.1.31

succinyl-CoA + L-homoserine = CoA + O-succinyl-L-homoserine

673497, 486788, 687796

-

2.3.1.310

benzoyl-CoA + succinyl-CoA = (S)-2-benzoylsuccinyl-CoA + CoA

764661

-

2.3.1.37

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

486814, 486818, 486832, 486836, 486853, 486843, 486810, 486824, 486846, 486847, 486849, 486850, 486851, 486852, 486855, 486856, 486857, 486859, 486861, 663337, 704690, 706627, 718696, 677263, 719861, 486808, 719419, 758234, 486813, 486822, 486823, 486833, 486834, 486837, 486838, 486841, 486848, 486858, 757560, 486835, 486854, 486827, 486825, 486826, 486828, 486829, 486830, 486831, 486839, 486842, 486844, 486845, 757686, 758299, 486809, 756270, 756455, 486860, 720074, 486817, 486840, 486816, 486820, 756863, 661787, 735684, 756091, 757677, 736819, 757255, 735711, 737145, 755944, 756992, 757676, 736116, 736454, 736491, 756100, 758425, 758491, 486812, 486811, 486819, 486815, 486821, 671812, 671583, 687586

2bwo, 3D-view

2.3.1.37

succinyl-CoA + L-serine = ?

736454

2bwo, 3D-view

2.3.1.37

succinyl-CoA + O-methylglycine = ?

736454

2bwo, 3D-view

2.3.1.37

3 entries

2.3.1.39

succinyl-CoA + an [acyl-carrier protein] = CoA + succinyl-[acyl carrier protein]

755871

-

2.3.1.46

succinyl-CoA + D-homoserine = CoA + O-succinyl-D-homoserine

487046

-

2.3.1.46

succinyl-CoA + L-homoserine = CoA + O-succinyl-L-homoserine

487045, 487043, 487044, 671413, 671625, 672232, 701784, 487046, 735854, 737132, 755666, 757283

-

2.3.1.46

2 entries

2.3.1.5

succinyl-CoA + 5-aminosalicylate = CoA + N-succinyl-5-aminosalicylate

758541

-

2.3.1.61

succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide

487347, 487348, 348914, 349029, 487333, 487337, 487339, 487340, 487345, 487346, 487341, 487344, 487336, 487343, 487349, 349039, 349019, 487335

-

2.3.1.61

succinyl-CoA + dihydrolipoic acid = CoA + succinyldihydrolipoate

487336

-

2.3.1.61

succinyl-CoA + dihydrolipoyllysine = CoA + succinyldihydrolipoyllysine

487336

-

2.3.1.61

succinyl-CoA + DL-dihydrolipoamide = CoA + S-succinyldihydrolipoamide

755867

-

2.3.1.61

succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine

757052, 735580, 755736, 756735, 756495

-

2.3.1.61

5 entries

2.3.1.85

succinyl-CoA + an [acyl-carrier protein] = CoA + succinyl-[acyl-carrier protein]

755686

-

2.3.1.B34

succinyl-CoA + [AcsA]-L-Lys = CoA + [AcsA]-N6-succinyl-L-Lys

755801

-

2.8.3.1

succinyl-CoA + propanoate = ?

737535

-

2.8.3.13

succinyl-CoA + 3-hydroxy-3-methylglutarate = succinate + 3-hydroxy-3-methylglutaryl-CoA

643832, 643833, 643834

-

2.8.3.13

succinyl-CoA + adipate = succinate + adipyl-CoA

643834

-

2.8.3.13

succinyl-CoA + glutarate = succinate + glutaryl-CoA

643834

-

2.8.3.13

succinyl-CoA + malonate = succinate + malonyl-CoA

643834

-

2.8.3.13

succinyl-CoA + methylmalonate = succinate + methylmalonyl-CoA

643834

-

2.8.3.15

succinyl-CoA + (R)-2-benzylsuccinate = succinate + (R)-2-benzylsuccinyl-CoA

210661, 637247

-

2.8.3.15

succinyl-CoA + (R)-benzylsuccinate = succinate + (R)-benzylsuccinyl-CoA

738119

-

2.8.3.15

succinyl-CoA + (R,S)-benzylsuccinate = succinate + (R,S)-benzylsuccinyl-CoA

738119

-

2.8.3.15

succinyl-CoA + (R,S)-phenylsuccinate = succinate + 2-phenylsuccinyl-CoA + 3-phenylsuccinyl-CoA

738119

-

2.8.3.15

succinyl-CoA + (S)-benzylsuccinate = succinate + (S)-benzylsuccinyl-CoA

738119

-

2.8.3.15

succinyl-CoA + 2-oxoindole-3-acetate = succinate + 2-oxoindole-3-acetyl-CoA

738119

-

2.8.3.15

succinyl-CoA + benzylmalonate = succinate + benzylmalonyl-CoA

637247

-

2.8.3.15

succinyl-CoA + indole-3-acetate = succinate + indole-3-acetyl-CoA

738119

-

2.8.3.15

succinyl-CoA + methylsuccinate = succinate + methylsuccinyl-CoA

637247

-

2.8.3.15

succinyl-CoA + phenylsuccinate = succinate + phenylsuccinyl-CoA

637247

-

2.8.3.13

5 entries

2.8.3.15

10 entries

2.8.3.16

succinyl-CoA + oxalate = succinate + oxalyl-CoA

645963, 645961, 645959

-

2.8.3.18

acetate + succinyl-CoA = succinate + acetyl-CoA

692865

-

2.8.3.18

acetoacetate + succinyl-CoA = succinate + acetoacetyl-CoA

692865

-

2.8.3.18

succinyl-CoA + acetate = acetyl-CoA + succinate

738287, 692865, 721675

-

2.8.3.18

succinyl-CoA + acetoacetate = acetoacetyl-CoA + succinate

721675, 692865

-

2.8.3.18

succinyl-CoA + D-malate = D-malyl-CoA + succinate

721675

-

2.8.3.18

succinyl-CoA + DL-methylsuccinate = DL-methylsuccinyl-CoA + succinate

721675

-

2.8.3.18

succinyl-CoA + formate = formyl-CoA + succinate

721675

-

2.8.3.18

succinyl-CoA + fumarate = fumaryl-CoA + succinate

721675

-

2.8.3.18

succinyl-CoA + glutarate = glutaryl-CoA + succinate

721675

-

2.8.3.18

succinyl-CoA + L-malate = L-malyl-CoA + succinate

721675

-

2.8.3.18

succinyl-CoA + oxaloacetate = oxaloacetyl-CoA + succinate

721675

-

2.8.3.18

succinyl-CoA + propionate = propionyl-CoA + succinate

721675

-

2.8.3.18

12 entries

2.8.3.2

succinyl-CoA + oxalate = succinate + oxalyl-CoA

645964

-

2.8.3.20

succinyl-CoA + (R)-citramalate = succinate + (R)-citramalyl-CoA

674298

-

2.8.3.20

succinyl-CoA + (R)-malate = succinate + (R)-malyl-CoA

674298

-

2.8.3.20

succinyl-CoA + itaconate = succinate + ?

674298

-

2.8.3.22

succinyl-CoA + (S)-citramalate = succinate + (S)-citramalyl-CoA

725238

-

2.8.3.22

succinyl-CoA + (S)-malate = succinate + (S)-malyl-CoA

725238

-

2.8.3.22

succinyl-CoA + itaconate = succinate + ?

725238

-

2.8.3.26

acrylate + succinyl-CoA = ? + succinate

747846

-

2.8.3.26

glutarate + succinyl-CoA = ? + succinate

747846

-

2.8.3.26

itaconate + succinyl-CoA = ? + succinate

747846

-

2.8.3.26

mesaconate + succinyl-CoA = 2-methylfumaryl-CoA + succinate

747846

-

2.8.3.26

methylsuccinate + succinyl-CoA = ? + succinate

747846

-

2.8.3.27

acetate + succinyl-CoA = acetyl-CoA + succinate

765011

-

2.8.3.27

propanoate + succinyl-CoA = propanoyl-CoA + succinate

765011, 765332

-

2.8.3.28

(R)-benzylsuccinate + succinyl-CoA = (R)-2-benzylsuccinyl-CoA + succinate

764580

-

2.8.3.28

(R/S)-benzylsuccinate + succinyl-CoA = (R/S)-2-benzylsuccinyl-CoA + succinate

764580

-

2.8.3.28

(R/S)-phenylsuccinate + succinyl-CoA = (R/S)-2-phenylsuccinyl-CoA + (R/S)-3-phenylsuccinyl-CoA + succinate

764580

-

2.8.3.28

(S)-benzylsuccinate + succinyl-CoA = (S)-2-benzylsuccinyl-CoA + succinate

764580

-

2.8.3.28

2'-(2-aminophenyl)succinate + succinyl-CoA = 3'-(2-aminophenyl)succinyl-CoA + succinate

764580

-

2.8.3.28

2-oxoindole-3-acetate + succinyl-CoA = 2-oxoindole-3-acetyl-CoA + succinate

764580

-

2.8.3.28

indole-3-acetate + succinyl-CoA = indole-3-acetyl-CoA + succinate

764580

-

2.8.3.5

succinyl-CoA + 3-hydroxybutyrate = succinate + 3-hydroxybutyryl-CoA

694193

-

2.8.3.5

succinyl-CoA + a 3-oxo acid = succinate + a 3-oxoacyl-CoA

694193, 690880, 695186, 762068, 672216, 737365

-

2.8.3.5

succinyl-CoA + acetoacetate = ?

645972, 645971, 645988, 80975, 645984, 645982, 645991, 645992

-

2.8.3.5

succinyl-CoA + acetoacetate = succinate + acetoacetyl-CoA

80975, 676985, 645977, 645991, 645992, 663018, 705310, 724424, 676034, 694193, 645974, 645975, 645976, 645987, 645994, 660674, 661256, 703810, 705523, 645972, 645973, 645978, 645971, 645988, 645995, 660636, 645967, 645969, 645970, 645979, 645986, 672216, 645980, 645983, 695186, 738807, 724277, 724109, 737420, 645968, 723826, 690880

-

2.8.3.5

succinyl-CoA + beta-hydroxybutyrate = succinate + beta-hydroxybutyryl-CoA

690880, 672216

-

2.8.3.5

succinyl-CoA + maleate = succinate + maleyl-CoA

645978

-

2.8.3.6

3-oxoadipate + succinyl-CoA = 3-oxoadipyl-CoA + succinate

671471

-

2.8.3.6

succinyl-CoA + 2-oxoadipate = succinate + 2-oxoadipyl-CoA

646002

-

2.8.3.6

succinyl-CoA + 3-oxoadipate = ?

646000, 646001, 645997, 645998

-

2.8.3.6

succinyl-CoA + 3-oxoadipate = succinate + 3-oxoadipyl-CoA

645996, 94277, 645997, 645998, 646000, 738724, 739654, 646002, 704325

-

2.8.3.6

succinyl-CoA + 3-oxoglutarate = succinate + 3-oxoglutaryl-CoA

646002

-

2.8.3.6

succinyl-CoA + 4-methyl-3-oxoadipate = succinate + 4-methyl-3-oxoadipyl-CoA

646002

-

2.8.3.20

3 entries

2.8.3.22

3 entries

2.8.3.26

5 entries

2.8.3.27

2 entries

2.8.3.28

7 entries

2.8.3.5

6 entries

2.8.3.6

6 entries

2.8.3.8

acetate + succinyl-CoA = succinate + acetyl-CoA

721675

-

3.1.2.1

succinyl-CoA = succinate + CoA

94468, 94470, 94488

-

3.1.2.2

succinyl-CoA + H2O = CoA + succinate

646180

-

3.1.2.20

succinyl-CoA + H2O = CoA + succinate

690932, 679724, 646180

-

3.1.2.3

succinyl CoA + H2O = CoA + succinate

665676, 81013

-

3.1.2.3

succinyl-CoA + H2O = ?

81013

-

3.1.2.3

2 entries

5.4.99.2

Succinyl-CoA = ?

3504, 3502

4req, 3D-view

6.2.1.13

ADP + phosphate + succinyl-CoA = ATP + succinate + CoA

626, 624

-

6.2.1.4

ADP + phosphate + succinyl-CoA = ATP + succinate + CoA

745246

-

6.2.1.4

GDP + phosphate + succinyl-CoA = GTP + succinate + CoA

745498, 650949

-

6.2.1.5

ADP + phosphate + succinyl-CoA = ?

816, 796, 822

-

6.2.1.5

ADP + phosphate + succinyl-CoA = ATP + succinate + CoA

801, 745498, 762653, 745783, 746481, 650949, 652783, 652784

-

6.2.1.4

2 entries

6.2.1.5

2 entries

6.4.1.3

ATP + succinyl-CoA + HCO3- = ADP + phosphate + ?

649502

-

Product in Enzyme-catalyzed Reactions (51 results)

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Show Product (51 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.2.1.105

2-oxoglutarate + CoA + 3-acetylpyridine adenine dinucleotide = succinyl-CoA + CO2 + reduced 3-acetylpyridine adenine dinucleotide

0

-

1.2.1.105

2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH

0

-

1.2.1.105

2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH + H+

0

-

1.2.1.105

3 entries

1.2.1.52

2-oxoglutarate + CoA + NADP+ = succinyl-CoA + CO2 + NADPH

0

-

1.2.1.75

succinate semialdehyde + coenzyme A + NADP+ = succinyl-CoA + NADPH + H+

0

-

1.2.1.76

succinate-semialdehyde + coenzyme A + NADP+ = succinyl-CoA + NADPH + H+

0

-

1.2.7.11

2-oxoglutarate + CoA + oxidized methyl viologen = succinoyl-CoA + CO2 + reduced methyl viologen

0

-

1.2.7.11

2-oxoglutarate + CoA + 2 oxidized cytochrome c = succinyl-CoA + CO2 + 2 reduced cytochrome c + 2 H+

0

-

1.2.7.11

2-oxoglutarate + CoA + 2 oxidized ferredoxin = succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+

0

-

1.2.7.11

2-oxoglutarate + CoA + 2 oxidized methyl viologen = succinyl-CoA + CO2 + 2 reduced methyl viologen + 2 H+

0

-

1.2.7.11

2-oxoglutarate + CoA + oxidized ferredoxin = succinyl-CoA + CO2 + reduced ferredoxin + H+

0

-

1.2.7.11

2-oxoglutarate + CoA + oxidized methyl viologen = succinyl-CoA + CO2 + reduced methyl viologen + H+

0

-

1.2.7.3

2-oxoglutarate + CoA + 2 oxidized ferredoxin = succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+

0

-

1.2.7.3

2-oxoglutarate + CoA + oxidized ferredoxin = succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+

0

-

1.2.7.3

2-oxoglutarate + CoA + oxidized ferredoxin = succinyl-CoA + CO2 + reduced ferredoxin

0

-

1.2.7.3

2-oxoglutarate + CoA + oxidized ferredoxin = succinyl-CoA + CO2 + reduced ferredoxin + H+

0

-

1.2.7.3

2-oxoglutarate + CoA + oxidized methyl viologen = succinyl-CoA + CO2 + reduced methyl viologen

0

-

2.3.1.174

CoA + 3-oxoadipyl-CoA = succinyl-CoA + acetyl-CoA

0

-

2.3.1.174

CoA + oxoadipyl-CoA = succinyl-CoA + acetyl-CoA

0

-

1.2.7.11

6 entries

1.2.7.3

5 entries

2.3.1.174

2 entries

2.3.1.310

(S)-2-benzoylsuccinyl-CoA + CoA = benzoyl-CoA + succinyl-CoA

0

-

2.8.3.1

acetyl-CoA + succinate = acetate + succinoyl-CoA

0

-

2.8.3.1

propionyl-CoA + succinate = propanoate + succinoyl-CoA

0

-

2.8.3.1

succinate + acetyl-CoA = acetate + succinyl-CoA

0

-

2.8.3.11

succinate + (3S)-citramalyl-CoA = succinyl-CoA + citramalate

645951

-

2.8.3.11

succinate + (S)-(+)-citramalyl-CoA = succinyl-CoA + citramalate

645951

-

2.8.3.13

3-hydroxy-3-methylglutaryl-CoA + succinate = 3-hydroxy-3-methylglutarate + succinyl-CoA

643834, 0

-

2.8.3.13

adipyl-CoA + succinate = adipate + succinyl-CoA

643834

-

2.8.3.13

glutaryl-CoA + succinate = glutarate + succinyl-CoA

643834

-

2.8.3.13

malonyl-CoA + succinate = malonate + succinyl-CoA

643834

-

2.8.3.13

methylmalonyl-CoA + succinate = methylmalonate + succinyl-CoA

643834

-

2.8.3.18

acetyl-CoA + succinate = succinyl-CoA + acetate

0

-

2.8.3.18

succinate + acetyl-CoA = acetate + succinyl-CoA

0

-

2.8.3.27

acetyl-CoA + succinate = acetate + succinyl-CoA

0

-

2.8.3.27

propanoyl-CoA + succinate = propanoate + succinyl-CoA

0

-

2.8.3.1

3 entries

2.8.3.11

2 entries

2.8.3.13

5 entries

2.8.3.18

2 entries

2.8.3.27

2 entries

2.8.3.8

succinate + acetyl-CoA = acetate + succinyl-CoA

0

-

5.4.99.2

(R)-2-methylmalonyl-CoA = succinyl-CoA

3502, 649513, 3494, 0, 3500, 3503, 3508, 3509, 3513, 3518, 3497, 3409, 3495, 3498, 3501, 3506, 3507, 3510, 3511, 3512, 3514, 3515, 3516, 3517, 649878, 649999, 652093, 652252, 649904, 650005, 3496, 3504, 652521, 3505

4req, 3D-view

5.4.99.2

(R)-methylmalonyl-CoA = succinyl-CoA

0

4req, 3D-view

5.4.99.2

(R/S)-2-methyl-3-oxopropanoyl-CoA = succinyl-CoA

0

4req, 3D-view

5.4.99.2

(S)-methylmalonyl-CoA = succinyl-CoA

0

4req, 3D-view

5.4.99.2

methylmalonyl-CoA = succinyl-CoA

0

4req, 3D-view

5.4.99.2

5 entries

5.4.99.63

(R)-2-methylmalonyl-CoA = succinyl-CoA

0

-

5.4.99.64

methylmalonyl-CoA = succinyl-CoA

0

-

6.2.1.13

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA

0

-

6.2.1.4

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA

0

-

6.2.1.4

GTP + succinate + CoA = GDP + phosphate + succinyl-CoA

0, 783, 650949, 652820, 784, 651897, 788

-

6.2.1.5

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA

0, 649952, 650949, 651897, 650157

-

6.2.1.5

GTP + succinate + CoA = GDP + phosphate + succinyl-CoA

0, 650157, 649952

-

6.2.1.5

UTP + succinate + CoA = ADP + phosphate + succinyl-CoA

0

-

6.2.1.4

2 entries

6.2.1.5

3 entries

6.2.1.9

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA

853, 0

-

6.2.1.B11

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA

0

-

6.4.1.2

ATP + propionyl-CoA + HCO3- + H+ = ADP + succinyl-CoA + phosphate

0

-

Enzyme Cofactor/Cosubstrate (7 results)

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Show Cofactor (7 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.109

-

658725

-

2.3.1.117

-

720852

1kgt, 3D-view

2.3.1.117

-

720852

3fsy, 3D-view

2.3.1.117

-

720852

5e3q, 3D-view

2.3.1.117

3 entries

2.3.1.46

-

735854, 737132

-

2.3.1.B34

-

755801

-

2.8.3.5

-

705310, 703810, 705523

-

Activator in Enzyme-catalyzed Reactions (2 results)

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Show Activating Compound (2 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.3.5.1

activation

391082

-

4.1.1.31

activates

4337

-

Inhibitor in Enzyme-catalyzed Reactions (28 results)

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Show Inhibitors (28 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.2.1.105

-

349002, 349024

-

1.2.1.105

2-oxoglutarate dehydrogenase complex

349018

-

1.2.1.105

2 entries

2.3.1.1

about 60% residual activity at 2.5 mM

735706

-

2.3.1.21

partial proteolysis of CPT I slightly diminishes the inhibitory effect

486572

-

2.3.1.37

non-specific isoform ALAS-N in absence of ATP

486848

2bwo, 3D-view

2.3.1.39

inhibition of MCT2 at 0.02 mM and inhibition of both isozymes at 0.1 mM

486887

-

2.3.1.5

0.1 mM, 96% inhibition

657884

-

2.3.3.10

-

488104

-

2.3.3.10

mitochondrial synthase, 50% inhibition

488099

-

2.3.3.10

2 entries

2.3.3.16

mixed-type inhibition

488059

-

2.7.1.33

-

641393

-

2.8.3.5

-

645967

-

2.8.3.5

product inhibition

645980, 672216

-

2.8.3.5

2 entries

3.1.2.17

competitive inhibition

643853

-

3.1.3.16

-

134616

-

4.1.1.9

-

4846, 4852, 4854, 4856

-

4.1.3.36

-

748290

-

4.2.1.149

0.1 mM, 22% inhibition

724139

-

5.1.99.1

-

2434

-

5.4.99.2

-

3516, 3517

4req, 3D-view

6.2.1.9

product inhibitor

855

-

6.3.4.21

at 1 mM 53% inhibition of activity (concentrations of substrates 1 mM)

721763

-

6.4.1.2

-

651169

-

6.4.1.2

0.5 mM, 84% inhibition of acetyl-CoA carboxylase

725234

-

6.4.1.2

57% inhibition at 0.5 mM; 84% inhibition at 0.5 mM

745205

-

6.4.1.3

0.5 mM, 57% inhibition of propionyl-CoA carboxylase

725234

-

6.4.1.3

activity on propanoyl-CoA is more strongly inhibited than activity of acetyl-CoA

651169

-

6.4.1.2

3 entries

6.4.1.3

2 entries

7.2.4.3

-

4548

-

3D Structure of Enzyme-Ligand-Complex (PDB) (32 results)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (32 entries)

EC NUMBER

ENZYME 3D STRUCTURE

2.3.1.117

1kgt, 3D-view

2.3.1.117

3fsy, 3D-view

2.3.1.117

5e3q, 3D-view

2.3.1.117

1kgt, 3D-view

2.3.1.117

3fsy, 3D-view

2.3.1.117

5e3q, 3D-view

2.3.1.117

1kgt, 3D-view

2.3.1.117

3fsy, 3D-view

2.3.1.117

5e3q, 3D-view

2.3.1.117

1kgt, 3D-view

2.3.1.117

3fsy, 3D-view

2.3.1.117

5e3q, 3D-view

2.3.1.117

1kgt, 3D-view

2.3.1.117

3fsy, 3D-view

2.3.1.117

5e3q, 3D-view

2.3.1.117

1kgt, 3D-view

2.3.1.117

3fsy, 3D-view

2.3.1.117

5e3q, 3D-view

2.3.1.117

18 entries

2.3.1.37

2bwo, 3D-view

2.3.1.48

5trl, 3D-view

2.3.1.48

7d0s, 3D-view

2.3.1.48

5trl, 3D-view

2.3.1.48

7d0s, 3D-view

2.3.1.48

5trl, 3D-view

2.3.1.48

7d0s, 3D-view

2.3.1.48

5trl, 3D-view

2.3.1.48

7d0s, 3D-view

2.3.1.48

5trl, 3D-view

2.3.1.48

7d0s, 3D-view

2.3.1.48

5trl, 3D-view

2.3.1.48

7d0s, 3D-view

2.3.1.48

12 entries

5.4.99.2

4req, 3D-view

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (85 results)

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Show Turnover Number (85 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

1.2.7.3

0.45

-

wild-type, pH 7.0, temperature not specified in the publication

763407

1.3.8.12

0.3

-

mutant enzyme A282V, at pH 7.5 and 30°C

763257

1.3.8.12

0.3

-

recombinant mutant A282V, pH 7.5, 30°C

763257

1.3.8.12

0.32

-

recombinant wild-type enzyme, pH 7.5, 30°C

763257

1.3.8.12

0.32

-

wild type enzyme, at pH 7.5 and 30°C

763257

1.3.8.12

4 entries

2.3.1.117

0.22

-

pH 7.5, 25°C

755963

2.3.1.157

0.9

-

pH 7.5, 30°C

756049

2.3.1.31

0.19

-

25°C, pH 7.5

673497

2.3.1.31

0.803

-

E111G, 50 mM potassium phosphate buffer, pH 7.5, 2 mM L-homoserine, 25°C

687796

2.3.1.37

0.002

-

mutant R85L/T430V, pH 7.5, 30°C

706627

2.3.1.37

0.0095

-

-

486824, 486853

2.3.1.37

0.016

-

mutant R85L, pH 7.5, 30°C

706627

2.3.1.37

0.0183

-

recombinant erythroid isoform mutant G142C

486851

2.3.1.37

0.0355

-

recombinant erythroid isoform mutant Y121H

486855

2.3.1.37

0.04

-

mutant N150H, pH 7.5, 18°C

736491

2.3.1.37

0.06

-

mutant N150F, pH 7.5, 18°C

736491

2.3.1.37

0.0633

-

recombinant erythroid isoform mutant G144T

486851

2.3.1.37

0.09

-

mutant N150W, pH 7.5, 18°C

736491

2.3.1.37

0.0967

-

recombinant erythroid isoform mutant D279E

486856

2.3.1.37

0.107

-

mutant R85K, pH 7.5, 30°C

706627

2.3.1.37

0.12

-

recombinant erythroid isoform mutant G144S

486851

2.3.1.37

0.13

-

mutant N150A, pH 7.5, 18°C

736491

2.3.1.37

0.132

-

recombinant erythroid isoform mutant G144A

486851

2.3.1.37

0.15

-

mutant N150G, pH 7.5, 18°C

736491

2.3.1.37

0.16

-

wild-type enzyme, pH 7.5, 18°C

736491

2.3.1.37

0.167

-

recombinant erythroid isoform

486856

2.3.1.37

0.167

-

wild-type, pH 7.5, 30°C

706627

2.3.1.37

0.17

-

pH 7.5, 37°C, mutant K221V

736116

2.3.1.37

0.235

-

recombinant erythroid isoform mutant Y121F

486855

2.3.1.37

0.25

-

pH 7.5, 37°C, wild-type enzyme

736116

2.3.1.37

0.308

-

recombinant erythroid isoform

486851

2.3.1.37

0.508

-

recombinant erythroid mutant R439K

486857

2.3.1.37

0.658

-

recombinant erythroid isoform

486855, 486857

2.3.1.37

0.842

-

recombinant erythroid mutant R433L

486857

2.3.1.37

1.01

-

isoform HemT, pH and temperature not specified in the publication

757686

2.3.1.37

1.06

-

isoform HemA, pH and temperature not specified in the publication

757686

2.3.1.37

1.1

-

isoform HemA, pH and temperature not specified in the publication

757686

2.3.1.37

1.3

-

isoform HemA, pH and temperature not specified in the publication

757686

2.3.1.37

1.35

-

recombinant erythroid mutant R433K

486857

2.3.1.37

1.61

-

mutant enzyme H340A, at pH 7.5 and 25°C

758425

2.3.1.37

1.69

-

mutant enzyme C398A, at pH 7.5 and 25°C

758425

2.3.1.37

1.73

-

wild type enzyme, at pH 7.5 and 25°C

758425

2.3.1.37

1.79

-

mutant enzyme H340A/C398A, at pH 7.5 and 25°C

758425

2.3.1.37

2.74

-

wild type enzyme, at pH 7.5 and 37°C

756270

2.3.1.37

3.1

-

mutant enzyme H15K, at pH 7.5 and 37°C

756270

2.3.1.37

3.2

-

mutant enzyme H29R, at pH 7.5 and 37°C

756270

2.3.1.37

55.48

-

mutant C281P of isoform HemT, pH and temperature not specified in the publication

757686

2.3.1.46

0.34

-

pH 7.2, 25°C, recombinant mutant K47A

672232

2.3.1.46

0.8

-

pH 7.5, 25°C, recombinant mutant E237A

671625

2.3.1.46

1.2

-

pH 7.5, 25°C, recombinant mutant R193A/E246A

671625

2.3.1.46

1.26

-

pH 7.5, 25°C, recombinant mutant K46L

671625

2.3.1.46

1.8

-

pH 7.2, 25°C, recombinant mutant K47R

672232

2.3.1.46

2

-

pH 7.2, 25°C, recombinant mutant K46R/K47R

672232

2.3.1.46

2

3.7

pH 7.5, 25°C, recombinant mutant R249K

671625

2.3.1.46

3.3

-

pH 7.5, 25°C, recombinant mutant R193A

671625

2.3.1.46

3.4

-

pH 7.5, 25°C, recombinant mutant R193K

671625

2.3.1.46

4.1

-

pH 7.2, 25°C, recombinant mutant K46A

672232

2.3.1.46

6.7

-

pH 7.5, 25°C, recombinant mutant E237D

671625

2.3.1.46

6.9

-

pH 7.5, 25°C, recombinant mutant E246A

671625

2.3.1.46

8.9

-

pH 7.5, 25°C, recombinant mutant Y238F/E246A

671625

2.3.1.46

10

-

pH 7.5, 25°C, recombinant mutant R249A

671625

2.3.1.46

13

-

pH 7.5, 25°C, recombinant mutant Y238F

671625

2.3.1.46

15

-

pH 7.5, 25°C, recombinant mutant E246D

671625

2.3.1.46

24

-

recombinant protein

487046

2.3.1.46

25.7

-

pH 7.5, 25°C, recombinant wild-type enzyme

671625

2.3.1.46

36.72

-

recombinant His-tagged wild-type enzyme, pH and temperature not specified in the publication

735854

2.3.1.46

37

-

pH 7.2, 25°C, recombinant mutant K46R

672232

2.3.1.46

38.59

-

recombinant His-tagged mutant I124L, pH and temperature not specified in the publication

735854

2.3.1.46

39.28

-

recombinant His-tagged mutant I229Y, pH and temperature not specified in the publication

735854

2.3.1.46

40.1

-

pH 7.5, 25°C, recombinant mutant K45L

671625

2.3.1.46

130

-

pH 7.2, 25°C, recombinant mutant C90S

672232

2.3.1.46

130

-

pH 7.2, 25°C, recombinant wild-type enzyme

672232

2.3.1.31

2 entries

2.3.1.37

38 entries

2.3.1.46

25 entries

2.3.1.85

13.4

-

didomain construct, pH not specified in the publication, 25°C

755686

2.8.3.18

201

-

-

692865

2.8.3.18

201

-

pH 8.0, 25°C

692865

2.8.3.18

2 entries

2.8.3.20

13

-

55°C, pH and temperature not specified in the publication

674298

2.8.3.22

11.4

-

55°C, pH not specified in the publication, recombinant enzyme

725238

2.8.3.26

12.2

-

37°C, pH 7.8

747846

2.8.3.5

37.3

-

pH 8.1

645967

3.1.2.20

190

-

pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay

690932

5.4.99.2

0.038

-

25°C, mutant H244A

650005

5.4.99.2

0.66

-

25°C, mutant H244Q

650005

5.4.99.2

6.08

-

25°C, mutant H244Q

650005

5.4.99.2

48

-

25°C, wild-type

650005

5.4.99.2

4 entries

6.2.1.5

201

-

pH 8.0, 25°C

692865

K_M Value (157 results)

top print hide

Show KM Value (157 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.2.1.76

3.2

-

pH 7.0, 30°C

697694

1.2.7.3

0.25

-

pH and temperature not specified in the publication

288457

1.2.7.3

32

-

wild-type, pH 7.0, temperature not specified in the publication

763407

1.3.8.12

0.057

-

mutant enzyme A282V, at pH 7.5 and 30°C

763257

1.3.8.12

0.057

-

recombinant mutant A282V, pH 7.5, 30°C

763257

1.3.8.12

0.141

-

recombinant wild-type enzyme, pH 7.5, 30°C

763257

1.3.8.12

0.141

-

wild type enzyme, at pH 7.5 and 30°C

763257

1.2.7.3

2 entries

1.3.8.12

4 entries

2.3.1.109

0.04

-

-

486119

2.3.1.115

0.101

-

-

486145

2.3.1.117

0.015

-

-

486148

2.3.1.117

0.11

-

pH 7.5, 25°C

755963

2.3.1.117

2 entries

2.3.1.157

1.1

-

pH 7.5, 30°C

756049

2.3.1.31

0.051

-

25°C, pH 7.5

673497

2.3.1.31

0.273

-

E111G, 50 mM potassium phosphate buffer, pH 7.5, 2 mM L-homoserine, 25°C

687796

2.3.1.31

0.36

-

-

486788

2.3.1.31

3 entries

2.3.1.310

0.31

-

calculated, kinetic model: ternary complex mechanism, pH and temperature not specified in the publication

764661

2.3.1.37

0.00064

-

recombinant mutant G144A

486851

2.3.1.37

0.001

-

pH 7.5, 37°C, wild-type enzyme

736116

2.3.1.37

0.0011

-

mutant N150W, pH 7.5, 18°C

736491

2.3.1.37

0.0012

-

mutant N150H, pH 7.5, 18°C

736491

2.3.1.37

0.0012

-

mutant S254T, 30°C, pH 7.5

704690

2.3.1.37

0.0012

-

recombinant erythroid isoform and mutant G144S

486851

2.3.1.37

0.0013

-

wild-type, 30°C, pH 7.5

704690

2.3.1.37

0.0016

-

recombinant mutant Y121H

486855

2.3.1.37

0.0019

-

recombinant mutant G144T

486851

2.3.1.37

0.002

-

-

486835

2.3.1.37

0.002

-

erythroid-specific isoform

486848

2.3.1.37

0.002

-

recombinant erythroid isoform wild-type

486855, 486856, 486857

2.3.1.37

0.002

-

recombinant mutant G142C

486851

2.3.1.37

0.0021

-

mutant N150G, pH 7.5, 18°C

736491

2.3.1.37

0.0022

-

mutant N150F, pH 7.5, 18°C

736491

2.3.1.37

0.0022

-

recombinant erythroid isoform mutant R433K

486857

2.3.1.37

0.0023

-

wild-type enzyme, pH 7.5, 18°C

736491

2.3.1.37

0.0024

-

mutant enzyme H340A, at pH 7.5 and 25°C

758425

2.3.1.37

0.00242

-

wild type enzyme, at pH 7.5 and 25°C

758425

2.3.1.37

0.00255

-

mutant enzyme C398A, at pH 7.5 and 25°C

758425

2.3.1.37

0.00258

-

mutant enzyme H340A/C398A, at pH 7.5 and 25°C

758425

2.3.1.37

0.0029

-

wild-type, pH 7.5, 30°C

706627

2.3.1.37

0.0032

-

recombinant erythroid isoform mutant R433L

486857

2.3.1.37

0.0038

-

mutant N150A, pH 7.5, 18°C

736491

2.3.1.37

0.01

-

-

486810

2.3.1.37

0.011

-

-

486834

2.3.1.37

0.0124

-

mutant R85K, pH 7.5, 30°C

706627

2.3.1.37

0.013

-

-

486814

2.3.1.37

0.014

-

recombinant mutant Y121F

486855

2.3.1.37

0.0146

-

isoform HemA, pH and temperature not specified in the publication

757686

2.3.1.37

0.0146

-

wild type enzyme, at pH 7.2 and 37°C

758299

2.3.1.37

0.015

-

isoform HemT, pH and temperature not specified in the publication

757686

2.3.1.37

0.01513

-

mutant enzyme H15K, at pH 7.5 and 37°C

756270

2.3.1.37

0.0176

-

isoform HemA, pH and temperature not specified in the publication

757686

2.3.1.37

0.0184

-

isoform HemA, pH and temperature not specified in the publication

757686

2.3.1.37

0.02

-

-

486837

2.3.1.37

0.0203

-

mutant R85L, pH 7.5, 30°C

706627

2.3.1.37

0.0214

-

wild type enzyme, at pH 7.5 and 37°C

756270

2.3.1.37

0.02227

-

mutant enzyme H29R, at pH 7.5 and 37°C

756270

2.3.1.37

0.023

-

pH 7.5, 37°C, mutant K221V

736116

2.3.1.37

0.025

-

-

486812

2.3.1.37

0.0261

-

mutant C281P of isoform HemT, pH and temperature not specified in the publication

757686

2.3.1.37

0.027

-

recombinant erythroid isoform mutant R439K

486857

2.3.1.37

0.032

-

mutant S254A, 30°C, pH 7.5

704690

2.3.1.37

0.035

-

recombinant erythroid isoform mutant D279E

486856

2.3.1.37

0.0357

-

pH 7.4, 37°C, recombinant mutant DELTAAGTG

736819

2.3.1.37

0.0398

-

pH 7.4, 37°C, recombinant mutant DELTAAT

736819

2.3.1.37

0.0401

-

pH 7.4, 37°C, recombinant mutant DELTAG

736819

2.3.1.37

0.0407

-

pH 7.4, 37°C, recombinant wild-type enzyme

736819

2.3.1.37

0.055

-

-

486853

2.3.1.37

0.055

-

recombinant protein

486824

2.3.1.37

0.07

-

-

486812

2.3.1.37

0.0774

-

mutant enzyme T83S, at pH 7.2 and 37°C

758299

2.3.1.37

0.096

-

mutant R85L/T430V, pH 7.5, 30°C

706627

2.3.1.37

0.1

-

recombinant enzyme

486860

2.3.1.37

0.1302

-

mutant enzyme T83S/T363S, at pH 7.2 and 37°C

758299

2.3.1.37

0.1645

-

mutant enzyme T363S, at pH 7.2 and 37°C

758299

2.3.1.37

0.2

-

-

486843

2.3.1.37

0.45

-

pH 7.5, 30°C, mutant 2XALAS

663337

2.3.1.37

0.63

-

pH 7.5, 20°C, mutant 2XALAS

663337

2.3.1.37

1

-

wild type enzyme, at pH 7.5 and 37°C

756100

2.3.1.37

1.3

-

mutant enzyme DELTAmALAS2, at pH 7.5 and 37°C

756100

2.3.1.37

1.52

-

recombinant mutant dimer K149A/K313A

486852

2.3.1.37

1.82

-

-

486852

2.3.1.37

2.3

-

pH 7.5, 30°C, wild-type

663337

2.3.1.37

5

-

-

486833

2.3.1.37

10

-

-

486810, 486812

2.3.1.37

11

-

pH 7.5, 20°C, wild-type

663337

2.3.1.37

36.3

-

pH 7.4, 37°C, recombinant mutant F557X

736819

2.3.1.37

49.55

-

pH 7.5

661787

2.3.1.37

52.4

-

pH 7.4, 37°C, recombinant mutant Q548X

736819

2.3.1.46

0.043

-

pH 7.5, 25°C, recombinant mutant E246D

671625

2.3.1.46

0.05

-

pH 7.5, 25°C, recombinant mutant Y238F/E246A

671625

2.3.1.46

0.094

-

pH 7.2, 25°C, recombinant mutant K47R

672232

2.3.1.46

0.094

-

pH 7.5, 25°C, recombinant mutant E246A

671625

2.3.1.46

0.13

-

pH 7.2, 25°C, recombinant mutant K46R

672232

2.3.1.46

0.13

-

pH 7.2, 25°C, recombinant mutant K46R/K47R

672232

2.3.1.46

0.13

-

pH 7.2, 25°C, recombinant wild-type enzyme

672232

2.3.1.46

0.14

-

pH 7.2, 25°C, recombinant mutant C90S

672232

2.3.1.46

0.14

-

pH 7.2, 25°C, recombinant mutant K46A

672232

2.3.1.46

0.15

-

pH 7.5, 25°C, recombinant mutant E237A

671625

2.3.1.46

0.16

-

pH 7.2, 25°C, recombinant mutant K47A

672232

2.3.1.46

0.17

-

recombinant protein

487046

2.3.1.46

0.2

-

pH 7.5, 25°C, recombinant mutant R193A/E246A

671625

2.3.1.46

0.23

-

pH 7.5, 25°C, recombinant mutant R249A

671625

2.3.1.46

0.24

-

pH 7.5, 25°C, recombinant mutant E237D

671625

2.3.1.46

0.28

-

pH 7.5, 25°C, recombinant wild-type enzyme

671625

2.3.1.46

0.31

-

pH 7.5, 25°C, recombinant mutant R249K

671625

2.3.1.46

0.35

-

pH 7.5, 25°C, recombinant mutant Y238F

671625

2.3.1.46

0.36

-

recombinant His-tagged mutant I229Y, pH and temperature not specified in the publication

735854

2.3.1.46

0.37

-

recombinant His-tagged wild-type enzyme, pH and temperature not specified in the publication

735854

2.3.1.46

0.38

-

recombinant His-tagged mutant I124L, pH and temperature not specified in the publication

735854

2.3.1.46

0.4

-

pH 7.5, 25°C, recombinant mutant R193K

671625

2.3.1.46

0.43

-

pH 7.5, 25°C, recombinant mutant R193A

671625

2.3.1.46

1.78

-

pH 7.5, 25°C, recombinant mutant K46L

671625

2.3.1.46

2.9

-

pH 7.5, 25°C, recombinant mutant K45L

671625

2.3.1.61

0.06

-

-

487335

2.3.1.61

0.1

-

-

487348

2.3.1.37

71 entries

2.3.1.46

25 entries

2.3.1.61

2 entries

2.3.1.85

0.0021

-

didomain construct, pH not specified in the publication, 25°C

755686

2.8.3.13

0.15

-

pH 7.8, 30°C, cosubstrate glutarate

643834

2.8.3.13

0.22

-

pH 8.5, 30°C, cosubstrate 3-hydroxy-3-methylglutarate

643832

2.8.3.13

0.25

-

pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate

643833

2.8.3.13

0.26

-

pH 7.8, 30°C, cosubstrate adipate

643834

2.8.3.13

0.28

-

pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate

643834

2.8.3.13

0.75

-

pH 7.8, 30°C, cosubstrate malonate

643834

2.8.3.13

0.83

-

pH 7.8, 30°C, cosubstrate methylmalonate

643834

2.8.3.18

0.0221

-

-

692865

2.8.3.18

0.0221

-

pH 8.0, 25°C

692865

2.8.3.13

7 entries

2.8.3.18

2 entries

2.8.3.20

0.08

-

55°C, pH and temperature not specified in the publication

674298

2.8.3.22

0.5

-

55°C, pH not specified in the publication, recombinant enzyme

725238

2.8.3.26

2.8

-

37°C, pH 7.8

747846

2.8.3.27

0.068

-

at pH 8.0 and 25°C

765332

2.8.3.27

0.068

-

with propanoate as cosubstrate, at pH 7.8 and 25°C

765011

2.8.3.27

0.13

-

with acetate as cosubstrate, at pH 8.0 and 25°C

765011

2.8.3.5

0.156

-

cosusbstrate: acetoacetate

645973

2.8.3.5

0.28

-

pH 8.1, 25°C

645978

2.8.3.5

1.7

-

C28S mutant

672216

2.8.3.5

1.7

-

pH 8.1, 21-22°C, mutant C28S

672216

2.8.3.5

4.2

-

cosusbstrate: acetoacetate, pH 8.1

645967

2.8.3.5

6.5

-

pH 8.1, 21-22°C, wild-type enzyme

672216

2.8.3.5

6.5

-

wild-type SCOT

672216

2.8.3.5

8

-

C28A mutant

672216

2.8.3.5

8

-

pH 8.1, 21-22°C, mutant C196S

672216

2.8.3.27

3 entries

2.8.3.5

9 entries

2.8.3.6

0.2

-

pH 8, 25°C

646002

3.1.2.2

0.048

-

-

646180

3.1.2.20

0.014

-

-

679724

3.1.2.20

0.02

-

pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay

690932

3.1.2.20

0.048

-

-

646180

3.1.2.20

3 entries

3.1.2.3

13.3

-

-

665676

5.4.99.2

0.025

-

-

3505, 3516, 3517

5.4.99.2

0.0345

-

-

3502

5.4.99.2

0.062

-

-

3502

5.4.99.2

0.083

-

25°C, mutant H244A

650005

5.4.99.2

0.085

-

25°C, mutant H244Q

650005

5.4.99.2

0.096

-

25°C, wild-type

650005

5.4.99.2

0.3474

-

in 100 mM potassium phosphate buffer (pH 7.5), at 37°C

701956

5.4.99.2

7 entries

6.2.1.4

0.086

-

pH 8.0, 30°C

651897

6.2.1.5

0.0221

-

pH 8.0, 25°C

692865

6.2.1.5

0.024

-

-

808

6.2.1.5

0.041

-

pH 8.0, 30°C

651897

6.2.1.5

3 entries

6.4.1.3

1.01

-

pH 7.2, 30°C

649502