Ligand succinyl-CoA

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Basic Ligand Information

Molecular Structure
Picture of succinyl-CoA (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C25H40N7O19P3S
succinyl-CoA
VNOYUJKHFWYWIR-ITIYDSSPSA-N
Synonyms:
3-carboxypropyl-CoA, succinoyl-CoA, succinylCoA, succinyl CoA, succinyl coenzyme A
Pathway Source
Pathways
MetaCyc
(S)-lactate fermentation to propanoate, acetate and hydrogen, 2-amino-3-hydroxycyclopent-2-enone biosynthesis, 2-oxoglutarate decarboxylation to succinyl-CoA, 3-hydroxypropanoate cycle, 3-hydroxypropanoate/4-hydroxybutanate cycle more


Show all pahtways known for Show all BRENDA pathways known for succinyl-CoA

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (38 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
succinyl-CoA + L-homoserine = CoA + O-succinyl-L-homoserine
show the reaction diagram
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succinyl-CoA + L-homoserine = CoA + O-succinyl-L-homoserine
show the reaction diagram
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succinyl-CoA + [AcsA]-L-Lys = CoA + [AcsA]-N6-succinyl-L-Lys
show the reaction diagram
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succinyl-CoA + 3-hydroxy-3-methylglutarate = succinate + 3-hydroxy-3-methylglutaryl-CoA
show the reaction diagram
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succinyl-CoA + (R)-2-benzylsuccinate = succinate + (R)-2-benzylsuccinyl-CoA
show the reaction diagram
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succinyl-CoA + acetate = acetyl-CoA + succinate
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succinyl-CoA + oxalate = succinate + oxalyl-CoA
show the reaction diagram
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succinyl-CoA + (R)-citramalate = succinate + (R)-citramalyl-CoA
show the reaction diagram
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succinyl-CoA + (S)-malate = succinate + (S)-malyl-CoA
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mesaconate + succinyl-CoA = 2-methylfumaryl-CoA + succinate
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succinyl-CoA + H2O = ?
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Succinyl-CoA = ?
show the reaction diagram

In Vivo Product in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH
show the reaction diagram
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2-oxoglutarate + CoA + NADP+ = succinyl-CoA + CO2 + NADPH
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2-oxoglutarate + CoA + oxidized ferredoxin = succinyl-CoA + CO2 + reduced ferredoxin + H+
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CoA + 3-oxoadipyl-CoA = succinyl-CoA + acetyl-CoA
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propionyl-CoA + succinate = propanoate + succinoyl-CoA
show the reaction diagram
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succinate + (S)-(+)-citramalyl-CoA = succinyl-CoA + citramalate
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succinate + acetyl-CoA = acetate + succinyl-CoA
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ATP + succinate + CoA = ADP + phosphate + succinyl-CoA
show the reaction diagram
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ATP + propionyl-CoA + HCO3- + H+ = ADP + succinyl-CoA + phosphate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (122 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
succinyl-CoA + NADPH + H+ = succinate-semialdehyde + coenzyme A + NADP+
show the reaction diagram
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succinyl-CoA + biochanin A-beta-D-glucoside = coenzyme A + biochanin A 7-O-(6-O-succinyl-beta-D-glucoside)
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succinyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + N-succinyl-alpha-D-glucosamine 1-phosphate
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succinyl-CoA + shisonin = CoA + succinylshisonin
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succinyl-CoA + L-homoserine = CoA + O-succinyl-L-homoserine
show the reaction diagram
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succinyl-CoA + an [acyl-carrier protein] = CoA + succinyl-[acyl carrier protein]
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succinyl-CoA + 5-aminosalicylate = CoA + N-succinyl-5-aminosalicylate
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succinyl-CoA + an [acyl-carrier protein] = CoA + succinyl-[acyl-carrier protein]
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succinyl-CoA + [AcsA]-L-Lys = CoA + [AcsA]-N6-succinyl-L-Lys
show the reaction diagram
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succinyl-CoA + propanoate = ?
show the reaction diagram
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succinyl-CoA + oxalate = succinate + oxalyl-CoA
show the reaction diagram
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succinyl-CoA + oxalate = succinate + oxalyl-CoA
show the reaction diagram
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acetate + succinyl-CoA = succinate + acetyl-CoA
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succinyl-CoA = succinate + CoA
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succinyl-CoA + H2O = CoA + succinate
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succinyl-CoA + H2O = CoA + succinate
show the reaction diagram
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Succinyl-CoA = ?
show the reaction diagram
ADP + phosphate + succinyl-CoA = ATP + succinate + CoA
show the reaction diagram
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ATP + succinyl-CoA + HCO3- = ADP + phosphate + ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (46 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-oxoglutarate + CoA + NADP+ = succinyl-CoA + CO2 + NADPH
show the reaction diagram
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succinate semialdehyde + coenzyme A + NADP+ = succinyl-CoA + NADPH + H+
show the reaction diagram
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succinate-semialdehyde + coenzyme A + NADP+ = succinyl-CoA + NADPH + H+
show the reaction diagram
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succinate + acetyl-CoA = acetate + succinyl-CoA
show the reaction diagram
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(R)-2-methylmalonyl-CoA = succinyl-CoA
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methylmalonyl-CoA = succinyl-CoA
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ATP + succinate + CoA = ADP + phosphate + succinyl-CoA
show the reaction diagram
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ATP + succinate + CoA = ADP + phosphate + succinyl-CoA
show the reaction diagram
853,
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ATP + succinate + CoA = ADP + phosphate + succinyl-CoA
show the reaction diagram
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ATP + propionyl-CoA + HCO3- + H+ = ADP + succinyl-CoA + phosphate
show the reaction diagram
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Enzyme Cofactor/Cosubstrate (7 results)

Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation
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activates
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Inhibitor in Enzyme-catalyzed Reactions (28 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
about 60% residual activity at 2.5 mM
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partial proteolysis of CPT I slightly diminishes the inhibitory effect
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non-specific isoform ALAS-N in absence of ATP
inhibition of MCT2 at 0.02 mM and inhibition of both isozymes at 0.1 mM
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0.1 mM, 96% inhibtion
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mixed-type inhibition
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competitive inhibition
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0.1 mM, 22% inhibition
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product inhibitor
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at 1 mM 53% inhibition of activity (concentrations of substrates 1 mM)
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3D Structure of Enzyme-Ligand-Complex (PDB) (21 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (80 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.22
-
pH 7.5, 25°C
0.9
-
pH 7.5, 30°C
13.4
-
didomain construct, pH not specified in the publication, 25°C
13
-
55°C, pH and temperature not specified in the publication
11.4
-
55°C, pH not specified in the publication, recombinant enzyme
12.2
-
37°C, pH 7.8
37.3
-
pH 8.1
190
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pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
201
-
pH 8.0, 25°C

KM Value (148 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
3.2
-
pH 7.0, 30°C
0.25
-
pH and temperature not specified in the publication
0.04
-
-
0.101
-
-
1.1
-
pH 7.5, 30°C
0.0021
-
didomain construct, pH not specified in the publication, 25°C
0.08
-
55°C, pH and temperature not specified in the publication
0.5
-
55°C, pH not specified in the publication, recombinant enzyme
2.8
-
37°C, pH 7.8
0.2
-
pH 8, 25°C
0.048
-
-
13.3
-
-
0.086
-
pH 8.0, 30°C
1.01
-
pH 7.2, 30°C

Ki Value (4 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.9
-
pH 8.1
1.5
-
pH 6.0, 30°C

References & Links

Links to other databases for succinyl-CoA

ChEBI
PubChem
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PubChem