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Ligand phosphatidylinositol 3,5-bisphosphate

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.3.64

phosphatidylinositol 3,5-bisphosphate + H2O = phosphatidylinositol 5-phosphate + phosphate

646451

-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.3.78

phosphatidylinositol 3,4,5-trisphosphate + H2O = phosphatidylinositol 3,5-bisphosphate + phosphate

0

-

Substrate in Enzyme-catalyzed Reactions (4 results)

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Show Substrate (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.3.36

D-myo-phosphatidylinositol 3,5-bisphosphate = D-myo-phosphatidylinositol 3-phosphate

678074

-

3.1.3.36

phosphatidylinositol 3,5-bisphosphate + H2O = phosphatidylinositol 3-phosphate + phosphate

652022

-

3.1.3.36

2 entries

3.1.3.64

phosphatidylinositol 3,5-bisphosphate + H2O = phosphatidylinositol 5-phosphate + phosphate

682009, 680079, 646451

-

3.6.1.52

phosphatidylinositol 3,5-bisphosphate + H2O = ?

757172

-

Product in Enzyme-catalyzed Reactions (1 result)

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Show Product (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.3.78

phosphatidylinositol 3,4,5-trisphosphate + H2O = phosphatidylinositol 3,5-bisphosphate + phosphate

0

-

Inhibitor in Enzyme-catalyzed Reactions (4 results)

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Show Inhibitors (4 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

3.1.4.12

potent selective acid sphingomyelinase inhibitor

703199

-

3.1.4.12

-

714689

-

3.1.4.12

potent inhibitor

702696

-

3.1.4.12

3 entries

3.1.4.41

-

714926

-

Enzyme Kinetic Parameters

IC₅₀ Value (1 result)

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Show IC50 Value (1 entry)

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

COMMENTARY

LITERATURE

3.1.4.12

0.00093

-

in 100 mM NaOAc, pH 5.2, at 37°C

703199

References & Links

Literature References (10)

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Show Reference (10 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

646451

12646134

Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases

2003

Schaletzky, J.; Dove, S.K.; Short, B.; Lorenzo, O.; Clague, M.J.; Barr, F.A.

Curr. Biol.

13

504-509

652022

10806194

Cloning and characterization of a 72-kDa inositol-polyphosphate 5-phosphatase localized to the Golgi network

2000

Kong, A.M.; Speed, C.J.; O'Malley, C.J.; Layton, M.J.; Meehan, T.; Loveland, K.L.; Cheema, S.; Ooms, L.M.; Mitchell, C.A.

J. Biol. Chem.

275

24052-24064

678074

17672824

The control of phosphatidylinositol 3,4-bisphosphate concentrations by activation of the Src homology 2 domain containing inositol polyphosphate 5-phosphatase 2, SHIP2

2007

Batty, I.H.; van der Kaay, J.; Gray, A.; Telfer, J.F.; Dixon, M.J.; Downes, C.P.

Biochem. J.

407

255-266

680079

17008356

A novel PtdIns3P and PtdIns(3,5)P2 phosphatase with an inactivating variant in centronuclear myopathy

2006

Tosch, V.; Rohde, H.M.; Tronchere, H.; Zanoteli, E.; Monroy, N.; Kretz, C.; Dondaine, N.; Payrastre, B.; Mandel, J.L.; Laporte, J.

Hum. Mol. Genet.

15

3098-3106

682009

17917119

Myotubularin-related (MTMR) phospholipid phosphatase proteins in the peripheral nervous system

2007

Bolis, A.; Zordan, P.; Coviello, S.; Bolino, A.

Mol. Neurobiol.

35

308-316

702696

20005726

Development of carbohydrate-derived inhibitors of acid sphingomyelinase

2010

Roth, A.G.; Redmer, S.; Arenz, C.

Bioorg. Med. Chem.

18

939-944

703199

19688786

Potent inhibition of acid sphingomyelinase by phosphoinositide analogues

2009

Roth, A.G.; Redmer, S.; Arenz, C.

ChemBioChem

10

2367-2374

714689

20501999

Small molecule inhibitors of acid sphingomyelinase

2010

Arenz, C.

Cell. Physiol. Biochem.

26

1-8

714926

20350542

Entamoeba histolytica: soluble and membrane-associated neutral sphingomyelinase-C and other unidentified esterase activity

2010

Vargas-Villarreal, J.; Palacios-Corona, R.; Hernandez-Luna, C.; Mata-Cardenas, B.D.; Torres de la Cruz, V.M.; Cortes-Gutierrez, E.I.; Gonzalez-Salazar, F.; Garza-Gonzalez, J.N.; Escobedo-Guajardo, B.L.; Said-Fernandez, S.

Exp. Parasitol.

125

394-399

757172

26828065

A novel inositol pyrophosphate phosphatase in Saccharomyces cerevisiae Siw14 protein selectively cleaves the beta-phosphate from 5-diphosphoinositol pentakisphosphate (5PP-IP5)

2016

Steidle, E.A.; Chong, L.S.; Wu, M.; Crooke, E.; Fiedler, D.; Resnick, A.C.; Rolfes, R.J.

J. Biol. Chem.

291

6772-6783

Links to other databases for phosphatidylinositol 3,5-bisphosphate

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Show Links (1 entry)