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Ligand juvenile hormone III

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Natural Substrate (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.1.59

juvenile hormone III + H2O = ?

715184, 651500, 715173

-

3.1.1.59

juvenile hormone III + H2O = juvenile hormone III acid + methanol

715819

-

3.1.1.59

2 entries

3.3.2.9

juvenile hormone III + H2O = ?

731916

-

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

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Show Natural Product (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.14.127

methyl (2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2 = juvenile hormone III + [oxidized NADPH-hemoprotein reductase] + H2O

0

-

2.1.1.325

S-adenosyl-L-methionine + juvenile hormone III acid = S-adenosyl-L-homocysteine + juvenile hormone III

0

-

Substrate in Enzyme-catalyzed Reactions (4 results)

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Show Substrate (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.1.59

juvenile hormone III + H2O = ?

715173, 715184, 651504, 651512, 651500, 649498

-

3.1.1.59

juvenile hormone III + H2O = juvenile hormone III acid + methanol

651397, 651510, 715819, 23477, 23479, 23481, 23474, 750396, 651512, 649497, 649644, 680156, 707525

-

3.1.1.59

2 entries

3.3.2.10

juvenile hormone III + H2O = ?

208933

-

3.3.2.9

juvenile hormone III + H2O = ?

208935, 715183, 731225, 731916

-

Product in Enzyme-catalyzed Reactions (2 results)

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Show Product (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.14.127

methyl (2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2 = juvenile hormone III + [oxidized NADPH-hemoprotein reductase] + H2O

0

-

2.1.1.325

S-adenosyl-L-methionine + juvenile hormone III acid = S-adenosyl-L-homocysteine + juvenile hormone III

0

-

Activator in Enzyme-catalyzed Reactions (2 results)

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Show Activating Compound (2 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.14.16.2

0.0001 or 0.0002 mg juvenile hormone-III application leads to a substantial rise in tyrosine hydroxylase activity

695907

-

3.1.4.11

-

752037

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (15 results)

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Show Turnover Number (15 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

3.1.1.59

0.013

0.018

pH 7.4, 22°C, recombinant BmCCE-5

715173

3.1.1.59

0.164

-

pH and temperature not specified in the publication

715184

3.1.1.59

0.323

-

-

23477

3.1.1.59

0.7

-

wild-type, at 30°C in 50 mM sodium phosphate buffer, pH 7.4, containing 1 mg/mL of bovine serum albumin

707525

3.1.1.59

0.8

-

10S isomer of juvenile hormone III

680156

3.1.1.59

0.9

-

pH 8, major enzyme form with pI 5.6

649498

3.1.1.59

1

-

pH 7.4, 22°C, recombinant BmJHE

715173

3.1.1.59

1

-

racemic juvenile hormone III

680156

3.1.1.59

1.1

-

10R isomer of juvenile hormone III

680156

3.1.1.59

1.9

-

pH 8, minor enzyme form with pI 5.5

649498

3.1.1.59

4

-

mutant F259I, at 30°C in 50 mM sodium phosphate buffer, pH 7.4, containing 1 mg/mL of bovine serum albumin

707525

3.1.1.59

4.5

-

mutant T314V, at 30°C in 50 mM sodium phosphate buffer, pH 7.4, containing 1 mg/mL of bovine serum albumin

707525

3.3.2.9

0.002

-

in 100 mM sodium phosphate, pH 8.0, at 30°C

731916

3.3.2.9

0.03

-

at pH 8.0 and 30°C

731225

3.3.2.9

0.08

-

-

208935

3.1.1.59

12 entries

3.3.2.9

3 entries

K_M Value (21 results)

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Show KM Value (21 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.1.1.59

0.00003

-

wild-type, at 30°C in 50 mM sodium phosphate buffer, pH 7.4, containing 1 mg/mL of bovine serum albumin

707525

3.1.1.59

0.000086

-

mutant T314V, at 30°C in 50 mM sodium phosphate buffer, pH 7.4, containing 1 mg/mL of bovine serum albumin

707525

3.1.1.59

0.000089

-

-

651500

3.1.1.59

0.000091

-

pH not specified in the publication, 30°C

750396

3.1.1.59

0.000101

-

mutant F259I, at 30°C in 50 mM sodium phosphate buffer, pH 7.4, containing 1 mg/mL of bovine serum albumin

707525

3.1.1.59

0.00025

-

-

23479

3.1.1.59

0.000315

-

recombinant JHE

651512

3.1.1.59

0.00036

-

racemic, (10R,11S)-enantiomer of juvenile hormone II

23474

3.1.1.59

0.000367

-

pH not specified in the publication, 30°C

750396

3.1.1.59

0.000402

-

-

23481

3.1.1.59

0.000657

-

pH and temperature not specified in the publication

715184

3.1.1.59

0.0014

-

pH 8, major enzyme form with pI 5.6

649498

3.1.1.59

0.0022

-

pH 8, minor enzyme form with pI 5.5

649498

3.1.1.59

0.0025

-

pH 7.4, 22°C, recombinant BmCCE-5

715173

3.1.1.59

0.0028

-

pH 7.4, 22°C, recombinant BmJHE

715173

3.1.1.59

1.3

-

10R isomer of juvenile hormone III

680156

3.1.1.59

1.5

-

racemic juvenile hormone III

680156

3.1.1.59

2.4

-

10S isomer of juvenile hormone III

680156

3.3.2.9

0.00028

-

-

208935

3.3.2.9

0.0032

-

in 100 mM sodium phosphate, pH 8.0, at 30°C

731916

3.3.2.9

0.0138

-

at pH 8.0 and 30°C

731225

3.1.1.59

18 entries

3.3.2.9

3 entries

References & Links

Literature References (25)

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Show Reference (25 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

23474

-

Characterization of hemolymph juvenile hormone esterase from Lymantria dispar

1991

Valaitis, A.P.

Insect Biochem.

21

583-595

23477

-

3-Octylthio-1,1,1-trifluoro-2-propanone, a high affinity and slow binding inhibitor of juvenile hormone esterase from Trichoplusia ni (Huebner)

1985

Abdel-Aal, Y.A.I.; Hammock, B.D.

Insect Biochem.

15

111-122

23479

-

Inhibition and substrate specificity of the hemolymph juvenile hormone esterase of the cabbage looper, Trichoplusia ni (Huebner)

1983

Sparks, T.C.; Rose, R.L.

Insect Biochem.

13

633-640

23481

-

Purification and kinetics of juvenile hormone esterase from the cabbage looper, Trichoplusia ni (Hubner)

1983

Yuhas, D.A.; Roe, R.M.; Sparks, T.C.; Hammond, A.M.

Insect Biochem.

13

129-136

208933

10860549

Cress and potato soluble epoxide hydrolases: purification, biochemical characterization, and comparison to mammalian enzymes

2000

Morisseau, C.; Beetham, J.K.; Pinot, F.; Debernard, S.; Newman, J.W.; Hammock, B.D.

Arch. Biochem. Biophys.

378

321-332

208935

8396141

Juvenile hormone epoxide hydrolase. Photoaffinity labeling, purification, and characterization from tobacco hornworm eggs

1993

Touhara, K.; Prestwich, G.D.

J. Biol. Chem.

268

19604-19609

649497

-

Characterization of the esterase isoenzymes of Ips typographus (Coleoptera, Scolytidae)

1997

Stauffer, C.; Shiotsuki, T.; Chan, W.; Hammock, B.D.

Arch. Insect Biochem. Physiol.

34

203-221

649498

9177132

Purification and characterization of juvenile hormone esterase from hemolymph of the Colorado potato beetle

1997

Vermunt, A.M.W.; Vermeesch, A.M.G.; de Kort, C.A.D.

Arch. Insect Biochem. Physiol.

35

261-277

649644

9126671

Biochemical characterization of juvenile hormone esterases from lines selected for high or low enzyme activity in Gryllus assimilis

1996

Zera, A.J.; Zeisset, M.

Biochem. Genet.

34

421-435

651397

10603275

Effect of octopamine on the activity of juvenile-hormone esterase in the silkworm Bombyx mori and the red flour beetle Tribolium freemani

1999

Hirashima, A.; Suetsugu, E.; Hirokado, S.; Kuwano, E.; Taniguchi, E.; Eto, M.

Gen. Comp. Endocrinol.

116

373-381

651500

9718682

Purification and kinetic characterisation of juvenile hormone esterase from Drosophila melanogaster

1998

Campbell, P.M.; Oakeshott, J.G.; Healy, M.J.

Insect Biochem. Mol. Biol.

28

501-515

651504

10876123

The interactions between juvenile hormone (JH), lipophorin, vitellogenin, and JH esterases in two cockroach species

2000

Engelmann, F.; Mala, J.

Insect Biochem. Mol. Biol.

30

793-803

651510

14599498

Juvenile hormone (JH) esterase: why are you so JH specific?

2003

Kamita, S.G.; Hinton, A.C.; Wheelock, C.E.; Wogulis, M.D.; Wilson, D.K.; Wolf, N.M.; Stok, J.E.; Hock, B.; Hammock, B.D.

Insect Biochem. Mol. Biol.

33

1261-1273

651512

12706627

Juvenile hormone esterase (JHE) from Tenebrio molitor: full-length cDNA sequence, in vitro expression, and characterization of the recombinant protein

2003

Hinton, A.C.; Hammock, B.D.

Insect Biochem. Mol. Biol.

33

477-487

680156

17517331

Only one esterase of Drosophila melanogaster is likely to degrade juvenile hormone in vivo

2007

Crone, E.J.; Sutherland, T.D.; Campbell, P.M.; Coppin, C.W.; Russell, R.J.; Oakeshott, J.G.

Insect Biochem. Mol. Biol.

37

540-549

695907

19802901

20-hydroxyecdysone and juvenile hormone influence tyrosine hydroxylase activity in Drosophila females under normal and heat stress conditions

2009

Gruntenko, N.E.; Karpova, E.K.; Chentsova, N.A.; Adonyeva, N.V.; Rauschenbach, I.Y.

Arch. Insect Biochem. Physiol.

72

263-272

707525

20307057

Function of phenylalanine 259 and threonine 314 within the substrate binding pocket of the juvenile hormone esterase of Manduca sexta

2010

Kamita, S.G.; Wogulis, M.D.; Law, C.S.; Morisseau, C.; Tanaka, H.; Huang, H.; Wilson, D.K.; Hammock, B.D.

Biochemistry

49

3733-3742

715173

20060470

Molecular characterization and functional analysis of novel carboxyl/cholinesterases with GQSAG motif in the silkworm Bombyx mori

2010

Tsubota, T.; Shimomura, M.; Ogura, T.; Seino, A.; Nakakura, T.; Mita, K.; Shinoda, T.; Shiotsuki, T.

Insect Biochem. Mol. Biol.

40

100-112

715183

20337748

Molecular characterization and enzymatic analysis of juvenile hormone epoxide hydrolase genes in the red flour beetle Tribolium castaneum

2010

Tsubota, T.; Nakakura, T.; Shiotsuki, T.

Insect Mol. Biol.

19

399-408

715184

20522120

Molecular characterization of a gene encoding juvenile hormone esterase in the red flour beetle, Tribolium castaneum

2010

Tsubota, T.; Minakuchi, C.; Nakakura, T.; Shinoda, T.; Shiotsuki, T.

Insect Mol. Biol.

19

527-535

715819

20230830

The juvenile hormone (JH) epoxide hydrolase gene in the honey bee (Apis mellifera) genome encodes a protein which has negligible participation in JH degradation

2010

Mackert, A.; Hartfelder, K.; Bitondi, M.M.; Simoes, Z.L.

J. Insect Physiol.

56

1139-1146

731225

23704009

Characterization of Hovi-mEH1, a microsomal epoxide hydrolase from the glassy-winged sharpshooter Homalodisca vitripennis

2013

Kamita, S.G.; Oshita, G.H.; Wang, P.; Morisseau, C.; Hammock, B.D.; Nandety, R.S.; Falk, B.W.

Arch. Insect Biochem. Physiol.

83

171-179

731916

23276675

Cloning and characterization of a microsomal epoxide hydrolase from Heliothis virescens

2013

Kamita, S.G.; Yamamoto, K.; Dadala, M.M.; Pha, K.; Morisseau, C.; Escaich, A.; Hammock, B.D.

Insect Biochem. Mol. Biol.

43

219-228

750396

-

Characterization and kinetics of juvenile hormone esterase from Spodoptera littoralis (Boisd.) and S. frugiperda (J. E. Smith) (Lepidoptera Noctuidae)

2015

El-Sheikh, E.

Egypt. J. Biol. Pest Control

25

625-630

752037

25825754

Juvenile hormone-activated phospholipase C pathway enhances transcriptional activation by the methoprene-tolerant protein

2015

Liu, P.; Peng, H.; Zhu, J.

Proc. Natl. Acad. Sci. USA

112

E1871-E1879

Links to other databases for juvenile hormone III

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Show Links (1 entry)

ChEBI

PubChem