Ligand Quinine

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Basic Ligand Information

Molecular Structure
Picture of Quinine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C20H24N2O2
Quinine
LOUPRKONTZGTKE-WZBLMQSHSA-N
Synonyms:
quinine[side 1], quinine[side 2]

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
quinine + [reduced NADPH-hemoprotein reductase] + O2 = 3-hydroxyquinine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram

Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
quinine + [reduced NADPH-hemoprotein reductase] + O2 = 3-hydroxyquinine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
quinine + H2O + O2 = ?
show the reaction diagram
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ATP + H2O + quinine[side 1] = ADP + phosphate + quinine[side 2]
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + H2O + quinine[side 1] = ADP + phosphate + quinine[side 2]
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (18 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.49 mM, complete loss of activity
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20% inhibition at 1 mM
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4.2 mM, 30% inhibition
-
maximum inhibition of etoposide 3'-demethylation of 52% at 0.1 mM
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slight
-
0.2 mM, 50% inhibition
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3 mM, 23% inhibition
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about 18% inhibition at 0.1 mM
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mixed type, 33% inhibition at 3.2 mM, 67% inhibition at 7.5 mM
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IC50 ketonase reaction 34.9 microM, pH 6.5, room temperatur, IC50 enolase reaction 156.3 microM, pH 6.2, room temperatur
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3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (8 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.252
-
-
0.007
-
-

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE

References & Links

Links to other databases for Quinine

ChEBI
PubChem
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PubChem