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Ligand 5-trifluoromethyluracil

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.2.2

2'-deoxyuridine + 5-trifluoromethyluracil = 5-trifluoromethyl-2'-deoxyuridine + uracil

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2.4.2.6

2'-deoxyuridine + 5-trifluorothymine = 5-trifluorothymidine + uracil

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Product in Enzyme-catalyzed Reactions (2 results)

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EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.2.2

5-trifluoromethyl-2'-deoxyuridine + phosphate = 5-trifluoromethyluracil + 2-deoxy-D-ribose 1-phosphate

0

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2.4.2.2

5-trifluorothymidine + phosphate = 5-trifluorothymine + 2-deoxy-alpha-D-ribose 1-phosphate

0

-

2.4.2.2

2 entries

Inhibitor in Enzyme-catalyzed Reactions (1 result)

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EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.3.1.2

-

349216

-

Enzyme Kinetic Parameters

References & Links

Literature References (3)

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BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

349216

1544906

Mechanism-based inactivation of dihydropyrimidine dehydrogenase by 5-ethynyluracil

1992

Porter, D.J.T.; Chestnut, W.G.; Merrill, B.M.; Spector, T.

J. Biol. Chem.

267

5236-5242

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A comparison between immobilized pyrimidine nucleoside phosphorylase from Bacillus subtilis and thymidine phosphorylase from Escherichia coli in the synthesis of 5-substituted pyrimidine 2'-deoxyribonucleosides

2013

Serra, I.; Bavaro, T.; Cecchini, D.; Daly, S.; Albertini, A.; Terreni, M.; Ubiali, D.

J. Mol. Catal. B

95

16-22

736846

25090115

Nucleoside 2'-deoxyribosyltransferase from psychrophilic bacterium Bacillus psychrosaccharolyticus - preparation of an immobilized biocatalyst for the enzymatic synthesis of therapeutic nucleosides

2014

Fresco-Taboada, A.; Serra, I.; Fernandez-Lucas, J.; Acebal, C.; Arroyo, M.; Terreni, M.; de la Mata, I.

Molecules

19

11231-11249

Links to other databases for 5-trifluoromethyluracil

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Show Links (1 entry)

ChEBI

PubChem

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