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Ligand boldenone

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.17

UDP-D-glucuronate + dehydrotestosterone = UDP + dehydrotestosterone 17-O-beta-D-glucuronoside

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Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.17.99.11

1-dehydrotestosterone + H2O + 2,6-dichlorophenolindophenol = ? + reduced 2,6-dichlorophenolindophenol

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1.3.1.3

1,4-androstadien-17beta-ol-3-one + NADPH + H+ = ?

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2.4.1.17

UDP-D-glucuronate + dehydrotestosterone = UDP + dehydrotestosterone 17-O-beta-D-glucuronoside

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Product in Enzyme-catalyzed Reactions (5 results)

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Show Product (5 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.3.99.4

4-androstene-17beta-ol-3-one + 2,6-dichlorophenol-indophenol = 1,4-androstadiene-17beta-ol-3-one + reduced 2,6-dichlorophenol-indophenol

0

-

1.3.99.4

testosterone + 2,6-dichlorophenol-indophenol = 17beta-hydroxyandrost-1,4-diene-3-one + reduced 2,6-dichlorophenol-indophenol

0

-

1.3.99.4

testosterone + acceptor = 17beta-hydroxyandrost-1,4-diene-3-one + reduced acceptor

0

-

1.3.99.4

3 entries

3.1.6.1

boldenone 17-sulfate + H2O = boldenone + sulfate

0

-

3.1.6.2

boldenone 17-sulfate + H2O = boldenone + sulfate

0

-

Inhibitor in Enzyme-catalyzed Reactions (3 results)

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Show Inhibitors (3 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.3.1.22

50% inhibition

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1.4.1.3

-

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3.1.1.8

-

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Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

1.3.1.3

0.035

-

pH 6.0, 37°C

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K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.3.1.3

0.0032

-

pH 6.0, 37°C

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K_i Value (1 result)

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Show KI Value (1 entry)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.3.1.22

0.146

-

-

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IC₅₀ Value (5 results)

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Show IC50 Value (5 entries)

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

COMMENTARY

LITERATURE

1.4.1.3

0.0494

-

pH 8.0, temperature not specified in the publication

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1.4.1.3

0.0915

-

presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication

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1.4.1.3

0.494

-

pH 8.0, temperature not specified in the publication

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1.4.1.3

0.814

-

presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication

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1.4.1.3

4 entries

3.1.1.8

0.0209

-

-

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References & Links

Literature References (6)

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Show Reference (6 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

390765

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Some characteristics of the microsomal steroid reductase (5alpha) of rat liver

1960

McGuire, J.S.; Hollis, V.W.; Tomkins, G.M.

J. Biol. Chem.

235

3112-3117

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18728994

Butyrylcholinesterase inhibitory activity of testosterone and some of its metabolites

2008

Al-Aboudi, A.; Odeh, H.; Khalid, A.; Naz, Q.; Choudhary, M.I.

J. Enzyme Inhib. Med. Chem.

24

553-558

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18467088

Inactivation by UDP-glucuronosyltransferase enzymes: the end of androgen signaling

2008

Chouinard, S.; Yueh, M.F.; Tukey, R.H.; Giton, F.; Fiet, J.; Pelletier, G.; Barbier, O.; Belanger, A.

J. Steroid Biochem. Mol. Biol.

109

247-253

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21255593

Substrate specificity and inhibitor analyses of human steroid 5beta-reductase (AKR1D1)

2011

Chen, M.; Drury, J.E.; Penning, T.M.

Steroids

76

484-490

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27422263

Widening spectrum of cellular and subcellular expression of human GLUD1 and GLUD2 glutamate dehydrogenases suggests novel functions

2017

Spanaki, C.; Kotzamani, D.; Plaitakis, A.

Neurochem. Res.

42

92-107

759379

26872041

Integrated multi-omics analyses reveal the biochemical mechanisms and phylogenetic relevance of anaerobic androgen biodegradation in the environment

2016

Yang, F.; Chen, Y.; Tang, S.; Yu, C.; Wang, P.; Ismail, W.; Wang, C.; Ding, J.; Yang, C.; Yang, C.; Chiang, Y.

ISME J.

10

1967-1983

Links to other databases for boldenone

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Show Links (1 entry)

ChEBI

PubChem