Ligand L-2-amino-4-methoxy-4-oxobutanoic acid
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Basic Ligand Information
Molecular Structure

C5H9NO4
L-2-amino-4-methoxy-4-oxobutanoic acid
SBRYFUVVWOMLLP-VKHMYHEASA-N
L-aspartate beta-methyl ester, L-Asp beta-methyl ester
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (4 results)
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L-2-amino-4-methoxy-4-oxobutanoic acid + 2-oxoglutarate = 4-methoxy-2,4-dioxobutanoic acid + L-glutamate
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L-2-amino-4-methoxy-4-oxobutanoic acid + oxaloacetate = 4-methoxy-2,4-dioxobutanoic acid + L-aspartate
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ATP + L-aspartate beta-methyl ester = ?
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L-Asp beta-methyl ester + H2O = L-Asp + methanol
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3D Structure of Enzyme-Ligand-Complex (PDB) (6 results)
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Enzyme Kinetic Parameters
KM Value (3 results)
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4.1
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isozyme AAT2, 25°C
20.3
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isozyme AAT1, 25°C
4.9
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pH 8.0, 25°C, aspartokinase III
References & Links
Literature References (3)
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Effects of substrate structural analogues on the enzymatic activities of aspartate aminotransferase isoenzymes
2001
Martins, L.L.; Mourato, M.P.; de Varennes, A.
J. Enzyme Inhib.
16
251-257
Specificity of aspartokinase III from Escherichia coli and an examination of important catalytic residues
1996
Keng, Y.F.; Viola, R.E.
Arch. Biochem. Biophys.
335
73-81
The human asparaginase-like protein 1 hASRGL1 is an Ntn hydrolase with beta-aspartyl peptidase activity
2009
Cantor, J.R.; Stone, E.M.; Chantranupong, L.; Georgiou, G.
Biochemistry
48
11026-11031
Links to other databases for L-2-amino-4-methoxy-4-oxobutanoic acid