Ligand methylmalonate

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Basic Ligand Information

Molecular Structure
Picture of methylmalonate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H6O4
methylmalonate
ZIYVHBGGAOATLY-UHFFFAOYSA-N
Synonyms:
2-methylmalonate

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(S)-methylmalonyl-CoA + H2O = methylmalonate + CoA
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-methylmalonate + H+ = propionate + CO2
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
methylmalonyl-CoA + malonate = malonyl-CoA + methylmalonate
show the reaction diagram
-
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(S)-methylmalonyl-CoA + H2O = CoA + methylmalonate
show the reaction diagram
-
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
stimulates by chelating and stabilizing Mn3+
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Inhibitor in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive against L-serine, noncompetitive against NADP+
-
50% inhibition at 15 mM
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38% inhibition at 1 mM
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3D Structure of Enzyme-Ligand-Complex (PDB) (11 results)

Enzyme Kinetic Parameters

KM Value (5 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (4 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
3.02
-
enzyme from brain
15
-
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IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
4.6
-
IC50: 4.6 mM (enzyme from brain), 4.6 mM (enzyme from liver)

References & Links

Links to other databases for methylmalonate

ChEBI
PubChem
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PubChem