Ligand Isovaleraldehyde

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Basic Ligand Information

Molecular Structure
Picture of Isovaleraldehyde (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H10O
Isovaleraldehyde
BQUMGLWLUHHZEX-NQIIRXRSSA-N
Synonyms:
3-methyl-1-butanal, 3-methyl-butan-1-one, 3-Methylbutanal, 3-methylbutanaldehyde, 3-methylbutyraldehyde, iso-pentanal, isoamylaldehyde, isopentaldehyde, isopentanal, isovalerylaldehyde


Show all pahtways known for Show all BRENDA pathways known for Isovaleraldehyde

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
isovaleraldehyde + NADPH + H+ = isoamyl alcohol + NADP+
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (37 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
isovaleraldehyde + NADPH + H+ = isoamyl alcohol + NADP+
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3-methylbutanal + NADP+ = ? + NADPH + H+
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3-methylbutanal + NADPH = 3-methylbutanol + NADP+
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isovaleraldehyde + NAD+ + H2O = isovalerate + NADH + H+
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isopentanal + NADP+ + H2O = isopentanoate + NADPH + H+
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isovaleraldehyde + NAD+ + H2O = isovalerate + NADH + 2 H+
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isovaleraldehyde + NADP+ + H2O = isovalerate + NADPH + H+
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isovaleraldehyde + NAD+ + H2O = 3-methylbutanoate + NADH + 2 H+
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isovaleraldehyde + H2O + O2 = isovaleric acid + H2O2
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isovalerylaldehyde + H2O + oxidized benzyl viologen = isovalerate + H+ + reduced benzyl viologen
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3-methylbutanal + 1-hydroxypropan-2-one = (3R,4S)-3,4-dihydroxy-6-methylheptan-2-one
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isovaleraldehyde = (R)-5-hydroxy-2,7-dimethyloctan-4-one
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isovaleraldehyde = ?
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isovaleraldehyde = (R)-5-hydroxy-2,7-dimethyloctan-4-one
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D-ribulose 5-phosphate + isovaleraldehyde = ?
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Product in Enzyme-catalyzed Reactions (19 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3-methyl-1-butanol + ubiquinone = 3-methyl-1-butanal + ubiquinol
show the reaction diagram
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3-methyl-2-butenal + NADPH = 3-methylbutanal + NADP+
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isoamylamine + H2O + O2 = isoamylaldehyde + NH3 + H2O2
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Inhibitor in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
presence of NADPH, Ki: 7.14 mM, presence of NADH, Ki: 253 mM
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1 mM causes 57% inhibition at 30°C
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50% inhibition at 4 mM
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4 mM, 50% inhibition
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (21 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.65
-
1 mM
27.31
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with NAD+ as cofactor, in 50 mM potassium phosphate buffer (pH 8.0), at 37°C
0.074
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in 50 mM Tris-HCl (pH 7.5), at 25°C
272
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pH 8.4, 85°C, benzyl viologen as electron acceptor
272
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with benzyl viologen as cosubstrate, at 85°C

KM Value (30 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.33
-
1 mM
0.03
-
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1.66
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in 50 mM Tris-HCl (pH 7.5), at 25°C
0.028
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pH 8.4, 85°C, benzyl viologen as electron acceptor

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.1
-
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References & Links

Links to other databases for Isovaleraldehyde

ChEBI
PubChem
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PubChem