Ligand N10-formyltetrahydropteroylglutamate

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Basic Ligand Information

Molecular Structure
Picture of N10-formyltetrahydropteroylglutamate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C20H21N7O7
N10-formyltetrahydropteroylglutamate
UXFQDXABPXWSTK-ZDUSSCGKSA-N
Synonyms:
10-formyl-7,8-dihydrofolate, 10-formyl-dihydrofolate, 10-formyldihydrofolate, 10-formyldihydropteroylglutamate, Dihydro-10-carbonylfolic acid, N10-formyl-7,8-dihydrofolate, N10-formyltetrahydrofolic acid
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
10-formyl-dihydrofolate + NADPH + H+ = 10-formyl-tetrahydrofolate + NADP+
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
10-formyl-dihydrofolate + NADPH + H+ = 10-formyl-tetrahydrofolate + NADP+
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + formate + dihydrofolate = ADP + phosphate + 10-formyldihydrofolate
show the reaction diagram
-

Enzyme Cofactor/Cosubstrate (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
4.6
-
pH 7.5, temperature not specified in the publication
7.18
-
pH 7.5, temperature not specified in the publication

KM Value (2 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.003
-
pH 7.5, temperature not specified in the publication
0.245
-
pH 7.5, temperature not specified in the publication

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0075
-
-

References & Links

Links to other databases for N10-formyltetrahydropteroylglutamate

ChEBI
PubChem
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PubChem